Detection of Hepatitis A Virus in a Factor VIII Preparation by Antigen Capture/PCR

Vox Sanguinis ◽  
1994 ◽  
Vol 67 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Andrea Normann ◽  
Judith Graff ◽  
Bertram Flehmig
Keyword(s):  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Antigen Capture

Detection of Hepatitis A Virus in a Factor VIII Preparation by Antigen Capture/PCR

Vox Sanguinis ◽  
1994 ◽  
Vol 67 ◽  
pp. 57-61 ◽  
Author(s):  
Andrea Normann ◽  
Judith Graff ◽  
Bertram Flehmig
Keyword(s):  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Antigen Capture

“In vitro” and in Animal Model Studies on a Double Virus- Inactivated Factor VIII Concentrate

1995 ◽  
Vol 74 (03) ◽  
pp. 868-873 ◽  
Author(s):  
Silvana Arrighi ◽  
Roberta Rossi ◽  
Maria Giuseppina Borri ◽  
Vladimir Lesnikov ◽  
Marina Lesnikov ◽  
...  
Keyword(s):  
Heat Treatment ◽  
Animal Model ◽  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Virus Inactivation ◽  
Enveloped Viruses ◽  
Model Studies ◽  
Heat Treated

SummaryTo improve the safety of plasma derived factor VIII (FVIII) concentrate, we introduced a final super heat treatment (100° C for 30 min) as additional virus inactivation step applied to a lyophilized, highly purified FVIII concentrate (100 IU/mg of proteins) already virus inactivated using the solvent/detergent (SID) method during the manufacturing process.The efficiency of the super heat treatment was demonstrated in inactivating two non-lipid enveloped viruses (Hepatitis A virus and Poliovirus 1). The loss of FVIII procoagulant activity during the super heat treatment was of about 15%, estimated both by clotting and chromogenic assays. No substantial changes were observed in physical, biochemical and immunological characteristics of the heat treated FVIII concentrate in comparison with those of the FVIII before heat treatment.

Nachweis von Hepatitis-A-Virus-RNA in einem Faktor-VIII-Präparat mittels „antigen capture“/PCR

1993 ◽  
pp. 206-209
Author(s):  
A. Normann ◽  
J. Graff ◽  
A. Gerritzen ◽  
H.-H. Brackmann ◽  
J. Oldenburg ◽  
...  
Keyword(s):  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Antigen Capture ◽  
Virus Rna ◽  
Faktor Viii

Sequence Variability of Hepatitis A Virus and Factor VIII Associated Hepatitis A Infections in Hemophilia Patients in Europe: An Update

Vox Sanguinis ◽  
1994 ◽  
Vol 67 ◽  
pp. 39-46 ◽  
Author(s):  
Betty H. Robertson ◽  
Devorah Friedberg ◽  
Daniel Shouval ◽  
Andrea Normann ◽  
Judith Graff ◽  
...  
Keyword(s):  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Sequence Variability

Detection of hepatitis A virus RNA in commercially available factor VIII preparation

The Lancet ◽  
1992 ◽  
Vol 340 (8829) ◽  
pp. 1232-1233 ◽  
Author(s):  
A. Normann ◽  
J. Graff ◽  
A. Gerritzen ◽  
H.-H. Brackmann ◽  
B. Flehmig
Keyword(s):  
Factor Viii ◽  
Hepatitis A ◽  
Hepatitis A Virus ◽  
Virus Rna
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