Further Studies on Creatine Kinase Activity in Human Skeletal Muscle

Enzyme ◽  
1978 ◽  
Vol 23 (3) ◽  
pp. 182-186 ◽  
Author(s):  
G. Haralambie
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Human Skeletal Muscle ◽  
Kinase Activity ◽  
Creatine Kinase Activity

scholarly journals Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle

2012 ◽  
Vol 590 (21) ◽  
pp. 5475-5486 ◽  
Author(s):  
Christopher G. R. Perry ◽  
Daniel A. Kane ◽  
Eric A. F. Herbst ◽  
Kazutaka Mukai ◽  
Daniel S. Lark ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Human Skeletal Muscle ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Mitochondrial Creatine Kinase

Inhibition of the Electron Transport Chain and Creatine Kinase Activity by Ethylmalonic Acid in Human Skeletal Muscle

2006 ◽  
Vol 21 (1) ◽  
pp. 11-19 ◽  
Author(s):  
Alethea G. Barschak ◽  
Gustavo da C. Ferreira ◽  
Karina R. André ◽  
Patrícia F. Schuck ◽  
Carolina M. Viegas ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Electron Transport ◽  
Electron Transport Chain ◽  
Human Skeletal Muscle ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Ethylmalonic Acid ◽  
Transport Chain

Creatine kinase activity in human skeletal-muscle membranes

1986 ◽  
Vol 14 (1) ◽  
pp. 126-127 ◽  
Author(s):  
RUSSELL J. M. LANE ◽  
NICHOLAS J. WATMOUGH ◽  
SHASHI CHAMPANERIA ◽  
RONALD J. T. PENNINGTON
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Human Skeletal Muscle ◽  
Kinase Activity ◽  
Creatine Kinase Activity

Creatine kinase:aspartate aminotransferase activity ratio as an indicator of the source of an increased creatine kinase activity.

1988 ◽  
Vol 34 (12) ◽  
pp. 2506-2510 ◽  
Author(s):  
D R Dufour
Keyword(s):  
Myocardial Infarction ◽  
Skeletal Muscle ◽  
Acute Myocardial Infarction ◽  
Creatine Kinase ◽  
Retrospective Study ◽  
Kinase Activity ◽  
Activity Ratio ◽  
Creatine Kinase Activity ◽  
Aminotransferase Activity ◽  
Creatine Kinase Isoenzyme

Abstract Although measurements of creatine kinase isoenzyme 2 (CK-MB) are often used to diagnose acute myocardial infarction, their sensitivity and specificity are less than 100%. Because skeletal muscle contains more CK and less aspartate aminotransferase (AST) than cardiac muscle, the CK/AST ratio might provide a useful adjunct in evaluating the source of a supranormal value for CK. I established the following decision levels in a retrospective study of 342 patients: ratios less than 14 (if total CK was 300-1200 U/L), less than 20 (CK 1201-2000 U/L), or less than 25 (CK greater than 2000 U/L) suggested myocardial infarction, with a sensitivity of 95% and a specificity of 65%. In a validation study with 277 additional patients, liver disease and alcohol abuse caused erroneous results, leading to exclusion of 22% of these patients. In the remaining cases, sensitivity was 94%, specificity 90%. The CK/AST ratios changed little with time, suggesting that a single value would be adequate for evaluating patients with increased CK.

D-2-Hydroxyglutaric acid inhibits creatine kinase activity from cardiac and skeletal muscle of young rats

2003 ◽  
Vol 33 (10) ◽  
pp. 840-847 ◽  
Author(s):  
C. G. Da Silva ◽  
A. R. F. Bueno ◽  
P. F. Schuck ◽  
G. Leipnitz ◽  
C. A. J. Ribeiro ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Kinase Activity ◽  
Creatine Kinase Activity ◽  
Young Rats ◽  
Hydroxyglutaric Acid

Gender differences in muscle inflammation after eccentric exercise

2000 ◽  
Vol 89 (6) ◽  
pp. 2325-2332 ◽  
Author(s):  
N. Stupka ◽  
S. Lowther ◽  
K. Chorneyko ◽  
J. M. Bourgeois ◽  
C. Hogben ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Kinase Activity ◽  
Morphological Changes ◽  
Vastus Lateralis ◽  
Creatine Kinase Activity ◽  
Blue Staining ◽  
Positive Staining

Unaccustomed exercise is followed by delayed-onset muscle soreness and morphological changes in skeletal muscle. Animal studies have demonstrated that women have an attenuated response to muscle damage. We studied the effect of eccentric exercise in untrained male ( n = 8) and female ( n = 8) subjects using a unilateral exercise design [exercise (Ex) and control (Con) legs]. Plasma granulocyte counts [before (Pre) and 48 h after exercise (+48h)] and creatine kinase activity [Pre, 24 h after exercise (+24h), +48h, and 6 days after exercise (+6d)] were determined before (Pre) and after (+24h, +48h, +6d) exercise, with biopsies taken from the vastus lateralis of each leg at +48h for determination of muscle damage and/or inflammation. Plasma granulocyte counts increased for men and decreased for women at +48h ( P < 0.05), and creatine kinase activity increased for both genders at +48h and +6d ( P < 0.01). There were significantly greater areas of both focal ( P < 0.001) and extensive ( P < 0.01) damage in the Ex vs. Con leg for both genders, which was assessed by using toluidine blue staining. The number of leukocyte common antigen-positive cells/mm2 tissue increased with exercise ( P< 0.05), and men tended to show more in their Ex vs. Con leg compared with women ( P = 0.052). Men had a greater total (Ex and Con legs) number of bcl-2-positive cells/mm2 tissue vs. women ( P < 0.05). Atrophic fibers with homogeneous bcl-2-positive staining were seen only in men ( n = 3). We conclude that muscle damage is similar between genders, yet the inflammatory response is attenuated in women vs. men. Finally, exercise may stimulate the expression of proteins involved in apoptosis in skeletal muscle.

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