Effect of Natural Progesterone Treatment during Pregnancy on Fetal Testosterone and Sexual Behavior of the Male Offspring in the Mouse

1987 ◽  
Vol 10 (5) ◽  
pp. 385-392 ◽  
Author(s):  
G. Pointis ◽  
M.-T. Latreille ◽  
M.O. Richard ◽  
P.D. D'Athis ◽  
L. Cedard
Keyword(s):  
Sexual Behavior ◽  
Male Offspring ◽  
Progesterone Treatment ◽  
Natural Progesterone

scholarly journals The long-term effects of superovulation on fertility and sexual behavior of male offspring in mice

2014 ◽  
Vol 31 (5) ◽  
pp. 555-560 ◽  
Author(s):  
Zeng-Tao Wei ◽  
Xi-Lan Lu ◽  
Gang Zhang ◽  
Jing Yu ◽  
Hua Li ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Male Offspring ◽  
Long Term Effects

scholarly journals EPIGENOMIC EFFECTS OF EXPOSURE OF PREGNANT RATS TO LOW DOSE OF BISPHENOL A REGARDING THE NEUROENDOCRINE SYSTEM OF THE MALE F1 GENERATION (short communication)

2021 ◽  
pp. 23-28
Author(s):  
Alexander Reznikov ◽  
Olha Sachynska ◽  
Аnna Lymareva ◽  
Lyubov Polyakova
Keyword(s):  
Sexual Behavior ◽  
Bisphenol A ◽  
Low Dose ◽  
Male Offspring ◽  
Male Rats ◽  
Normal Male ◽  
Potential Hazard ◽  
Preoptic Nucleus ◽  
Female Behavior ◽  
Medial Preoptic Nucleus

Aim: To study the long-term effects of exposure of pregnant Wistar rats to low dose of bisphenol A (BPA) by measuring to the level of steroid hormones and sexual behavior of adult male offspring of the first generation. Material and research methods: BPA as part of the Dorfman gel was gavaged during the last week of pregnancy, when androgen-dependent sexual brain differentiation occurs, in a daily dose of 25 mcg/kg b.w. (threshold teratogenic dose). Male sexual behavior was evaluated by proceptive reactions, the duration of latent and refractory periods, the number of mounts, intromissions and ejaculations in the presence of a receptive female. Female sexual behavior was assessed by lordosis reactions of orchidectomized and activated by the introduction of estradiol and progesterone males in the presence of a normal male. A neuromorphological analysis of the sex-dimorphic area of the brain, the medial preoptic nucleus of the hypothalamus, was performed by histological examination and karyometry of neurons. Results: Prenatally administered BPA caused a very slight increase in the anogenital distance in newborn animals and did not affect the terms of puberty. The levels of testosterone and corticosterone in the blood plasma of males of 6 months of age did not differ from the control indices. At 10 months of age, all experimental males showed sharply weakened sexual motivation for mating with females, and in 4 from 5 animals, copulative components of sexual behavior were absent. There was no ejaculations in the 5th male as well, while numbers of the mounts without intromissions and ones with intromissions significantly reduced. In the BPA group, all descendants showed active female behavior in the presence of a normal male, which manifested in lordosis reactions and a high lordosis index. According to the histological study of medial preoptic nucleus, the activity of neurocytes in the male offspring of BPA-exposed females was significantly reduced, and their nuclei volume distribution was some different from the control. Conclusions: The data obtained indicate epigenetic disorders of the sexual brain differentiation program due to the prenatal exposure to BPA in dose that does not cause significant teratogenic effects. This should be taken into account when evaluating the potential hazard of BPA for reproductive health. Key words: bisphenol A, prenatal effect, male rats, sexual behavior, corticosterone, testosterone.

scholarly journals Inheritance of steroid-independent male sexual behavior in male offspring of B6D2F1 mice

2016 ◽  
Vol 80 ◽  
pp. 132-138 ◽  
Author(s):  
Christine M. McInnis ◽  
Paul J. Bonthuis ◽  
Emilie F. Rissman ◽  
Jin Ho Park
Keyword(s):  
Sexual Behavior ◽  
Male Offspring ◽  
Male Sexual Behavior

scholarly journals Endotoxin treatment of pregnant rats affects sexual behavior of the male offspring

1991 ◽  
Vol 49 (3) ◽  
pp. 647-649 ◽  
Author(s):  
S. Wijkstra ◽  
N. Valkhof ◽  
J.M. Koolhaas ◽  
G.A. Schuiling
Keyword(s):  
Sexual Behavior ◽  
Male Offspring ◽  
Pregnant Rats

Vaginal micronized natural progesterone treatment and reduced risk of recurrent preterm birth

2012 ◽  
Vol 55 (10) ◽  
pp. 699 ◽  
Author(s):  
Lindsay Ji Hyun Seong ◽  
Min Ji Kim ◽  
Yeri Lee ◽  
So-Yeon Yoon ◽  
Hyun-Hwa Cha ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Progesterone Treatment ◽  
Reduced Risk ◽  
Natural Progesterone
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