Maternal stress and pituitary–adrenal manipulations during pregnancy in rats: Effects on morphology and sexual behavior of male offspring.

1978 ◽  
Vol 92 (6) ◽  
pp. 1074-1083 ◽  
Author(s):  
Robert H. Chapman ◽  
Judith M. Stern
Keyword(s):  
Sexual Behavior ◽  
Maternal Stress ◽  
Male Offspring

scholarly journals Prenatal corticosterone exposure programs sex-specific adrenal adaptations in mouse offspring

2017 ◽  
Vol 232 (1) ◽  
pp. 37-48 ◽  
Author(s):  
J S M Cuffe ◽  
E L Turton ◽  
L K Akison ◽  
H Bielefeldt-Ohmann ◽  
K M Moritz
Keyword(s):  
Maternal Stress ◽  
Female Offspring ◽  
Male Offspring ◽  
Adrenal Weight ◽  
Zona Fasciculata ◽  
Foetal Development ◽  
Plaque Deposition ◽  
Acth Receptor ◽  
Long Term Impact

Maternal stress can impair foetal development and program sex-specific disease outcomes in offspring through the actions of maternally produced glucocorticoids, predominantly corticosterone (Cort) in rodents. We have demonstrated in mice that male but not female offspring prenatally exposed to Cort (33 µg/kg/h for 60 h beginning at E12.5) develop cardiovascular/renal dysfunction at 12 months. At 6 months of age, renal function was normal but male offspring had increased plasma aldosterone concentrations, suggesting that altered adrenal function may precede disease. This study investigated the long-term impact of prenatal exposure to Cort on adrenal growth, morphology and steroidogenic capacity as well as plasma Cort concentrations in offspring at postnatal day 30 (PN30), 6 months and 12 months of age. Prenatal Cort exposure decreased adrenal volume, particularly of the zona fasciculata, in male offspring at PN30 but increased both relative and absolute adrenal weight at 6 months of age. By 12 months of age, male Cort-exposed offspring had reduced absolute adrenal weight in association with increased adrenal plaque deposition (lipogenic pigmentation). Plasma Cort concentrations were elevated in male 6-month offspring but not at other ages. mRNA expression of Mc2r (ACTH receptor) was increased in males at PN30, and Cyp11a1 expression was decreased at 6 and 12 months of age. There were no changes in the adrenals of female Cort-exposed offspring. This study demonstrates that prenatal Cort exposure induces offspring adrenal gland dysfunction in an age- and sex-specific manner, which may contribute to long-term programmed disease in male offspring after maternal stress.

scholarly journals The long-term effects of superovulation on fertility and sexual behavior of male offspring in mice

2014 ◽  
Vol 31 (5) ◽  
pp. 555-560 ◽  
Author(s):  
Zeng-Tao Wei ◽  
Xi-Lan Lu ◽  
Gang Zhang ◽  
Jing Yu ◽  
Hua Li ◽  
...  
Keyword(s):  
Sexual Behavior ◽  
Male Offspring ◽  
Long Term Effects

scholarly journals EPIGENOMIC EFFECTS OF EXPOSURE OF PREGNANT RATS TO LOW DOSE OF BISPHENOL A REGARDING THE NEUROENDOCRINE SYSTEM OF THE MALE F1 GENERATION (short communication)

2021 ◽  
pp. 23-28
Author(s):  
Alexander Reznikov ◽  
Olha Sachynska ◽  
Аnna Lymareva ◽  
Lyubov Polyakova
Keyword(s):  
Sexual Behavior ◽  
Bisphenol A ◽  
Low Dose ◽  
Male Offspring ◽  
Male Rats ◽  
Normal Male ◽  
Potential Hazard ◽  
Preoptic Nucleus ◽  
Female Behavior ◽  
Medial Preoptic Nucleus

Aim: To study the long-term effects of exposure of pregnant Wistar rats to low dose of bisphenol A (BPA) by measuring to the level of steroid hormones and sexual behavior of adult male offspring of the first generation. Material and research methods: BPA as part of the Dorfman gel was gavaged during the last week of pregnancy, when androgen-dependent sexual brain differentiation occurs, in a daily dose of 25 mcg/kg b.w. (threshold teratogenic dose). Male sexual behavior was evaluated by proceptive reactions, the duration of latent and refractory periods, the number of mounts, intromissions and ejaculations in the presence of a receptive female. Female sexual behavior was assessed by lordosis reactions of orchidectomized and activated by the introduction of estradiol and progesterone males in the presence of a normal male. A neuromorphological analysis of the sex-dimorphic area of the brain, the medial preoptic nucleus of the hypothalamus, was performed by histological examination and karyometry of neurons. Results: Prenatally administered BPA caused a very slight increase in the anogenital distance in newborn animals and did not affect the terms of puberty. The levels of testosterone and corticosterone in the blood plasma of males of 6 months of age did not differ from the control indices. At 10 months of age, all experimental males showed sharply weakened sexual motivation for mating with females, and in 4 from 5 animals, copulative components of sexual behavior were absent. There was no ejaculations in the 5th male as well, while numbers of the mounts without intromissions and ones with intromissions significantly reduced. In the BPA group, all descendants showed active female behavior in the presence of a normal male, which manifested in lordosis reactions and a high lordosis index. According to the histological study of medial preoptic nucleus, the activity of neurocytes in the male offspring of BPA-exposed females was significantly reduced, and their nuclei volume distribution was some different from the control. Conclusions: The data obtained indicate epigenetic disorders of the sexual brain differentiation program due to the prenatal exposure to BPA in dose that does not cause significant teratogenic effects. This should be taken into account when evaluating the potential hazard of BPA for reproductive health. Key words: bisphenol A, prenatal effect, male rats, sexual behavior, corticosterone, testosterone.

Effects of maternal stress and perinatal fluoxetine exposure on behavioral outcomes of adult male offspring

Neuroscience ◽  
2016 ◽  
Vol 320 ◽  
pp. 281-296 ◽  
Author(s):  
V. Kiryanova ◽  
S.J. Meunier ◽  
H.A. Vecchiarelli ◽  
M.N. Hill ◽  
R.H. Dyck
Keyword(s):  
Adult Male ◽  
Maternal Stress ◽  
Behavioral Outcomes ◽  
Male Offspring
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