Regulation of Fibronectin by Platelet-Derived Growth Factors in Cultured Rat Thoracic Aortic Smooth Muscle Cells

1995 ◽  
Vol 2 (1) ◽  
pp. 63-69
Author(s):  
Chu-Shek Lo ◽  
Terry Tamaroglio ◽  
Jing Zhang
Keyword(s):  
Smooth Muscle ◽  
Growth Factors ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

Thrombin Induces Production of Growth Factors from Aortic Smooth Muscle Cells

1999 ◽  
Vol 82 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Alessandra Cucina ◽  
Valeria Borrelli ◽  
Anna Di Carlo ◽  
Sabrina Pagliei ◽  
Valentina Corvino ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Growth Factors ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle

Increase of PTP levels in vascular injury and in cultured aortic smooth muscle cells treated with specific growth factors

2004 ◽  
Vol 287 (5) ◽  
pp. H2201-H2208 ◽  
Author(s):  
Yingzi Chang ◽  
Daming Zhuang ◽  
Chunxiang Zhang ◽  
Aviv Hassid
Keyword(s):  
Smooth Muscle ◽  
Growth Factors ◽  
Smooth Muscle Cells ◽  
Vascular Injury ◽  
Muscle Cells ◽  
Ang Ii ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle ◽  
Protein Levels ◽  
Ptp 1B

Migration and proliferation of vascular smooth muscle cells are key events in injury-induced neointima formation. Several growth factors and ANG II are thought to be involved in neointima formation. A recent report indicated that vascular injury is associated with increased mRNA levels of protein tyrosine phosphatase (PTP)-1B (PTP-1B). In the present study, we tested the following hypotheses: 1) rat carotid artery injury induces the expression of PTP-1B, Src homology-2 domain phosphatase (SHP-2), and PTP-proline, glutamate, serine, and threonine sequence (PEST) protein; and 2) polypeptide growth factors as well as ANG II increase the levels of tyrosine phosphatases in cultured rat aortic smooth muscle cells. We found that vascular injury induced by balloon catheter increases the protein levels of aforementioned phosphatases and that these effects occur in a PTP specific, as well as temporally and regionally specific, manner. Moreover, treatment of cultured primary rat aortic smooth muscle cells with PDGF or bFGF, but not with IGF1, EGF, or ANG II, increases PTP-1B, SHP-2, and PTP-PEST protein levels. These results suggest that increased PDGF and bFGF levels, occurring after vascular injury, may induce expression of several PTPs.

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