Neuropsychiatric Symptoms in Alzheimer Disease, Vascular Dementia, and Mixed Dementia

2017 ◽  
Vol 17 (4-5) ◽  
pp. 127-134 ◽  
Author(s):  
Cassandra J. Anor ◽  
Sean O'Connor ◽  
Amardeep Saund ◽  
David F. Tang-Wai ◽  
Ron Keren ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Vascular Dementia ◽  
Neuropsychiatric Symptoms ◽  
Mixed Dementia

Somatic comorbidity in patients with dementia: Alzheimer Disease versus Mixed Dementia and Vascular Dementia

1998 ◽  
Vol 13 (S4) ◽  
pp. 274s-274s
Author(s):  
C.A. de Mendonca Lima ◽  
S. Leon Sanchez ◽  
I. Tschan ◽  
I. Simeone
Keyword(s):  
Alzheimer Disease ◽  
Vascular Dementia ◽  
Mixed Dementia ◽  
Somatic Comorbidity

Vascular lesions in mixed dementia, vascular dementia, and Alzheimer disease with cerebrovascular disease: The Kurihara Project

2012 ◽  
Vol 322 (1-2) ◽  
pp. 157-160 ◽  
Author(s):  
Kenichi Meguro ◽  
Naofumi Tanaka ◽  
Masahiro Nakatsuka ◽  
Kei Nakamura ◽  
Masayuki Satoh
Keyword(s):  
Alzheimer Disease ◽  
Cerebrovascular Disease ◽  
Vascular Dementia ◽  
Vascular Lesions ◽  
Mixed Dementia

scholarly journals Neuropsychiatric symptoms in vascular dementia: Epidemiologic and clinical aspects

2018 ◽  
Vol 12 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Marcelo Antônio Oliveira Santos ◽  
Lucas Soares Bezerra ◽  
Carolina da Cunha Correia ◽  
Igor Silvestre Bruscky
Keyword(s):  
Vascular Dementia ◽  
Neuropsychiatric Symptoms ◽  
Cognitive Disorders ◽  
General Term ◽  
Clinical Aspects ◽  
Mixed Dementia ◽  
Neuropsychiatric Inventory ◽  
Elderly Individuals ◽  
Epidemiological Features ◽  
Moderate Dementia

ABSTRACT Dementia is a general term for a heterogeneous group of organic neurodegenerative diseases. Cerebrovascular causes account for 20% of cases. Objective: To describe the clinical and epidemiological features of individuals aged >60 years diagnosed with vascular dementia (VD) or mixed dementia (MxD) in a referral hospital for dementia. Methods: A descriptive, retrospective study was carried out from 2014 to 2017 involving elderly individuals (≥60 years) with VA or MxD. Patients presenting other forms of dementia or in use of medication that mimics cognitive disorders were excluded. The 12-item Neuropsychiatric Inventory was used to assess neuropsychiatric symptoms (NPS). Results: 81.1% of the patients presented NPS and only 15% had two or more symptoms. Apathy was the most frequent NPS (56.6%). There was an association between CDR score 1 or 2 and NPS (OR = 6.16, 95% CI: 1.36-27.9, p = 0.02). Conclusion: Most patients had a single symptom, predominantly apathy. There was an association between mild-to-moderate dementia and NPS.

P1-428 Patterns of neuropsychiatric symptoms, in Alzheimer's dementia, mixed dementia, and vascular dementia

2004 ◽  
Vol 25 ◽  
pp. S221
Author(s):  
Sohel Sachak ◽  
Howard Feldman ◽  
Young Zhu ◽  
Joan Amatniek ◽  
Atul Mahableshwarkar
Keyword(s):  
Vascular Dementia ◽  
Neuropsychiatric Symptoms ◽  
Alzheimer’S Dementia ◽  
Mixed Dementia ◽  
Alzheimer's Dementia

Comparative Evolution of Alzheimer Disease, Vascular Dementia, and Mixed Dementia

1997 ◽  
Vol 54 (6) ◽  
pp. 697-703 ◽  
Author(s):  
J. V. Bowler ◽  
M. Eliasziw ◽  
R. Steenhuis ◽  
D. G. Munoz ◽  
R. Fry ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Vascular Dementia ◽  
Mixed Dementia ◽  
Comparative Evolution

Neuropsychiatric Symptoms and Antipsychotic Therapy in the Elderly Patients with Dementia

Psychiatry ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 6-15
Author(s):  
I. V. Kolykhalov
Keyword(s):  
Neuropsychiatric Symptoms ◽  
The Elderly ◽  
Psychotic Symptoms ◽  
Mixed Dementia ◽  
Short Term ◽  
Antipsychotic Therapy ◽  
Dementia Patients ◽  
Frequency Of Use ◽  
Number Of Patients ◽  
High Incidence

The objective of the study was to investigate syndromal-nosological specificities of neuropsychiatric symptoms (NPS) and the frequency of use of antipsychotics in patients with various types of dementias, institutionalized to geriatric units of mental hospitals.Patients and methods: a total of 106 in-patients of three psychogeriatric units were examined. The median age of patients is 75 years [69; 80].The diagnostic distribution of patients at the time of the examination was as follows: in 33 subjects (31.1%) Alzheimer’s disease (AD) was diagnosed, in 25 (23.6%) - mixed dementia (MD), in 32 (30.2%) - vascular dementia (VD) and in 16 (15.1%) patients had dementia of complex origin (DCO).Results: a high incidence (54.7%) of NPS was found in patients with dementia of various origins. The greatest number of patients with behavioral and psychotic symptoms was found in AD and MD. The proportion of dementia patients with such disorders in each of these types of dementia is about 70%, while in CGD and VD, the proportion of patients with NPS is noticeably smaller (30% and 40%, respectively). For the treatment of NPS, antipsychotics were most often prescribed, but their use caused adverse events (AEs) in 1/3 of cases. Patients with VD are most susceptible to the development of AE, and AD patients are the least susceptible.Conclusion: the study showed that NPS are one of the important components of dementia, regardless of the nosology and stage of the disease. The treatment of NPS in dementia is particularly challenging because, although the symptoms cause significant distress, there are currently no effective alternative therapies. The risk of AE can be minimized by carefully considering the indications for prescribing antipsychotics and their short-term use, regular monitoring of the patient’s condition, and educating caregivers.

scholarly journals P3-087: Late-onset Alzheimer disease and vascular dementia are precociously associated with a derangement in systemic oxidative balance

2015 ◽  
Vol 11 (7S_Part_14) ◽  
pp. P652-P653
Author(s):  
Arianna Romani ◽  
Eleonora Cremonini ◽  
Carlo Cervellati ◽  
Cristina Bosi ◽  
Monica Squerzanti ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Vascular Dementia ◽  
Late Onset ◽  
Oxidative Balance

An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia

2003 ◽  
Vol 25 (6) ◽  
pp. 1765-1782 ◽  
Author(s):  
Timo Erkinjuntti ◽  
Alexander Kurz ◽  
Gary W Small ◽  
Roger Bullock ◽  
Sean Lilienfeld ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Mixed Dementia ◽  
Open Label ◽  
Open Label Extension ◽  
Extension Trial

scholarly journals Does Diabetes Mellitus Alter the Onset and Clinical Course of Vascular Dementia?

2010 ◽  
Vol 23 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Santosh B. Murthy ◽  
Ali Jawaid ◽  
Salah U. Qureshi ◽  
Yogeshwar Kalkonde ◽  
Andrew M. Wilson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Dementia ◽  
Neuropsychiatric Symptoms ◽  
Disease Onset ◽  
Multiple Risk Factors ◽  
History Of ◽  
Dementing Illness ◽  
Multiple Variables ◽  
Rate Of Decline ◽  
The Individual

Background:Vascular dementia (VaD) is the second most common dementing illness. Multiple risk factors are associated with VaD, but the individual contribution of each to disease onset and progression is unclear. We examined the relationship between diabetes mellitus type 2 (DM) and the clinical variables of VaD.Methods:Data from 593 patients evaluated between June, 2003 and June, 2008 for cognitive impairment were prospectively entered into a database. We retrospectively reviewed the charts of 63 patients who fit the NINDSAIREN criteria for VaD. The patients were divided into those with DM (VaDDM, n = 29) and those without DM(VaD,n= 34). The groups were compared with regard to multiple variables.Results:Patients with DM had a significantly earlier onset of VaD (71.9 ± 6.54 vs. 77.2 ± 6.03,p< 0.001), a faster rate of decline per year on the mini mental state examination (MMSE; 3.60 ± 1.82 vs. 2.54 ± 1.60 points,p= 0.02), and a greater prevalence of neuropsychiatric symptoms at the time of diagnosis (62% vs. 21%,p= 0.02).Conclusions:A history of premorbid DM was associated with an earlier onset and faster cognitive deterioration in VaD. Moreover, DM was associated with neuropsychiatric symptoms in patients with VaD. A larger study is needed to verify these associations. It will be important to investigate whether better glycemic control will mitigate the potential effects of DM on VaD.

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