Vascular lesions in mixed dementia, vascular dementia, and Alzheimer disease with cerebrovascular disease: The Kurihara Project

2012 ◽  
Vol 322 (1-2) ◽  
pp. 157-160 ◽  
Author(s):  
Kenichi Meguro ◽  
Naofumi Tanaka ◽  
Masahiro Nakatsuka ◽  
Kei Nakamura ◽  
Masayuki Satoh
Keyword(s):  
Alzheimer Disease ◽  
Cerebrovascular Disease ◽  
Vascular Dementia ◽  
Vascular Lesions ◽  
Mixed Dementia

Neuropsychiatric Symptoms in Alzheimer Disease, Vascular Dementia, and Mixed Dementia

2017 ◽  
Vol 17 (4-5) ◽  
pp. 127-134 ◽  
Author(s):  
Cassandra J. Anor ◽  
Sean O'Connor ◽  
Amardeep Saund ◽  
David F. Tang-Wai ◽  
Ron Keren ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Vascular Dementia ◽  
Neuropsychiatric Symptoms ◽  
Mixed Dementia

Somatic comorbidity in patients with dementia: Alzheimer Disease versus Mixed Dementia and Vascular Dementia

1998 ◽  
Vol 13 (S4) ◽  
pp. 274s-274s
Author(s):  
C.A. de Mendonca Lima ◽  
S. Leon Sanchez ◽  
I. Tschan ◽  
I. Simeone
Keyword(s):  
Alzheimer Disease ◽  
Vascular Dementia ◽  
Mixed Dementia ◽  
Somatic Comorbidity

scholarly journals Cognitive and physical activity and dementia

Neurology ◽  
2019 ◽  
Vol 92 (12) ◽  
pp. e1322-e1330 ◽  
Author(s):  
Jenna Najar ◽  
Svante Östling ◽  
Pia Gudmundsson ◽  
Valter Sundh ◽  
Lena Johansson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Alzheimer Disease ◽  
Cerebrovascular Disease ◽  
Cox Regression ◽  
Cognitive Activity ◽  
Population Based ◽  
Physical Activities ◽  
Mixed Dementia ◽  
Reduced Risk

ObjectiveTo investigate whether cognitive and physical activities in midlife are associated with reduced risk of dementia and dementia subtypes in women followed for 44 years.MethodsA population-based sample of 800 women aged 38–54 years (mean age 47 years) was followed from 1968 to 2012. Cognitive (artistic, intellectual, manual, religious, and club) and physical activity were assessed at baseline. During follow-up, dementia (n = 194), Alzheimer disease (n = 102), vascular dementia (n = 27), mixed dementia (n = 41), and dementia with cerebrovascular disease (n = 81) were diagnosed according to established criteria based on information from neuropsychiatric examinations, informant interviews, hospital records, and registry data. Cox regression models were used with adjustment for age, education, socioeconomic status, hypertension, body mass index, cigarette smoking, diabetes mellitus, angina pectoris, stress, and major depression.ResultsWe found that cognitive activity in midlife was associated with a reduced risk of total dementia (hazard ratio [HR] 0.66; 95% confidence interval [CI] 0.49–0.89) and Alzheimer disease (HR 0.54; 95% CI 0.36–0.82) during follow-up. Physical activity in midlife was associated with a reduced risk of mixed dementia (HR 0.43; 95% CI 0.22–0.86) and dementia with cerebrovascular disease (HR 0.47; 95% CI 0.28–0.78). The results were similar after excluding those who developed dementia before 1990 (n = 21), except that physical activity was then also associated with reduced risk of total dementia (HR 0.67; 95% CI 0.46–0.99).ConclusionOur findings suggests that midlife cognitive and physical activities are independently associated with reduced risk of dementia and dementia subtypes. The results indicate that these midlife activities may have a role in preserving cognitive health in old age.

In the Spotlight or the Shadow of Alzheimer? The Role of Cerebrovascular Disease in Dementia

2005 ◽  
Vol 11 (4) ◽  
pp. 499-501
Author(s):  
Bruce Reed
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrovascular Disease ◽  
Vascular Dementia ◽  
Vascular Lesions ◽  
Specific Test ◽  
Cerebrovascular Lesions ◽  
Number Of Factors ◽  
Nun Study

Vascular Dementia: Cerebrovascular Mechanisms and Clinical Management. Robert H. Paul, Ronald Cohen, Brian R. Ott, and Stephen Salloway (Eds.). 2004. Totowa, NJ: Humana Press, 356 pp., $145.00, £91.00 (HB).Interest in how vascular factors contribute to dementia is ascendant, propelled by a number of factors. One is the widespread use of MRI, which is a highly sensitive (if not always specific) test for cerebrovascular lesions. A second is a string of epidemiological reports revealing that Alzheimer's disease shares many of the well established risk factors for cardiovascular and cerebrovascular disease (Skoog & Gustafson, 2003). Recent autopsy studies using cohorts obtained outside of the potentially winnowing influence of the Alzheimer's disease centers have reminded us that vascular lesions are common in patients with dementia (Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study, 2001). The Nun study report suggesting that infarcts create an additive or greater effect on mental function in concert with AD pathology (Snowdon et al., 1997) received particularly wide exposure and helped revive interest in combined effects of AD and ischemic lesions. Finally, the discovery that polymorphisms of the apoE gene, long of interest in cardiovascular disease, strongly modify the risk of AD suggested the possibility of shared pathophysiological mechanisms between AD and vascular dementia (Panza et al., 2004; Strittmatter & Roses, 1995). The volumeVascular Dementia, edited by Paul, Cohen, Ott and Salloway, is thus a timely resource for those interested in the numerous issues surrounding the role of vascular factors in dementia.

Comparative Evolution of Alzheimer Disease, Vascular Dementia, and Mixed Dementia

1997 ◽  
Vol 54 (6) ◽  
pp. 697-703 ◽  
Author(s):  
J. V. Bowler ◽  
M. Eliasziw ◽  
R. Steenhuis ◽  
D. G. Munoz ◽  
R. Fry ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Vascular Dementia ◽  
Mixed Dementia ◽  
Comparative Evolution

The Spectrum of Cerebrovascular Disease and Associated Cognitive Decline

2019 ◽  
pp. 574-599
Author(s):  
Victoria J. Williams ◽  
Steven E. Arnold ◽  
David H. Salat
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Cerebrovascular Disease ◽  
Cognitive Decline ◽  
Vascular Dementia ◽  
Structure And Function ◽  
Vascular Risk Factors ◽  
Vascular Health ◽  
Vascular Risk ◽  
And Function

Throughout the lifespan, common variations in systemic health and illness contribute to alterations in vasculature structure and function throughout the body, significantly increasing risk for cardiovascular and cerebrovascular disease (CVD). CVD is a prevalent cause of mortality in late life; it also promotes brain alterations, contributing to cognitive decline and, when severe, vascular dementia. Even prior to diseased states, individual variation in CVD risk is associated with structural and functional brain alterations. Yet, how cumulative asymptomatic alterations in vessel structure and function contribute to more subtle changes in brain tissue integrity and function that emerge in late life is unclear. Finally, vascular risk factors are associated with the clinical progression of neurodegenerative diseases such as Alzheimer’s disease (AD); however, recent theory posits that vascular degeneration may serve a contributory role in these conditions. This chapter reviews how lifespan changes in vascular health contribute to degenerative changes in neural tissue and the subsequent development of cognitive impairment and/or vascular dementia. It first discusses associations between vascular risk factors and cognition and also how declining vascular health may lead to cognitive impairment and dementia. Next, it identifies basic aspects of cerebrovascular anatomy and physiology sustaining tissue health and discusses how vulnerabilities of this system contribute to neurodegenerative changes. Finally, it reviews evidence of vascular contributions to AD and presents ideas for future research to better understand the full spectrum of cerebrovascular contributions to brain aging, cognitive decline, and dementia.

scholarly journals P3-087: Late-onset Alzheimer disease and vascular dementia are precociously associated with a derangement in systemic oxidative balance

2015 ◽  
Vol 11 (7S_Part_14) ◽  
pp. P652-P653
Author(s):  
Arianna Romani ◽  
Eleonora Cremonini ◽  
Carlo Cervellati ◽  
Cristina Bosi ◽  
Monica Squerzanti ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Vascular Dementia ◽  
Late Onset ◽  
Oxidative Balance

An open-label extension trial of galantamine in patients with probable vascular dementia and mixed dementia

2003 ◽  
Vol 25 (6) ◽  
pp. 1765-1782 ◽  
Author(s):  
Timo Erkinjuntti ◽  
Alexander Kurz ◽  
Gary W Small ◽  
Roger Bullock ◽  
Sean Lilienfeld ◽  
...  
Keyword(s):  
Vascular Dementia ◽  
Mixed Dementia ◽  
Open Label ◽  
Open Label Extension ◽  
Extension Trial
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