The Effect of Intra-Dialytic Exercise on Inflammation and Blood Endotoxin Levels

2017 ◽  
Vol 44 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Jonathan Wong ◽  
Philip Davis ◽  
Ashish Patidar ◽  
Yonglong Zhang ◽  
Enric Vilar ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Acute Effect ◽  
Tumour Necrosis Factor Α ◽  
Healthy Individuals ◽  
C Reactive Protein ◽  
Intense Exercise ◽  
Reactive Protein ◽  
Before And After ◽  
Factor Α ◽  
Necrosis Factor

Background: In healthy individuals, an acute inflammatory response occurs after intense exercise due to gut ischaemia and intestinal bacterial endotoxin translocation into the bloodstream. This process maybe exacerbated in patients who exercise during dialysis due to large volume shifts experienced by many during haemodialysis (HD). The acute effect of intra-dialytic exercise on blood endotoxins and inflammation is not known. Method: The effect of intra-dialytic exercise on blood endotoxin and inflammation was investigated in 10 patients and compared with resting haemodialysis. Blood was measured for endotoxin and inflammatory biomarkers before and after dialysis. Result: With the exception of one sample, all samples tested negative for endotoxin. Intra-dialytic exercise attenuated the rise of interleukin-6, tumour necrosis factor-α and high-sensitivity C-reactive protein after the HD procedure. Conclusion: Intra-dialytic exercise was not associated with an observable rise in blood endotoxin, although it may ameliorate the inflammatory effects of the HD procedure. Larger studies are needed to confirm this finding.

Mediator effects of parameters of inflammation and neurogenesis from a N-acetyl cysteine clinical-trial for bipolar depression

2018 ◽  
Vol 30 (6) ◽  
pp. 334-341 ◽  
Author(s):  
Bruna Panizzutti ◽  
Chiara Bortolasci ◽  
Kyoko Hasebe ◽  
Srisaiyini Kidnapillai ◽  
Laura Gray ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Tumour Necrosis ◽  
Bipolar Depression ◽  
Tumour Necrosis Factor Α ◽  
C Reactive Protein ◽  
Open Label ◽  
Reactive Protein ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

AbstractObjectiveThis study aimed to explore effects of adjunctive treatment with N-acetyl cysteine (NAC) on markers of inflammation and neurogenesis in bipolar depression.MethodsThis is a secondary analysis of a placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, and week 32 of the open-label and maintenance phases of the clinical trial to determine changes in interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following adjunctive NAC treatment, and to explore mediation and moderator effects of the listed markers.ResultsLevels of brain-derived neurotrophic factor (BDNF), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukins (IL) -6, 8, or 10 were not significantly changed during the course of the trial or specifically in the open-label and maintenance phases. There were no mediation or moderation effects of the biological factors on the clinical parameters.ConclusionThe results suggest that these particular biological parameters may not be directly involved in the therapeutic mechanism of action of adjunctive NAC in bipolar depression.

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