scholarly journals Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α

2015 ◽  
Vol 21 (5) ◽  
pp. 642-649 ◽  
Author(s):  
D Baumeister ◽  
R Akhtar ◽  
S Ciufolini ◽  
C M Pariante ◽  
V Mondelli
Keyword(s):  
Tumour Necrosis Factor ◽  
Childhood Trauma ◽  
Interleukin 6 ◽  
Tumour Necrosis ◽  
Meta Analysis ◽  
Tumour Necrosis Factor Α ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Effect of physical activity promotion on adiponectin, leptin and other inflammatory markers in prediabetes: a systematic review and meta-analysis of randomized controlled trials

2020 ◽  
Author(s):  
Radhika Aditya Jadhav ◽  
G. Arun Maiya ◽  
Aditi Hombali ◽  
Shashikiran Umakanth ◽  
K. N. Shivashankar
Keyword(s):  
Physical Activity ◽  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Meta Analysis ◽  
Physical Activity Promotion ◽  
Tumour Necrosis Factor Α ◽  
Reactive Protein ◽  
Activity Promotion ◽  
Factor Α ◽  
Necrosis Factor

Abstract Aims Inflammatory stage in prediabetes is associated with increase in level of adipokines and pro-inflammatory cytokines. Physical activity promotion considered as a first-line therapeutic strategy to treat prediabetes. We have conducted the systematic review and meta-analysis to strengthen the evidence on the impact of physical activity promotion on inflammatory markers in prediabetes. Methods Studies were identified using electronic search and manual search techniques by choosing keywords for prediabetes, physical activity and inflammatory marker. Randomized controlled trials on individuals diagnosed with prediabetes and provided intervention in the form of physical activity were included in this review. Adiponectin, leptin, C-reactive protein, interleukin-6 and tumour necrosis factor-α were the considered outcome measures. Results Our search retrieved 1,688 citations, 31 full-text articles assessed for eligibility of inclusion. Nine studies satisfied the pre-specified criteria for inclusion. Meta-analysis found that physical activity with or without dietary or lifestyle modification reduces level of leptin (MD−2.11 ng/mL, 95% CI −3.81 – −0.42) and interleukin-6 (MD −0.15 pg/mL, 95% CI −0.25–−0.04). It has no effect on level of adiponectin (MD 0.26 µg/mL, 95% CI −0.42– 0.93), C-reactive protein (MD −0.05 mg/L, 95% CI −0.33–0.23) and tumour necrosis factor-α (MD 0.67 pg/mL, 95% CI −2.56–3.89). Conclusions This review suggests that physical activity promotion with dietary and lifestyle modification may reduce the level of leptin and interleukin-6 but are uncertain if there is any effect on levels of adiponectin, C-reactive protein and tumour necrosis factor-α in the individuals with prediabetes.

C-reactive protein, fibrinogen, interleukin-6 and tumour necrosis factor-α in the prognostic classification of unstable angina pectoris

2001 ◽  
Vol 33 (1) ◽  
pp. 37-47 ◽  
Author(s):  
Heli Koukkunen ◽  
Karri Penttilä ◽  
Art Kemppainen ◽  
Matti Halinen ◽  
Ilkka Penttilä ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Unstable Angina ◽  
Interleukin 6 ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Α ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Effects of antihypertensive treatment on systemic inflammation, oxidative stress and proinflammatory cytokine levels

2020 ◽  
Vol 11 (4) ◽  
pp. 536-541
Author(s):  
T. V. Ashcheulova ◽  
N. N. Gerasimchuk ◽  
O. N. Kovalyova ◽  
K. N. Kompaniiets ◽  
O. V. Honchar
Keyword(s):  
Tumour Necrosis Factor ◽  
Tumour Necrosis ◽  
Type I ◽  
Soluble Receptor ◽  
Tumour Necrosis Factor Α ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Hypertension in its origin is a heterogeneous and multisystemic disease. Evaluation of oxidative stress activity based on the level of 8-iso-PgF2α, proinflammatory activity based on tumour necrosis factor-α, its type I soluble receptor, and C-reactive protein levels is relevant for further understanding of pathogenesis of hypertension and improvement of the early diagnostics of heart failure. 186 hypertensive patients were observed during a 2-months course of treatment, aged 30 to 65 years. Serum levels of 8-iso-PgF2α (n = 34), tumour necrosis factor-α and its type I soluble receptor were determined by ELISA before and after course of treatment. C-reactive protein level was determined by biochemical method. The control group included 16 clinically healthy individuals, aged 27 to 55 years. Hypertensive patients enrolled into the study were randomized into three groups that received different protocols of combined anti-hypertensive therapy: I clinical group – а combination of bisoprolol and indapamid, II – а combination of lacidipine and candesartan, III – а combination of fosinopril sodium and hydrochlorothiazide. On the background of combined antihypertensive therapy, we observed favourable dynamics of 8-iso-PgF2α, tumour necrosis factor-α and its type I soluble receptor, and C-reactive protein levels. Taking into account the insignificance of the correlations revealed, a one-factor dispersion analysis was applied which allowed us to determine the influence of the grade and duration of hypertension on the dynamics of the studied parameters. It has been found that the grade of hypertension is related to an increase in TNF-α and 8-iso-PgF2α serum levels, but not in TNF-α type I soluble receptor, and the duration of hypertension is related to an increase in C-reactive protein, TNF-α and its type I soluble receptor levels, with no relation to the level of 8-iso-PgF2α. Thus, oxidative stress possibly promotes the activation of potentially damaging immune mechanisms mediated by proinflammatory cytokines, nonspecific inflammation and drives the further progression of lesions in the target organs.

Effects of concurrent training on interleukin-6, tumour necrosis factor-alpha and C-reactive protein in middle-aged men

2011 ◽  
Vol 29 (14) ◽  
pp. 1573-1581 ◽  
Author(s):  
Cleiton Augusto Libardi ◽  
Giovana Verginia Souza ◽  
Arthur Fernandes GÁspari ◽  
Claudinei Ferreira Dos Santos ◽  
Sabrina Toffoli Leite ◽  
...  
Keyword(s):  
Tumour Necrosis Factor ◽  
Interleukin 6 ◽  
Tumour Necrosis ◽  
Tumour Necrosis Factor Alpha ◽  
Concurrent Training ◽  
C Reactive Protein ◽  
Necrosis Factor Alpha ◽  
Reactive Protein ◽  
Factor Alpha ◽  
Necrosis Factor

Differential effect of selective block of α2-adrenoreceptors on plasma levels of tumour necrosis factor-α, interleukin-6 and corticosterone induced by bacterial lipopolysaccharide in mice

1995 ◽  
Vol 144 (3) ◽  
pp. 457-462 ◽  
Author(s):  
G Haskó ◽  
I J Elenkov ◽  
V Kvetan ◽  
E S Vizi
Keyword(s):  
Tumour Necrosis Factor ◽  
Interleukin 6 ◽  
Plasma Levels ◽  
Tumour Necrosis ◽  
Endotoxin Shock ◽  
Bacterial Lipopolysaccharide ◽  
Tumour Necrosis Factor Α ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Abstract The effect of selective block of α2-adrenoreceptors on plasma levels of tumour necrosis factor-α (TNF-α), interleukin-6 (IL-6) and corticosterone induced by bacterial lipopolysaccharide (LPS) was investigated in mice using ELISA and RIA. It was found that the LPS-induced TNF-α response was significantly blunted in mice pretreated with CH-38083, a novel and highly selective α2-adrenoreceptor antagonist (the α2/α1 ratio is >2000). In contrast, LPS-induced increases in both corticosterone and IL-6 plasma levels were further increased by CH-38083. Since it has recently been shown that the selective block of α2-adrenoreceptors located on noradrenergic axon terminals resulted in an increase in the release of noradrenaline (NA), both in the central and peripheral nervous systems, and, in our experiments, that propranolol prevented the effect of α2-adrenoreceptor blockade on TNF-α plasma levels induced by LPS, it seems likely that the excessive stimulation by NA of β-adrenoreceptors located on cytokine-secreting immune cells is responsible for this action. Since it is generally accepted that increased production of TNF-α is involved in the pathogenesis of inflammation and endotoxin shock on the one hand, and corticosterone and even IL-6 are known to possess anti-inflammatory properties on the other hand, it is suggested that the selective block of α2-adrenoreceptors might be beneficial in the treatment of inflammation and/or endotoxin shock. Journal of Endocrinology (1995) 144, 457–462

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