scholarly journals Metastatic Cutaneous Squamous Cell Carcinoma with Gastrointestinal Involvement: A Case Report

2016 ◽  
Vol 9 (3) ◽  
pp. 869-873 ◽  
Author(s):  
Brian Schwartz ◽  
Mitchell Schwartz
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Metastatic Lesion ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Gastrointestinal Involvement ◽  
Regional Lymph Nodes ◽  
Metastatic Squamous Cell Carcinoma ◽  
Bowel Lesion ◽  
Disease Free

Metastatic squamous cell carcinoma (SCC) involving the gastrointestinal tract as the sole site of metastatic disease is exceedingly rare. We report a patient with known cutaneous SCC that metastasized to regional lymph nodes who, after therapy, appeared to be disease free until a small metastatic lesion was identified on colonoscopy within a diverticular orifice. He was subsequently noted to have more diffuse gastrointestinal involvement, including a small bowel lesion not previously identified on imaging. The presence of a gastrointestinal metastatic lesion in this setting should prompt consideration to exclude other synchronous lesions and the need for possible additional systemic therapy.

Prognostic significance of disease-free interval in head and neck cutaneous squamous cell carcinoma with nodal metastases

Head & Neck ◽  
2012 ◽  
Vol 35 (8) ◽  
pp. 1138-1143 ◽  
Author(s):  
Ardalan Ebrahimi ◽  
Jonathan R. Clark ◽  
Nazanin Ahmadi ◽  
Carsten E. Palme ◽  
Gary J. Morgan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Nodal Metastases ◽  
Disease Free Interval ◽  
Free Interval ◽  
Disease Free

Pemphigus foliaceus developing after metastasis of cutaneous squamous cell carcinoma to regional lymph nodes

2001 ◽  
Vol 45 (5) ◽  
pp. 767-770 ◽  
Author(s):  
Makoto Inaoki ◽  
Kenzo Kaji ◽  
Shinobu Furuse ◽  
Akihide Fujimoto ◽  
Nahoko Komatsu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Pemphigus Foliaceus ◽  
Regional Lymph Nodes

Feline cutaneous squamous cell carcinoma of the nasal planum and the pinnae: 61 cases

1997 ◽  
Vol 33 (4) ◽  
pp. 329-332 ◽  
Author(s):  
SE Lana ◽  
GK Ogilvie ◽  
SJ Withrow ◽  
RC Straw ◽  
KS Rogers
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Medical Records ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Disease Free Interval ◽  
Free Interval ◽  
Treatment Type ◽  
Methods Of Treatment ◽  
Disease Free

Cutaneous squamous cell carcinoma is a common tumor in cats and frequently occurs on the nasal planum and the pinnae. The medical records of 61 cats were reviewed for this retrospective study. Typical presentation was an older (median age, 12 years) cat with an erythematous, crusty, and erosive lesion. Methods of treatment included surgery, radiation, and cryotherapy. Disease-free interval and survival time were calculated for each case and grouped according to lesion location and treatment type. All treatments were found to be effective, with surgery resulting in the longest disease-free interval (median, 594 days).

scholarly journals Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial

2018 ◽  
Vol 36 (13) ◽  
pp. 1275-1283 ◽  
Author(s):  
Sandro Virgilio Porceddu ◽  
Mathias Bressel ◽  
Michael Geoffrey Poulsen ◽  
Adam Stoneley ◽  
Michael John Veness ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Postoperative Radiotherapy ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Phase Iii ◽  
Disease Free

Purpose To report the results of the Trans Tasman Radiation Oncology Group randomized phase III trial designed to determine whether the addition of concurrent chemotherapy to postoperative radiotherapy (CRT) improved locoregional control in patients with high-risk cutaneous squamous cell carcinoma of the head and neck. Patients and Methods The primary objective was to determine whether there was a difference in freedom from locoregional relapse (FFLRR) between 60 or 66 Gy (6 to 6.5 weeks) with or without weekly carboplatin (area under the curve 2) after resection of gross disease. Secondary efficacy objectives were to compare disease-free survival and overall survival. Results Three hundred twenty-one patients were randomly assigned, with 310 patients commencing allocated treatment (radiotherapy [RT] alone, n = 157; CRT, n = 153). Two hundred thirty-eight patients (77%) had high-risk nodal disease, 59 (19%) had high-risk primary or in-transit disease, and 13 (4%) had both. Median follow-up was 60 months. Median RT dose was 60 Gy, with 84% of patients randomly assigned to CRT completing six cycles of carboplatin. The 2- and 5-year FFLRR rates were 88% (95% CI, 83% to 93%) and 83% (95% CI, 77% to 90%), respectively, for RT and 89% (95% CI, 84% to 94%) and 87% (95% CI, 81% to 93%; hazard ratio, 0.84; 95% CI, 0.46 to 1.55; P = .58), respectively, for CRT. There were no significant differences in disease-free or overall survival. Locoregional failure was the most common site of first treatment failure, with isolated distant metastases as the first site of failure seen in 7% of both arms. Treatment was well tolerated in both arms, with no observed enhancement of RT toxicity with carboplatin. Grade 3 or 4 late toxicities were infrequent. Conclusion Although surgery and postoperative RT provided excellent FFLRR, there was no observed benefit with the addition of weekly carboplatin.

scholarly journals Primary Invasive Squamous Cell Carcinoma of the Nipple

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Avani A. Pendse ◽  
Siobhan M. O’Connor
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Excisional Biopsy ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Response To Therapy ◽  
Invasive Squamous Cell Carcinoma ◽  
Regional Lymph Nodes ◽  
Younger Women ◽  
The Right

Squamous cell carcinoma is one of the most common cutaneous cancers; however, primary squamous cell carcinoma of the nipple is extremely rare. Among the few reported cases, the majority have occurred in older women with rare cases seen in younger women and male patients. Our patient presented with an exophytic mass of the right nipple while pregnant. A superficial biopsy was reviewed at an outside institution and then at our institution and diagnosed as squamous papilloma and then as hyperkeratosis of the nipple, respectively. The subsequent excisional biopsy revealed multiple nests of tumor cells extending into the dermis with associated chronic inflammatory infiltrate, and the lesion was diagnosed as a primary invasive squamous cell carcinoma of the nipple. Following that, a wide local excision of the excision site and sampling of the regional lymph nodes were negative for carcinoma. Due to the rarity of this diagnosis, it is not known whether prognosis and response to therapy differ from cutaneous squamous cell carcinoma at other sites. Therefore, risk stratification and therapy have been based on those for cutaneous squamous cell carcinoma.

scholarly journals Prognostic Factors in Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck

2016 ◽  
Vol 95 (10-11) ◽  
pp. 1-10 ◽  
Author(s):  
Gideon Bachar ◽  
Aviram Mizrachi ◽  
Naomi Rabinovics ◽  
Dan Guttman ◽  
Thomas Shpitzer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Independent Predictor ◽  
Tertiary Care ◽  
Prognostic Significance ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Significant Difference ◽  
Disease Free

Metastatic cutaneous squamous cell carcinoma (SCC) of the head and neck poses a significant therapeutic challengedue to its aggressive biologic behavior. We conducted a retrospective study of71 patients—58 men and 13 women, aged 28 to 88 years (mean: 71)—who had been treated atour university-affiliated tertiary care medical center for metastatic cutaneous SCCover a 15-year period. In addition to demographic data, we compiled and analyzed information on tumor characteristics, the site and extent of metastasis, treatment, follow-up, and outcome. Among the tumor factors, poorly differentiated carcinoma was an independent predictor of poorer disease-free survival, and olderage was found to be an independent predictor of poorer overall survival. We found no significant difference in disease-free or disease-specific survival among patients with parotid involvement, neck involvement, or both. In our series, the site of nodal involvement appeared to have no prognostic significance in patients with metastatic cutaneous SCC of the head and neck.

scholarly journals PD-L1 expression predicts longer disease free survival in high risk head and neck cutaneous squamous cell carcinoma

Pathology ◽  
2017 ◽  
Vol 49 (5) ◽  
pp. 499-505 ◽  
Author(s):  
Edward Roper ◽  
Trina Lum ◽  
Carsten E. Palme ◽  
Bruce Ashford ◽  
Sydney Ch'ng ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Disease Free Survival ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Free Survival ◽  
Disease Free
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