Prognostic significance of disease-free interval in head and neck cutaneous squamous cell carcinoma with nodal metastases

Head & Neck ◽  
2012 ◽  
Vol 35 (8) ◽  
pp. 1138-1143 ◽  
Author(s):  
Ardalan Ebrahimi ◽  
Jonathan R. Clark ◽  
Nazanin Ahmadi ◽  
Carsten E. Palme ◽  
Gary J. Morgan ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Nodal Metastases ◽  
Disease Free Interval ◽  
Free Interval ◽  
Disease Free

Feline cutaneous squamous cell carcinoma of the nasal planum and the pinnae: 61 cases

1997 ◽  
Vol 33 (4) ◽  
pp. 329-332 ◽  
Author(s):  
SE Lana ◽  
GK Ogilvie ◽  
SJ Withrow ◽  
RC Straw ◽  
KS Rogers
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Medical Records ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Disease Free Interval ◽  
Free Interval ◽  
Treatment Type ◽  
Methods Of Treatment ◽  
Disease Free

Cutaneous squamous cell carcinoma is a common tumor in cats and frequently occurs on the nasal planum and the pinnae. The medical records of 61 cats were reviewed for this retrospective study. Typical presentation was an older (median age, 12 years) cat with an erythematous, crusty, and erosive lesion. Methods of treatment included surgery, radiation, and cryotherapy. Disease-free interval and survival time were calculated for each case and grouped according to lesion location and treatment type. All treatments were found to be effective, with surgery resulting in the longest disease-free interval (median, 594 days).

scholarly journals Prognostic Factors in Metastatic Cutaneous Squamous Cell Carcinoma of the Head and Neck

2016 ◽  
Vol 95 (10-11) ◽  
pp. 1-10 ◽  
Author(s):  
Gideon Bachar ◽  
Aviram Mizrachi ◽  
Naomi Rabinovics ◽  
Dan Guttman ◽  
Thomas Shpitzer ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Independent Predictor ◽  
Tertiary Care ◽  
Prognostic Significance ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Significant Difference ◽  
Disease Free

Metastatic cutaneous squamous cell carcinoma (SCC) of the head and neck poses a significant therapeutic challengedue to its aggressive biologic behavior. We conducted a retrospective study of71 patients—58 men and 13 women, aged 28 to 88 years (mean: 71)—who had been treated atour university-affiliated tertiary care medical center for metastatic cutaneous SCCover a 15-year period. In addition to demographic data, we compiled and analyzed information on tumor characteristics, the site and extent of metastasis, treatment, follow-up, and outcome. Among the tumor factors, poorly differentiated carcinoma was an independent predictor of poorer disease-free survival, and olderage was found to be an independent predictor of poorer overall survival. We found no significant difference in disease-free or disease-specific survival among patients with parotid involvement, neck involvement, or both. In our series, the site of nodal involvement appeared to have no prognostic significance in patients with metastatic cutaneous SCC of the head and neck.

Prognostic significance of nodal ratio in cutaneous squamous cell carcinoma of the head and neck

2012 ◽  
Vol 270 (2) ◽  
pp. 647-653 ◽  
Author(s):  
Aviram Mizrachi ◽  
Tuvia Hadar ◽  
Naomi Rabinovics ◽  
Thomas Shpitzer ◽  
Dan Guttman ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Nodal Ratio

scholarly journals Analysis of selected risk factors for nodal metastases in head and neck cutaneous squamous cell carcinoma

2014 ◽  
Vol 272 (10) ◽  
pp. 3007-3012 ◽  
Author(s):  
Mateusz Szewczyk ◽  
Jakub Pazdrowski ◽  
Paweł Golusiński ◽  
Aleksandra Dańczak-Pazdrowska ◽  
Sławomir Marszałek ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Nodal Metastases

Number of nodal metastases and prognosis in metastatic cutaneous squamous cell carcinoma of the head and neck

2019 ◽  
Vol 89 (7-8) ◽  
pp. 863-867 ◽  
Author(s):  
Ashish Sood ◽  
James Wykes ◽  
David Roshan ◽  
Laura Y. Wang ◽  
John McGuinness ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Nodal Metastases

scholarly journals Postoperative Concurrent Chemoradiotherapy Versus Postoperative Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma of the Head and Neck: The Randomized Phase III TROG 05.01 Trial

2018 ◽  
Vol 36 (13) ◽  
pp. 1275-1283 ◽  
Author(s):  
Sandro Virgilio Porceddu ◽  
Mathias Bressel ◽  
Michael Geoffrey Poulsen ◽  
Adam Stoneley ◽  
Michael John Veness ◽  
...  
Keyword(s):  
Overall Survival ◽  
Squamous Cell Carcinoma ◽  
High Risk ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Postoperative Radiotherapy ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Phase Iii ◽  
Disease Free

Purpose To report the results of the Trans Tasman Radiation Oncology Group randomized phase III trial designed to determine whether the addition of concurrent chemotherapy to postoperative radiotherapy (CRT) improved locoregional control in patients with high-risk cutaneous squamous cell carcinoma of the head and neck. Patients and Methods The primary objective was to determine whether there was a difference in freedom from locoregional relapse (FFLRR) between 60 or 66 Gy (6 to 6.5 weeks) with or without weekly carboplatin (area under the curve 2) after resection of gross disease. Secondary efficacy objectives were to compare disease-free survival and overall survival. Results Three hundred twenty-one patients were randomly assigned, with 310 patients commencing allocated treatment (radiotherapy [RT] alone, n = 157; CRT, n = 153). Two hundred thirty-eight patients (77%) had high-risk nodal disease, 59 (19%) had high-risk primary or in-transit disease, and 13 (4%) had both. Median follow-up was 60 months. Median RT dose was 60 Gy, with 84% of patients randomly assigned to CRT completing six cycles of carboplatin. The 2- and 5-year FFLRR rates were 88% (95% CI, 83% to 93%) and 83% (95% CI, 77% to 90%), respectively, for RT and 89% (95% CI, 84% to 94%) and 87% (95% CI, 81% to 93%; hazard ratio, 0.84; 95% CI, 0.46 to 1.55; P = .58), respectively, for CRT. There were no significant differences in disease-free or overall survival. Locoregional failure was the most common site of first treatment failure, with isolated distant metastases as the first site of failure seen in 7% of both arms. Treatment was well tolerated in both arms, with no observed enhancement of RT toxicity with carboplatin. Grade 3 or 4 late toxicities were infrequent. Conclusion Although surgery and postoperative RT provided excellent FFLRR, there was no observed benefit with the addition of weekly carboplatin.

Prognostic Significance of TP53 Mutations in Oral Squamous Cell Carcinoma with Human Papilloma virus Infection

2007 ◽  
Vol 22 (4) ◽  
pp. 252-257 ◽  
Author(s):  
R.J. Kozomara ◽  
M.V. Brankovic-Magic ◽  
N.R. Jovic ◽  
S.M. Stosic ◽  
Z.M. Magic
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Postoperative Radiotherapy ◽  
Hpv Infection ◽  
Disease Free Interval ◽  
Tp53 Mutations ◽  
Free Interval ◽  
Disease Free

Purpose The aim of this study was to analyze the prognostic impact of mutated TP53 in patients with oral squamous cell carcinoma (OSCC) whose tumors were infected with human papillomavirus (HPV). Methods Thirty-two HPV-positive OSCC patients were included. Most of them were clinically classified as stage III (n=29). All patients underwent postoperative radiotherapy (follow-up from 12 to 60 months, median 32). There were 21 relapses. DNA was isolated by phenol extraction from tumor tissue. HPV DNA (type 16, 18, 31, 33) was detected in genomic DNA of the tumors by the PCR-PAGE method. TP53 mutations (exons 4–8) were detected by the PCR-SSCP method. Results A statistically significant difference in the number of relapses in HPV-infected (13/21) versus HPV-infected and TP53-mutated (8/8) patients was observed. Patients with both TP53 mutation and HPV infection had a significantly shorter disease-free interval than patients with HPV infection only (median 6 versus 31 months, respectively). Conclusions TP53 mutations are associated with a higher risk of relapse and contribute to an even worse prognosis of patients with OSCC when the tumors are HPV infected. The shorter disease-free interval in patients with TP53 mutations indicates that the response to postoperative radiotherapy may be influenced by TP53 status. The presence of both HPV infection and TP53 mutations may define a particular group of tumors with a more aggressive phenotype in advanced OSCC.

Association of 8p23 Deletions with Poor Survival in Head and Neck Cancer

2001 ◽  
Vol 124 (4) ◽  
pp. 451-455 ◽  
Author(s):  
Ulrike Bockmühl ◽  
Chandramohan S. Ishwad ◽  
Robert E. Ferrell ◽  
Susanne M. Gollin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Loss Of Heterozygosity ◽  
Allelic Loss ◽  
Disease Specific Survival ◽  
Disease Free Interval ◽  
Free Interval ◽  
Disease Free ◽  
Disease Specific

OBJECTIVE: Allelic loss at 8p23 occurs frequently in head and neck squamous cell carcinoma. The objective of this study was to determine the prognostic importance of 8p23 loss. STUDY DESIGN AND SETTINGS: We tested 51 primary tumors and 19 lymph node metastases for loss of heterozygosity with 7 microsatellite polymorphisms at 8p23 and correlated the results with disease-free interval and disease-specific survival. RESULTS: The Kaplan-Meier analysis demonstrated statistically significant association of 8p23 allelic loss with both shorter disease-free interval and disease-specific survival. For the pN stage, the log-rank test indicated significance in correlation with the disease-free interval, whereas the pT stage showed a significant correlation with disease-specific survival. Multivariate analysis identified loss of heterozygosity at 8p23 as independent prognostic marker for disease-free interval. CONCLUSION: Our data suggest that 8p23 allelic loss is associated with poor prognosis in head and neck squamous cell carcinoma and could be useful refining diagnosis of these tumors.

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