scholarly journals Maximizing the Benefit-Cost Ratio of Anthracyclines in Metastatic Breast Cancer: Case Report of a Patient with a Complete Response to High-Dose Doxorubicin

2016 ◽  
Vol 9 (3) ◽  
pp. 840-846 ◽  
Author(s):  
Kevin Shee ◽  
Alan T. Kono ◽  
Susan P. D'Anna ◽  
Mark A. Seltzer ◽  
Xiaoying Lu ◽  
...  
Keyword(s):  
Metastatic Breast ◽  
Breast Cancer Case ◽  
Complete Response ◽  
Cancer Case ◽  
Cost Ratio ◽  
High Dose ◽  
Benefit Cost Ratio ◽  
Benefit Cost

Despite the clinical efficacy of anthracycline agents such as doxorubicin, dose-limiting cardiac toxicities significantly limit their long-term use. Here, we present the case of a 33-year-old female patient with extensive metastatic ER+/PR+/HER2– mucinous adenocarcinoma of the breast, who was started on doxorubicin/cyclophosphamide therapy after progressing on paclitaxel and ovarian suppressor goserelin with aromatase inhibitor exemestane. The patient was comanaged by cardiology, who carefully monitored measures of cardiac function, including EKGs, serial echocardiograms, and profiling of lipids, troponin, and pro-BNP every 2 months. The patient was treated with the cardioprotective agent dexrazoxane, and changes in cardiac markers [e.g. decreases in ejection fraction (EF)] were immediately addressed by therapeutic intervention with the ACE inhibitor lisinopril and beta-blocker metoprolol. The patient had a complete response to doxorubicin therapy, with a cumulative dose of 1,350 mg/m2, which is significantly above the recommended limits, and to our knowledge, the highest dose reported in literature. Two and a half years after the last doxorubicin cycle, the patient is asymptomatic with no cardiotoxicity and an excellent quality of life. This case highlights the importance of careful monitoring and management of doxorubicin-mediated cardiotoxicity, and that higher cumulative doses of anthracyclines can be considered in patients with ongoing clinical benefit.

scholarly journals Comparative economic performance of traditional and modernised fishmeal units in Veraval, Gujarat

2017 ◽  
Vol 64 ◽  
Author(s):  
V. Chandrasekar ◽  
P. Jeyanthi ◽  
Nikitha Gopal
Keyword(s):  
Economic Performance ◽  
Agricultural Sector ◽  
Net Present Value ◽  
Fish Meal ◽  
Modern Method ◽  
Raw Material ◽  
Cost Ratio ◽  
Benefit Cost Ratio ◽  
Benefit Cost

Fish meal is an important feed ingredient produced from trash and low value fishes and is widely used in the poultry, aquafeed and agricultural sector. In addition to traditional sun dried product, modern fish meal is produced by modern fish meal plants. This paper presents a comparison of economic performance of fish meal units adopting the traditional and modern methods of fish meal production in Veraval, Gujarat. The study was conducted among 12 fish meal plants operating in Veraval. In the traditional method, the raw material is sourced from and nearby places within the state which is sun dried and then ground to produce fish meal. In modern fish meal units, through a mechanised production line, raw fish is steam-cooked, dried and finally ground to produce fish meal. Quality of the fish meal produced in the modernised units was found to be superior as compared to traditional fish meal. While sun dried fish meal fetches `20-30 kg-1, the fish meal produced in modern units is sold at `50-70 kg-1. Even though the initial investment and operational cost, which includes raw material, labour and other overheads is more in the modern method, the price realisation is almost double per unit of the product and the quality of the fish meal is also better than the traditionally produced one. The benefit cost ratio and net present value for modern method was also estimated to be higher.

scholarly journals Effect of Mother Plant Nutrition on Seed Quality of Wheat (Triticum aestivum.L) in Central Terai Region of Nepal

2017 ◽  
Vol 5 (4) ◽  
pp. 542-547
Author(s):  
Prakash Paneru ◽  
Birendra Kumar Bhattachan ◽  
Lal Prasad Amgain ◽  
Suman Dhakal ◽  
Bisheswar Prasad Yadav ◽  
...  
Keyword(s):  
Grain Yield ◽  
Crop Production ◽  
Seed Quality ◽  
Mother Plant ◽  
Cost Ratio ◽  
Net Income ◽  
Nitrogen And Phosphorus ◽  
Benefit Cost Ratio ◽  
Benefit Cost

Seed quality is the major concern for future crop production which largely depends on the nutrient we applied. To evaluate the effect of different doses of nitrogen and phosphorus on yield and seed quality of wheat an experiment was conducted during 2014/15 at agronomy research block of Agriculture and Forestry University. The experiment was designed on randomized complete block experiment with four levels of Nitrogen (0, 50, 100, and 150 kg N/ha) and Phosphorus (0, 25, 50, 75 kg P205/ha) Lab experiment was conducted to evaluate the germination and vigor test of the progeny seeds obtained from the mother plant. Highest grain yield (3.64t/ha) was associated with 100 kg N/ha which was statically similar with 150 kg N/ha, similarly highest grain yield (3.14t/ha) was associated with 75 kg P/ha which was at par with 50 kg P/ha and 25 kg P/ha. Highest germination percentage was associated with 150 kg N/ha (94.08) and 75 kg P/ha (93.66) Highest vigor was observed (36.5) at 100 kg N/ha which was at par with 150 kg N/ha whereas highest vigor was obtained at 50 kg P/ha (35.77) which was at par with 75 kg P/ha (35.71) Gross return, Net return and Benefit Cost ratio was highest at 100 kg N/ha which was at par with 150 kg N/ha. Similarly highest gross return (104.9 thousands) was observed at 75 kg P/ha, highest net income (54.81 thousands), and benefit cost ratio (2.105) was observed with 50 kg P/ha. Therefore for the better yield, good economic return and good seed quality application of nitrogenous fertilizers at 100 kg N/ha and phosphorus at 50 kg P/ha is useful under Chitwan condition.

The impact of telemedicine on the quality and satisfaction with the health care provided during the COVID-19 pandemic in the field of pediatrics with special reference to the surgical professions

2021 ◽  
Vol 93 (6) ◽  
pp. 53-60
Author(s):  
Marko Bašković
Keyword(s):  
New Technologies ◽  
Learning Ability ◽  
Cost Ratio ◽  
Benefit Cost Ratio ◽  
Surgical Services ◽  
Safe Technique ◽  
High Benefit ◽  
Benefit Cost ◽  
The Impact

The COVID-19 pandemic has forced healthcare systems around the world to adopt telemedicine at an unprecedented rate. Visits to telemedicine have increased to provide access and maintain continuity of care. Internet access has almost become a necessity, and new technologies allow for the easy flow of data from patient to doctor and vice versa. Doctors of all specialties were forced to adapt to the pandemic and emerging conditions. The provision of surgical services and the learning ability of surgeons are particularly disrupted, and the pediatric surgical community is not exempt. During the pandemic, telemedicine proved to be a viable and safe technique for providing health services. In an environment of a health system that is constantly facing a shortage of resources, effective telemedicine placement can come with a high benefit-cost ratio and quality of care, while ensuring patient satisfaction.

scholarly journals The ecology, productivity and economic of swiftlet (Aerodramus fuciphagus) farming in Kota Bangun, East Kalimantan, Indonesia

2020 ◽  
Vol 21 (7) ◽  
Author(s):  
Mursidah MURSIDAH ◽  
Abubakar M. Lahjie ◽  
MASJAYA MASJAYA ◽  
Yaya Rayadin ◽  
YOSEP RUSLIM
Keyword(s):  
Quantitative Analysis ◽  
Net Present Value ◽  
Global Market ◽  
Cost Ratio ◽  
Net Benefit ◽  
Benefit Cost Ratio ◽  
East Kalimantan ◽  
Benefit Cost ◽  
Aerodramus Fuciphagus

Abstract. Mursidah, Lahjie AM, Masjaya, Rayadin Y, Ruslim Y. 2020. The ecology, productivity and economic of swiftlet (Aerodramus fuciphagus) farming in Kota Bangun, East Kalimantan, Indonesia. Biodiversitas 21: 3117-3126. Swiftlet nest is a high-value non-timber forest product produced from the saliva of swiftlet birds. While the demands for this commodity continue to increase in global market, careless harvesting techniques have diminished the swiftlet population and the production of swiftlet nests, threatening its sustainability. One effort to solve this problem is by developing swiftlet farming which involves building swiftlet. This research aimed to analyze the ecology, productivity, and financial feasibility of swiftlet farming of different-sized swiftlet houses in Kota Bangun Subdistrict, East Kalimantan, Indonesia. This research used qualitative and quantitative analysis methods. Data were collected using purposive sampling to determine the location, sample of swiftlet houses, and interviews with respondents. Quantitative analysis on the financial performance of swiftlet farming was analyzed using the net Benefit-Cost Ratio (net B/C), Net Present Value (NPV), Internal Rate of Return (IRR) and Payback Period (PP) methods. The results showed that swiftlet nest production in Kota Bangun begins in the third year and ends between 27 and 45 years later, depending on the age and size of the house as well as the quality of the timber. The swiftlet house with a size of ​​512 m2 had the net B/C of 4.06, NPV of IDR 1,403.79 million, IRR of 30%, and PP of 5.44 years. The swiftlet house with a size of ​​1,600 m2 had the net B/C of 2.27, NPV of IDR 1,774.83 million, IRR of 24.09%, and PP of 9.4 years. Our study suggests that swiftlet farming is financially highly feasible, especially for the swiftlet house with a size of 512 m2.

scholarly journals Utilization Of Urine Waste To Produce Quality Cauliflower

2013 ◽  
Vol 12 ◽  
pp. 91-96
Author(s):  
A Khanal ◽  
SM Shakya ◽  
MD Sharma
Keyword(s):  
Block Design ◽  
Cost Ratio ◽  
Benefit Cost Ratio ◽  
Yield And Quality ◽  
Randomized Complete Block Design ◽  
Agriculture And Environment ◽  
Vegetative Characters ◽  
Quality Character ◽  
Benefit Cost

A field experiment was carried out at Jamune-1, Gunadi, Tanahun, Nepal on farmer’s field during September, 2009 to February, 2010 to test the efficacy of cattle urine from gutter alone and in combination with urea as a potential supplement to nitrogenous fertilizers in improving yield and quality of cauliflower cv. Kathmandu Local. The experiment was laid out in a randomized complete block design with eight treatments; 100 kg N ha-1 supplied by urea, 100 kg N ha-1 supplied by urine, 125 kg N ha-1 supplied by urine, 75 kg N ha-1 supplied by urine, 50 kg N ha-1 supplied by urine, 100 kg N ha-1 supplied by urea (75 kg) and urine (25 kg), 100 kg N ha-1 supplied by urea (50 kg) and urine (50 kg), 100 kg N ha-1 supplied by urea (25 kg) and urine (75 kg) having three replications. Application of 125 kg N ha-1 through urine significantly increased vegetative characters. Application of 100 kg N ha-1 through urine significantly increased yield and quality characters as compared to application of either higher or lower dose of urine. Fifty percent substitution of urea by urine produce better morphological, yield and quality character than other combination of urine and urea. The highest curd yield (20.08 t ha-1), the best result in sensory evaluation, and the highest benefit cost ratio (5.84) were observed by application of 100 kg N ha-1 through urine. The Journal of Agriculture and Environment Vol:12, Jun.2011, Page 91-96 DOI: http://dx.doi.org/10.3126/aej.v12i0.7568

Tidal Power Projects in the Bay of Fundy

1983 ◽  
Vol 2 (1) ◽  
pp. 81-90 ◽  
Author(s):  
G. C. Baker
Keyword(s):  
Tidal Energy ◽  
Energy Market ◽  
Cost Ratio ◽  
Bay Of Fundy ◽  
Tidal Power ◽  
Technical Problems ◽  
Capital Costs ◽  
Benefit Cost Ratio ◽  
Benefit Cost

The geography of the Bay of Fundy, where the tide is probably the highest in the world, is conducive to the concentration of tidal energy, and has therefore been the site of many attempts at harnessing its power. Capital costs, and not technical problems, have been the major source of failure, and are still the overriding constraint on development. After 1973, Canadian Government agencies re-examined the case for development, and great efforts have gone into researching the resource. The benefit/cost ratio in 1981 was of the order of 2.5 or 3.0 to 1, but the fluctuations of the energy market have put off any resolve to develop a large Fundy project, at least until long-term contracts for its power have been secured.

scholarly journals Influence of mulching, liming and farm yard manures on production potential, economics and quality of maize (Zea mays L.) under rainfed condition of Eastern Himalaya

2018 ◽  
Vol 44 (3) ◽  
pp. 391-398 ◽  
Author(s):  
Rakesh Kumar
Keyword(s):  
Grain Yield ◽  
Quality Attributes ◽  
Eastern Himalaya ◽  
Cost Ratio ◽  
Yield Attributes ◽  
Net Return ◽  
Benefit Cost Ratio ◽  
Stover Yield ◽  
Benefit Cost

A field experiment was conducted to study the effect of mulching, liming and farm yard manures on productivity and quality of maize on a sandy loam soil at Agricultural Research Farm of ICAR RC NEH Region Nagaland Centre, Jharnapani, Medziphema during two consecutive rabi seasons of 2010-12 under the rainfed conditions of Eastern Himalaya. Treatment comprised of two mulches (without mulch and straw mulch) in main plot, four levels of lime (control, 0.2, 0.4 and 0.6 t/ha) in sub plot and three levels of farm yard manures (4, 8 and 12 t/ha) in sub-sub plot and replicated thrice in split-split plot design. The significant improvement in yield attributes (cob length, number of rows/cob, number of grain/row, number of grain/cob and 1000-grain weight), yields (grain, stover and biological), economics (gross, net returns and benefit: cost ratio) and quality attributes (carbohydrate, starch and sugar) of maize were recorded in straw mulched plot over no mulch in both the years. The straw mulching recorded 15.9 and 16.5% increase in grain yield and 20.4 and 22.2% in stover yield over no mulch. Application of 0.6 t lime/ha in furrow recorded the significantly higher yield attributes, grain yield (3.85 and 3.97 t/ha), stover yield (4.16 and 4.33 t/ha), gross return (41.87 and 43.25 ×103/ha), net return (28.45 and 29.83 ×103/ha) and benefit: cost ratio (1.55 and 1.63) and quality attributes over rest of the levels, respectively. Application of farm yard manures @ 12 t/ha noted significantly higher yield attributes yield and quality attributes of maize over rest of the treatments. Similar effect of these treatments was observed on gross return of Rs. 40.75 and 41.78 × 103/ ha, net return of Rs. 27.5 and Rs. 28.53 × 103/ha and benefit : cost ratio of 1.52 and 1.57 in both the years, respectively.

Comparative Effectiveness Of Seed Treating And Foliar Insecticides Against Sucking Pests Of Cotton And Impact On Their Natural Enemies

2013 ◽  
Vol 38 (1) ◽  
pp. 61-70 ◽  
Author(s):  
SMA Hossain ◽  
MA Baque ◽  
MR Amin
Keyword(s):  
Natural Enemies ◽  
Untreated Control ◽  
Seed Treatment ◽  
Foliar Spray ◽  
Cost Ratio ◽  
Research Station ◽  
Benefit Cost Ratio ◽  
Benefit Cost ◽  
Thrips Population ◽  
Cotton Cultivar

The Imidacloprid insecticide, Gaucho 70 WS at 1.5, 2.5, 3.5, 4.5 and 5.5 g/kg seed was used as seed treatment and monocrotophos 40 WSC at 1120 ml/ha was applied as foliar spray on CB9 cotton cultivar to suppress aphid, whitefly and thrips, and impact on their natural enemies during 2008-2011 at the Regional Cotton Research Station, Dinajpur, Bangladesh. The activity of natural enemies, such as ladybird beetle, lacewing, syrphid, and spider population on the sucking pests attacking cotton cultivar CB9 and yield of cotton were recorded. Imidacloprid significantly reduced aphid, whitefly, and thrips population on cotton crops compared to untreated control or foliar spray of monocrotophos 40 WSC at 1120 ml/ha. Ladybird beetles, lacewings, syrphids, and spiders were abundant in the field but their population decreased in the treated plots compared to untreated control. The CB9 cotton cultivar produced significantly higher yield (1.73 t/ha) with a benefit cost ratio 12.47 when seeds were treated with Imidacloprid at 5.5 g/kg fuzzy seed. This study indicated that Imidacloprid (Gaucho 70 WS) used as a seed treatment may be suggested to the cotton growers for controlling sucking pests. Bangladesh J. Agril. Res. 38(1): 61-70, March 2013 DOI: http://dx.doi.org/10.3329/bjar.v38i1.15190

EVALUASI TERHADAP PENGELOLAAN SAMPAH DALAM MENINGKATKAN PELAYANAN ASET DI KOTA PEMATANGSIANTAR

2017 ◽  
Vol 13 (3) ◽  
pp. 240
Author(s):  
Novdin M Sianturi
Keyword(s):  
Net Present Value ◽  
Payback Period ◽  
Rate Of Return ◽  
Cost Ratio ◽  
Internal Rate Of Return ◽  
Present Value ◽  
Benefit Cost Ratio ◽  
Internal Rate ◽  
Benefit Cost

Abstrak: Pengelolaan sampah di Kota Pematangsiantar masih bertumpu pada pendekatan akhir (kumpul-angkut-buang), dengan tingkat pelayanan yang rendah, sehingga untuk meningkatkan pelayanan sampah, perlu dilakukan pemilahan di tempat penampungan sementara (TPS). Penelitian ini bertujuan untuk mengkaji sistem pengelolaan sampah dengan melakukan pemilihan di TPS dapat meningkatkan pelayanan aset persampahan sampai tahun  2015 secara teknis operasional dan dari aspek keuangan. Analisa teknis operasional aset pengelolaan sampah mulai dari pewadahan, pengumpulan dan pengangkutan sedangkan analisa keuangan dan analisa kelayakan menggunakan Net Present Value, Internal Rate of Return, Benefit/Cost Ratio, dan Payback Period. Dari hasil analisa tersebut diperoleh suatu sistem pengelolaan sampah dengan pemilihan di TPS berdasarkan zona pelayanan dengan skala prioritas secara bertahap daritahun 2013-2017, dapat meningkatkan cakupan pelayanan sampah eksisting rata-rata 6,69 %, cakupan pelayanan TPS eksisting rata-rata 8,29 %, dan cakupan pelayanan truk pengangkut sampah eksisting rata-rata 12,03 %. Investasinya layak, diperoleh Net Cashflow pada tahun 2020 sebesar Rp 1.720.242.284,-, NPV suku bunga 15 % bernilai positif, IRR > MARR 15 %,  B/C Ratio > 1, dan PP 4,7 tahun, lebih pendek dari periode investasi 10 tahun. Dari Metode penelitian ini maka pengumpulan data, observasi lapangan dan pengukuran contoh timbulan sampah dengan sampel 4 TPS perumahan yang terlayani pengangkutan.

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