scholarly journals Personalized Cancer Care: Risk Prediction, Early Diagnosis, Progression, and Therapy

2016 ◽  
Vol 1 (3) ◽  
pp. 1-9
Author(s):  
Kurt S. Zänker ◽  
Anne-Lise Borresen-Dale ◽  
Hans-Peter Huber
Keyword(s):  
Risk Prediction ◽  
Cancer Care ◽  
Tumor Therapy ◽  
Genomic Medicine ◽  
Tumor Evolution ◽  
Genetic Profiling ◽  
Intracellular Proteins ◽  
Precise Diagnosis ◽  
Methods Analytical ◽  
Personalized Cancer

At the annual prestigious International Symposium of the Fritz-Bender Foundation, Munich, 18-20 May, 2016, researchers, clinicians, and students discussed the state of the art and future perspectives of genomic medicine in cancer. Genomic medicine (also known as precision medicine/oncology) should help clinicians to provide a more precise diagnosis and therapy in oncology for individual patients. The meeting focused on next-generation sequencing methods, analytical computational analysis of big data, and data mining on the way to translational and evidence-based medicine. The meeting covered the social and ethical impact of genomic medicine as well as news and views on antibody targeting of intracellular proteins, on the architecture of intracellular proteins and their impact on carcinogenesis, and on the adaptation of tumor therapy in due consideration of tumor evolution. Subheadings like “Genetic Profiling of Patients and Risk Prediction,” “Molecular Profiling of Tumors and Metastases,” “Tumor-Host Microenvironment Interaction and Metabolism,” and “Targeted Therapy” were subsumed under the main heading of “Personalized Cancer Care.”

scholarly journals Building a Personalized Medicine Infrastructure at a Major Cancer Center

2013 ◽  
Vol 31 (15) ◽  
pp. 1849-1857 ◽  
Author(s):  
Funda Meric-Bernstam ◽  
Carol Farhangfar ◽  
John Mendelsohn ◽  
Gordon B. Mills
Keyword(s):  
Cancer Therapy ◽  
Cancer Care ◽  
Cancer Biology ◽  
Genomic Medicine ◽  
Cancer Center ◽  
Molecular Therapeutics ◽  
Number Of Patients ◽  
Wide Range ◽  
Personalized Cancer Therapy ◽  
Personalized Cancer

Our understanding of cancer biology is rapidly increasing, as is the availability and affordability of high throughput technologies for comprehensive molecular characterization of tumors and the individual's own genetic makeup. Thus, the time is right to implement personalized molecular medicine for all patients with cancer. Personalized approaches span the full cancer care spectrum from risk stratification to prevention, screening, therapy, and survivorship programs. Several molecular therapeutics have entered clinical trials creating a huge opportunity to couple genomic markers with this emerging drug tool kit. The number of patients managed in major cancer centers creates a challenge to the implementation of genomic technologies required to successfully deliver on the promise of personalized cancer care. This requires a major investment in infrastructure to facilitate rapid deployment of multiplex, cost-effective, and tissue-sparing assays relevant across multiple tumor lineages in the Clinical Laboratory Improvement Amendments (CLIA) environment. Efforts must be made to ensure that assays are accessible to patients most likely to be enrolled onto molecular-marker–driven trials and that the tests are billable and payable, which will make them accessible to a wide range of patients. As the number of patients and aberrations increase, it will become critical to provide decision support for genomic medicine. Institutional commitment is needed to optimize accessibility and quality of research biopsies and to facilitate novel personalized cancer therapy trials. This article will focus on the challenges and opportunities that accompany the building of infrastructure for personalized cancer therapy.

scholarly journals Microsimulation Model For The Assessment Of Personalized Cancer Care: The Mapcca Model Framework

2014 ◽  
Vol 17 (7) ◽  
pp. A562
Author(s):  
E. Van der Meijde ◽  
A.J. van den Eertwegh ◽  
R.J. Fijneman ◽  
G.A. Meijer ◽  
S.C. Linn ◽  
...  
Keyword(s):  
Cancer Care ◽  
Microsimulation Model ◽  
Model Framework ◽  
Personalized Cancer

Genomic medicine and risk prediction across the disease spectrum

2015 ◽  
Vol 52 (3) ◽  
pp. 120-137 ◽  
Author(s):  
Maritha J. Kotze ◽  
Hilmar K. Lückhoff ◽  
Armand V. Peeters ◽  
Karin Baatjes ◽  
Mardelle Schoeman ◽  
...  
Keyword(s):  
Risk Prediction ◽  
Genomic Medicine ◽  
Disease Spectrum

Professionalism in Global, Personalized Cancer Care: Restoring Authenticity and Integrity

2013 ◽  
pp. 152-156
Author(s):  
Antonella Surbone
Keyword(s):  
Moral Education ◽  
Cancer Care ◽  
Conflicts Of Interest ◽  
Global Scale ◽  
Cancer Therapies ◽  
Global Issues ◽  
Body Of Knowledge ◽  
New Cancer Therapies ◽  
Correct Application ◽  
Personalized Cancer

Personalized medicine is revolutionizing cancer care and creating new expectations among oncologists and patients. At present the benefit is still marginal, however, and must be understood as incremental. In addition, cultural and resource disparities limit the sustainability of new cancer therapies on a global scale. Adequate instruments are needed to enable our exercise of sound and honest judgment in distinguishing breakthrough treatments from those that yield only marginal or doubtful improvements, and to develop strategies for formulation and correct application of balanced guidelines for sustainable cancer care. Professionalism requires that the acquisition of knowledge and skills go hand in hand with moral education in the intellectual virtues of humility, perseverance, adaptability, communicativeness, and commitment to resist self-deception or conflicts of interest. Hidden curricula undermine the moral values of medicine: these must be understood and uncovered. We should possess a special body of knowledge, skills, and values that allow us to change our practices when appropriate and to be stewards of society's limited resources through proper communication with our patients and families. In the era of personalized oncology and global issues of sustainability, professional authenticity and integrity in cancer clinical practice are key to bridging the gaps between true and false expectations of patients and the public.

scholarly journals Toward a future of personalized cancer care

Cancer ◽  
2008 ◽  
Vol 113 (S7) ◽  
pp. 1724-1727 ◽  
Author(s):  
Michael O. Leavitt ◽  
Gregory J. Downing
Keyword(s):  
Cancer Care ◽  
Personalized Cancer

Intracellular Doppler Imaging Clinical Trials in Personalized Cancer Care

2018 ◽  
Author(s):  
David D. Nolte ◽  
Zhe Li ◽  
Honggu Choi ◽  
Michael Childress ◽  
John Turek ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cancer Care ◽  
Doppler Imaging ◽  
Personalized Cancer
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