scholarly journals Viability of Primary Human Pigment Epithelium Cells and Muller-Glia Cells after Intravitreal Ziv-Aflibercept and Aflibercept

2016 ◽  
Vol 236 (4) ◽  
pp. 223-227 ◽  
Author(s):  
Gabriel Costa de Andrade ◽  
Christian Wertheimer ◽  
Kirsten Eibl ◽  
Armin Wolf ◽  
Anselm Kampik ◽  
...  
Keyword(s):  
Pigment Epithelium ◽  
Muller Glia ◽  
Müller Glia ◽  
Glia Cells ◽  
Epithelium Cells

Glutamate Receptor Stimulation Up-Regulates Glutamate Uptake in Human Müller Glia Cells

2016 ◽  
Vol 41 (7) ◽  
pp. 1797-1805 ◽  
Author(s):  
Ana María López-Colomé ◽  
Edith López ◽  
Orquidia G. Mendez-Flores ◽  
Arturo Ortega
Keyword(s):  
Glutamate Receptor ◽  
Glutamate Uptake ◽  
Muller Glia ◽  
Müller Glia ◽  
Receptor Stimulation ◽  
Glia Cells

scholarly journals Adult Human Müller Glia Cells Are a Highly Efficient Source of Rod Photoreceptors

Stem Cells ◽  
2011 ◽  
Vol 29 (2) ◽  
pp. 344-356 ◽  
Author(s):  
Serena G. Giannelli ◽  
Gian Carlo Demontis ◽  
Grazia Pertile ◽  
Paolo Rama ◽  
Vania Broccoli
Keyword(s):  
Muller Glia ◽  
Müller Glia ◽  
Rod Photoreceptors ◽  
Glia Cells ◽  
Adult Human ◽  
Highly Efficient

scholarly journals Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Müller glia cells

2006 ◽  
Vol 15 (18) ◽  
pp. 2659-2672 ◽  
Author(s):  
Agnes G.S.H. van Rossum ◽  
Wendy M. Aartsen ◽  
Jan Meuleman ◽  
Jan Klooster ◽  
Anna Malysheva ◽  
...  
Keyword(s):  
Muller Glia ◽  
Müller Glia ◽  
Glia Cells ◽  
Subapical Region

scholarly journals Clinically visible progression indicators in age-related macular degeneration are transdifferentiated retinal pigment epithelium

2021 ◽  
Author(s):  
Dongfeng Cao ◽  
Belinda Leong ◽  
Jeffrey D. Messinger ◽  
Deepayan Kar ◽  
Thomas Ach ◽  
...  
Keyword(s):  
Retinal Pigment Epithelium ◽  
Macular Degeneration ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Risk Indicators ◽  
Muller Glia ◽  
Müller Glia ◽  
Age Related ◽  
Oct Imaging

AbstractAge-related macular degeneration (AMD) is a common sight-threatening disease of older adults and treatment options are needed. Abnormalities of retinal pigment epithelium (RPE), supporting cells to photoreceptors and capillaries, are a hallmark. Clinical optical coherence tomography (OCT) imaging reveals hyperreflective foci (HRF) that confer risk for end-stage disease and are attributed to ectopic out-of-layer RPE. Using longitudinal OCT imaging of AMD patients, we demonstrate that the trajectory of one HRF form, RPE plume, parallels the retinal Henle fiber layer. Histology shows fully pigmented cells approaching and contacting retinal capillaries with RPE organelles dispersing along Müller glia columns. We used immunohistochemistry and a system of morphologic phenotypes to assess RPE functional repertoire in AMD. RPE corresponding to HRF loses immunoreactivity for retinoid processing proteins RPE65 and CRALBP, and gains immunoreactivity for immune cell markers CD68 and CD163. Müller glia retain CRALBP immunoreactivity. Gain- and loss-of-function for RPE starts with individual in-layer cells and extends to all abnormal phenotypes. Down-regulated RPE retinoid handling may contribute to slowed rod vision while Müller glia sustain cone vision. Ectopic RPE corresponding to HRF are emblematic of widespread transdifferentiation, motivating treatments targeting AMD pathology earlier than the initiation of atrophy. Data can propel new biomarkers and therapeutic strategies for AMD.One Sentence SummaryIn age-related macular degeneration retinal pigment epithelial cells transdifferentiate and migrate into the retina where they are clinically visible progression risk indicators.

scholarly journals Antiserum to lens antigens immunostains Muller glia cells in the neural retina.

1985 ◽  
Vol 82 (16) ◽  
pp. 5570-5573 ◽  
Author(s):  
A. A. Moscona ◽  
L. Fox ◽  
J. Smith ◽  
L. Degenstein
Keyword(s):  
Neural Retina ◽  
Muller Glia ◽  
Müller Glia ◽  
Glia Cells

Pax6-positive müller glia cells express cell cycle markers but do not proliferate after photoreceptor injury in the mouse retina

Glia ◽  
2011 ◽  
Vol 59 (7) ◽  
pp. 1033-1046 ◽  
Author(s):  
Sandrine Joly ◽  
Vincent Pernet ◽  
Marijana Samardzija ◽  
Christian Grimm
Keyword(s):  
Cell Cycle ◽  
Mouse Retina ◽  
Muller Glia ◽  
Müller Glia ◽  
Glia Cells ◽  
Express Cell
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