scholarly journals Adult Human Müller Glia Cells Are a Highly Efficient Source of Rod Photoreceptors

Stem Cells ◽  
2011 ◽  
Vol 29 (2) ◽  
pp. 344-356 ◽  
Author(s):  
Serena G. Giannelli ◽  
Gian Carlo Demontis ◽  
Grazia Pertile ◽  
Paolo Rama ◽  
Vania Broccoli
2016 ◽  
Vol 41 (7) ◽  
pp. 1797-1805 ◽  
Author(s):  
Ana María López-Colomé ◽  
Edith López ◽  
Orquidia G. Mendez-Flores ◽  
Arturo Ortega

2016 ◽  
Vol 236 (4) ◽  
pp. 223-227 ◽  
Author(s):  
Gabriel Costa de Andrade ◽  
Christian Wertheimer ◽  
Kirsten Eibl ◽  
Armin Wolf ◽  
Anselm Kampik ◽  
...  

2006 ◽  
Vol 15 (18) ◽  
pp. 2659-2672 ◽  
Author(s):  
Agnes G.S.H. van Rossum ◽  
Wendy M. Aartsen ◽  
Jan Meuleman ◽  
Jan Klooster ◽  
Anna Malysheva ◽  
...  

2019 ◽  
Vol 71 (4) ◽  
pp. 711-719
Author(s):  
Sanja Ivkovic ◽  
Irena Jovanovic-Macura ◽  
Tijana Antonijevic ◽  
Selma Kanazir ◽  
Domingos Henrique

Epidermal growth factor (EGF) signaling has been implicated in the regulation of the differentiation and proliferation of retinal progenitors. We assessed how different levels of EGF signaling, achieved either by increasing receptor expression or via addition of the exogenous ligand, or an increase in both, can affect the differentiation of progenitors in the first week of postnatal retinal development in the model system of retinal explants (REs). Proliferating progenitor cells in REs were infected with either the control CLV3/ESR-related peptide family (CLE)-green fluorescent protein (GFP)- or with EGF receptor (EGFR)-GFP-expressing retrovirus, and grown in the control medium or in the presence of exogenous EGF (10 ng/mL). The differentiation of infected cells into Muller glia (Sox9+), rod photoreceptors (rhodopsin+) and horizontal cells (calbindin+) was analyzed. In all the examined conditions, infected cells differentiated into Muller glia and rod photoreceptors that normally develop postnatally. Horizontal cells finished their development during the embryonic stages and progenitors infected with control-GFP virus did not differentiate into GFP+/calbindin- in either control or EGFsupplemented medium, however, cells infected with EGFR-GFP differentiated into horizontal cells (GFP+/calbindin+) in both culture conditions. These results imply that altering the levels of EGFR and/or the amount of the EGF ligand can overcome progenitor competence restriction.


1985 ◽  
Vol 82 (16) ◽  
pp. 5570-5573 ◽  
Author(s):  
A. A. Moscona ◽  
L. Fox ◽  
J. Smith ◽  
L. Degenstein

Glia ◽  
2011 ◽  
Vol 59 (7) ◽  
pp. 1033-1046 ◽  
Author(s):  
Sandrine Joly ◽  
Vincent Pernet ◽  
Marijana Samardzija ◽  
Christian Grimm

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