A Difference in the Incidences of Hypersensitivity Reactions to Original and Generic Taxanes

Chemotherapy ◽  
2016 ◽  
Vol 62 (2) ◽  
pp. 134-139 ◽  
Author(s):  
Tanchanok Ratanajarusiri ◽  
Virote Sriuranpong ◽  
Piyada Sitthideatphaiboon ◽  
Nattaya Poovoravan ◽  
Chanida Vinayanuwat ◽  
...  
Keyword(s):  
Hypersensitivity Reaction ◽  
Prospective Study ◽  
Active Surveillance ◽  
Generic Drugs ◽  
Hypersensitivity Reactions ◽  
Paclitaxel Group ◽  
Life Threatening ◽  
Grade 3 ◽  
A Prospective Study ◽  
Docetaxel Group

Purpose: To compare incidences of hypersensitivity reaction (HSR) between original and generic taxanes including paclitaxel and docetaxel. Methods: We conducted a prospective study enrolling all patients receiving taxanes at King Chulalongkorn Memorial Hospital. Taxanes were infused accordingly to the step-wise rate escalation protocol at this hospital. Active surveillance for HSRs was performed. During the study period, there was only 1 generic brand used for each taxane. We primarily compared the incidences of HSR between original and generic drugs for each taxane. Results: During the period from January 1 to December 31, 2013, a total of 258 consecutive patients receiving taxanes were enrolled; 128 received paclitaxel, i.e. 65 and 63 in the original (Taxol) and generic arms, respectively, and 130 received docetaxel, i.e. 66 and 64 in the original (Taxotere) and generic arms, respectively. Premedication, including antihistamines and dexamethasone, was administered to all patients 30 min before taxane infusion. There were 26 (10.0%) HSR events including 24 grade 2 and 2 grade 3 HSRs. In the paclitaxel group, there were 9 (13.8%) and 7 (11.1%) HSRs in the original and generic arms, respectively (p = 0.791). In the docetaxel group, there were 9 (13.6%) and 1 (1.6%) HSRs in the original and generic arms, respectively (p = 0.017). No life-threatening symptoms or permanent discontinuation of taxanes occurred. Conclusions: In this prospective study, the incidences of HSR were similar with generic and original paclitaxel but significantly different with generic and original docetaxel.

scholarly journals Clinical assessment of detection of ventricular extrasystoly in patients without structural changes of heart: a prospective study

2017 ◽  
Vol 8 (4) ◽  
pp. 64-72
Author(s):  
Anastasia V. Koziy ◽  
Alexander I. Olesin ◽  
Vadim A. Litvinenko ◽  
Irina V. Konstantinova
Keyword(s):  
Prospective Study ◽  
Clinical Assessment ◽  
Structural Changes ◽  
Prognostic Significance ◽  
City Hospital ◽  
Heart Rate Turbulence ◽  
Life Threatening ◽  
Highly Correlated ◽  
A Prospective Study

Aim. The aim of the study was a clinical assessment of the integrated determination of predictors of life-threatening ventricular arrhythmias (LVA) in patients with ventricular extrasystole (VE) without structural changes in the heart to predict the development of cardiovascular disease in a prospective study. Material and methods. From 1997 to 2014 199 patients with neurocirculatory dystonia (NCD), complicated with VE II-V class EE at the age of 18-35 years (mean 27.3-2.6 years) were observed in District Military Clinical Hospital of the Ministry of Defense of the Russian Federation, City Hospital named after St. Martyr Elizabeth. All patients, in addition to a general clinical examination, determined late potentials of the ventricles (LPV), QT interval variability (QTd), heart rate turbulence (HRT), and also indicators reflecting the possible mechanism of VE development. Results. The results of the study showed that in patients with NCD complicated by VE, the detection of indicators reflecting the presence of VE caused by the mechanisms of early post-depolarization and re-entry is a predictor of the development of coronary heart disease (CHD) and hypertension (HB). The positive prognostic significance of the indicators showing the presence of VE with these development mechanisms for the development of CHD and HB averaged 74% and 44% respectively, and with the appointment of сlass III drugs for elimination of VE and (or) development of unstable ventricular tachycardia, the risk of developing CHD increased to an average of 93%. Identification of NDC patients with indicators reflecting the presence of VE due to delayed post-depolarization is a predictor of the development of gastrointestinal tract (GT) diseases with positive prognostic significance, averaging 61%. Positive prognostic significance with respect to the development of CHD, HB, GT diseases for the detected LPV, QTd > 80 ms, pathological values of HRT VE did not exceed 30%. Indicators and predictors, which characterize the mechanism of development of VE and the risk of LVA occurrence in patients with NCD complicated by VE, were highly correlated (r > 0.50) with risk factors for cardiovascular and gastrointestinal system diseases.

Life-threatening adverse drug reactions at admission to medical intensive care: a prospective study in a teaching hospital

2007 ◽  
Vol 33 (12) ◽  
pp. 2150-2157 ◽  
Author(s):  
Marieke Grenouillet-Delacre ◽  
Hélène Verdoux ◽  
Nicholas Moore ◽  
Françoise Haramburu ◽  
Ghada Miremont-Salamé ◽  
...  
Keyword(s):  
Intensive Care ◽  
Prospective Study ◽  
Adverse Drug Reactions ◽  
Teaching Hospital ◽  
Drug Reactions ◽  
Life Threatening ◽  
Medical Intensive Care ◽  
A Prospective Study

A prospective study of costs associated to the evaluation of non‐steroidal anti‐inflammatory hypersensitivity reactions

Allergy ◽  
2020 ◽  
Vol 75 (6) ◽  
pp. 1495-1497 ◽  
Author(s):  
Miriam Sobrino‐García ◽  
Francisco J. Muñoz‐Bellido ◽  
Esther Moreno ◽  
Eva Macías ◽  
María‐Teresa Gracia‐Bara ◽  
...  
Keyword(s):  
Prospective Study ◽  
Hypersensitivity Reactions ◽  
Anti Inflammatory ◽  
A Prospective Study

Life-Threatening Malaria in African Children a Prospective Study in a Mesoendemic Urban Setting

2008 ◽  
Vol PAP ◽  
Author(s):  
Stéphane Ranque ◽  
Belco Poudiougou ◽  
Abdoulaye Traoré ◽  
Modibo Keita ◽  
Aboubacar A. Oumar ◽  
...  
Keyword(s):  
Prospective Study ◽  
Urban Setting ◽  
African Children ◽  
Life Threatening ◽  
A Prospective Study

scholarly journals A Prospective Study to Evaluate the Effect of Paclitaxel on Cardiac Ejection Fraction

Breast Care ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. 255-259 ◽  
Author(s):  
Mohammed Osman ◽  
Mohammad Elkady
Keyword(s):  
High Risk ◽  
Ejection Fraction ◽  
Prospective Study ◽  
Performance Status ◽  
Primary Objective ◽  
Cardiac Ejection Fraction ◽  
Grade 3 ◽  
A Prospective Study

Background: The primary objective of the study was to evaluate the long-term changes in ejection fraction (EF) associated with paclitaxel infusion. Methods: 50 patients were enrolled in this prospective study between 2011 and 2015. The study design included frequent follow-up visits to the clinic, EF evaluation at baseline, and regular EF assessment by echocardiography for 30 months after treatment. Results: The median baseline EF was 60% (95% confidence interval (CI) 50-80%). At 30 months, the median EF was 48% (95% CI 40-60%; p = 0.03). During the 30-month follow-up, 10 (20%) patients developed grade 1 and 2 cardiotoxicities; none developed grade 3 or 4 cardiotoxicities. Furthermore, paclitaxel cardiotoxicity increased among patients with high-risk features including associated diabetes mellitus, hypertension, prior radiotherapy to the chest wall, performance status of 2, and age > 60 years. Conclusion: Paclitaxel has cardiotoxic effects. Careful monitoring of cardiac function during and after paclitaxel infusion is required in patients with high-risk features.

scholarly journals Epistaxis among children in Usmanu Danfodiyo University Teaching Hospital Sokoto Nigeria

2020 ◽  
Vol 1 (2) ◽  
Author(s):  
Foluso M. Adeyeye ◽  
Kufre Iseh ◽  
Stanley B. Amutta ◽  
Mohammed Abdullahi ◽  
Daniel Aliyu
Keyword(s):  
Prospective Study ◽  
Teaching Hospital ◽  
University Teaching ◽  
Life Threatening ◽  
A Prospective Study ◽  
Clinical Conditions

Background: Epistaxis is a life-threatening otorhinolaryngological emergency and presents as a symptom of varied clinical conditions. The study was designed to determine the frequency and forms of epistaxis among children in Usmanu Danfodiyo University Teaching Hospital (UDUTH), Sokoto, Nigeria. Materials and Methods: It was a prospective study of children ≤12 years with epistaxis presenting to UDUTH, Sokoto from January to December 2017. Information on age, gender, causes, nature, and laterality of epistaxis was collected and analyzed. Results: Of 1078 children who presented with otorhinolaryngological complaints during the study period, 39 (3.6 %) had epistaxis, with majority 14

Sign in / Sign up

Export Citation Format

Share Document