A prospective study of costs associated to the evaluation of non‐steroidal anti‐inflammatory hypersensitivity reactions

Allergy ◽  
2020 ◽  
Vol 75 (6) ◽  
pp. 1495-1497 ◽  
Author(s):  
Miriam Sobrino‐García ◽  
Francisco J. Muñoz‐Bellido ◽  
Esther Moreno ◽  
Eva Macías ◽  
María‐Teresa Gracia‐Bara ◽  
...  
Keyword(s):  
Prospective Study ◽  
Hypersensitivity Reactions ◽  
Anti Inflammatory ◽  
A Prospective Study

A Difference in the Incidences of Hypersensitivity Reactions to Original and Generic Taxanes

Chemotherapy ◽  
2016 ◽  
Vol 62 (2) ◽  
pp. 134-139 ◽  
Author(s):  
Tanchanok Ratanajarusiri ◽  
Virote Sriuranpong ◽  
Piyada Sitthideatphaiboon ◽  
Nattaya Poovoravan ◽  
Chanida Vinayanuwat ◽  
...  
Keyword(s):  
Hypersensitivity Reaction ◽  
Prospective Study ◽  
Active Surveillance ◽  
Generic Drugs ◽  
Hypersensitivity Reactions ◽  
Paclitaxel Group ◽  
Life Threatening ◽  
Grade 3 ◽  
A Prospective Study ◽  
Docetaxel Group

Purpose: To compare incidences of hypersensitivity reaction (HSR) between original and generic taxanes including paclitaxel and docetaxel. Methods: We conducted a prospective study enrolling all patients receiving taxanes at King Chulalongkorn Memorial Hospital. Taxanes were infused accordingly to the step-wise rate escalation protocol at this hospital. Active surveillance for HSRs was performed. During the study period, there was only 1 generic brand used for each taxane. We primarily compared the incidences of HSR between original and generic drugs for each taxane. Results: During the period from January 1 to December 31, 2013, a total of 258 consecutive patients receiving taxanes were enrolled; 128 received paclitaxel, i.e. 65 and 63 in the original (Taxol) and generic arms, respectively, and 130 received docetaxel, i.e. 66 and 64 in the original (Taxotere) and generic arms, respectively. Premedication, including antihistamines and dexamethasone, was administered to all patients 30 min before taxane infusion. There were 26 (10.0%) HSR events including 24 grade 2 and 2 grade 3 HSRs. In the paclitaxel group, there were 9 (13.8%) and 7 (11.1%) HSRs in the original and generic arms, respectively (p = 0.791). In the docetaxel group, there were 9 (13.6%) and 1 (1.6%) HSRs in the original and generic arms, respectively (p = 0.017). No life-threatening symptoms or permanent discontinuation of taxanes occurred. Conclusions: In this prospective study, the incidences of HSR were similar with generic and original paclitaxel but significantly different with generic and original docetaxel.

Local and systemic pro-inflammatory and anti-inflammatory cytokine patterns in patients with chronic subdural hematoma: a prospective study

2012 ◽  
Vol 61 (8) ◽  
pp. 845-852 ◽  
Author(s):  
Milo Stanisic ◽  
Ansgar Oddne Aasen ◽  
Are Hugo Pripp ◽  
Karl-Fredrik Lindegaard ◽  
Jon Ramm-Pettersen ◽  
...  
Keyword(s):  
Prospective Study ◽  
Subdural Hematoma ◽  
Inflammatory Cytokine ◽  
Chronic Subdural Hematoma ◽  
Anti Inflammatory ◽  
A Prospective Study ◽  
Anti Inflammatory Cytokine

Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study

2005 ◽  
Vol 6 (12) ◽  
pp. 945-952 ◽  
Author(s):  
Thomas L Vaughan ◽  
Linda M Dong ◽  
Patricia L Blount ◽  
Kamran Ayub ◽  
Robert D Odze ◽  
...  
Keyword(s):  
Prospective Study ◽  
Barrett’S Oesophagus ◽  
Neoplastic Progression ◽  
Barrett's Oesophagus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
A Prospective Study
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