Serum Uric Acid Exhibits Inverse Relationship with Estimated Glomerular Filtration Rate

Nephron ◽  
2016 ◽  
Vol 134 (4) ◽  
pp. 231-237 ◽  
Author(s):  
Abhilash Koratala ◽  
Girish Singhania ◽  
Kawther F. Alquadan ◽  
Michiko Shimada ◽  
Richard J. Johnson ◽  
...  
Keyword(s):  
Uric Acid ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Serum Uric Acid ◽  
Filtration Rate ◽  
Inverse Relationship ◽  
Estimated Glomerular Filtration Rate

scholarly journals Enhancing effect of glycine and tryptophan mixture on estimated glomerular filtration rate in healthy participants: A randomized, double-blind, placebo-controlled parallel study

2021 ◽  
Vol 11 (1) ◽  
pp. 24
Author(s):  
Shunji Oshima ◽  
Sachie Shiiya ◽  
Yasunori Nakamura
Keyword(s):  
Uric Acid ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Serum Uric Acid ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Parallel Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Healthy Participants

Background: The mixture of glycine and tryptophan exhibited serum uric acid-lowering effects in our previous clinical trial.Objective: Using a randomized, double-blind, placebo-controlled, and parallel study design, this current study aimed to examine whether this mixture enhanced the estimated glomerular filtration rate (eGFR) as an indicator of renal function in healthy individuals.Methods: Healthy Japanese adult males and females ingested a powder mixture containing 3.0 g of glycine and 0.2 g of tryptophan or a placebo powder once daily at bedtime for 8 weeks.Results: After 8 weeks of continual ingestion, the combined glycine and tryptophan supplementation significantly enhanced eGFR. It also decreased serum uric acid levels, consistent with our previous reports. Meanwhile, the continual ingestion of the mixture had no influence on serum total or essential amino acids.Conclusions: The current study demonstrated that the combined oral administration of glycine and tryptophan significantly elevated the eGFR of healthy participants. However, further investigation is required to elucidate the detailed mechanisms underlying the potential therapeutic or preventive effect of combined glycine and tryptophan supplementation. Nevertheless, the uric acid-lowering effect of glycine and tryptophan mixture has the potential to directly influence renal function.Keywords: glycine, tryptophan, estimated glomerular filtration rate, uric acid

Glomerular Filtration Rate, Potentially the Missed Link Between Serum Uric Acid and Erectile Dysfunction

2014 ◽  
Vol 11 (12) ◽  
pp. 3125-3127
Author(s):  
Leonardo Oliveira Reis ◽  
Marina Zamuner ◽  
Brunno C.F. Sanches ◽  
Osamu Ikari
Keyword(s):  
Uric Acid ◽  
Glomerular Filtration Rate ◽  
Erectile Dysfunction ◽  
Glomerular Filtration ◽  
Serum Uric Acid ◽  
Filtration Rate
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