Serum uric acid levels and decreased estimated glomerular filtration rate in patients with type 2 diabetes: A cohort study and meta-analysis

2018 ◽  
Vol 34 (7) ◽  
pp. e3046 ◽  
Author(s):  
Jing Wang ◽  
Yongkai Yu ◽  
Xiaowen Li ◽  
Dong Li ◽  
Chengwei Xu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Uric Acid ◽  
Cohort Study ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Serum Uric Acid ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Meta Analysis

scholarly journals Serum Uric Acid Levels and Risk of Rapid Decline of Estimated Glomerular Filtration Rate in Patients with Type 2 Diabetes: Findings from a 5-Year Prospective Cohort Study

Healthcare ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1341
Author(s):  
Hoa Tuyet Le ◽  
Tung Thanh Le ◽  
Nguyet Minh Thi Tran ◽  
Thuy Thanh Thi Nguyen ◽  
Ni Chanh Su Minh ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Uric Acid ◽  
Cohort Study ◽  
Glomerular Filtration Rate ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Rapid Decline ◽  
Rapid Progression

This study investigated the association between serum uric acid (SUA) levels with rapid decline of the estimated glomerular filtration rate (eGFR) in type 2 diabetes (T2 DM) patients. A prospective cohort study was conducted in a community-based hospital in Vietnam. We followed 405 T2DM patients with normal kidney function for five years. Rapid progression of kidney function was defined as an average annual decrease of eGFR of at least 4 mL/min/1.73 m2 and was found in 16.0% of patients. Patients in the SUA high tertile ( ≥6 mg/dL) had higher BMI (p = 0.004), lower HbA1c (p = 0.001), lower eGFR (p < 0.001) and higher rate of hypertension than low and middle tertile. After adjusting for age and sex, rapid progression of renal function was significantly associated with SUA level (OR = 1.22, 95% CI 1.02–1.45, p = 0.026). This association was marginally significant when more covariates were included in the model (OR = 1.20, 95% CI 0.99–1.46, p = 0.065). However, the association between tertiles of SUA and rapid decline of eGFR was not statistically significant. This study demonstrates neither a strong significant association between SUA and rapid decline of eGFR nor evidence to refuse the role of SUA levels in the increased risk of renal function decline in in T2DM patients.

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