Biomarkers and Clinical Indices of Aging with HIV

2016 ◽  
pp. 47-58 ◽  
Author(s):  
Kathleen V. Fitch ◽  
Meghan Noonan Feldpausch ◽  
Sara E. Dolan Looby
Keyword(s):  
Clinical Indices

Clinical effectiveness of the composition of muramylpeptides from gram-negative bacteria in the treatment of severe chronic generalized periodontitis

2020 ◽  
pp. 24-29
Author(s):  
A.I. Grudyanov ◽  
E.V. Fomenko ◽  
O.V. Kalyuzhin
Keyword(s):  
Clinical Effectiveness ◽  
Main Group ◽  
Control Group ◽  
Gram Negative Bacteria ◽  
Periodontal Pathogens ◽  
Gram Negative ◽  
Periodontal Inflammation ◽  
Clinical Indices ◽  
Periodontal Indices

The effectiveness of the immunomodulator Polymuramil (PM) was determined in the treatment of 40 patients with severe chronic generalized periodontitis based on the dynamics of the values of periodontal indices and the content of periodontal pathogens in the periodontal pockets. Patients of the main group (20 people) were treated with professional hygiene (PGO) in combination with daily intramuscular PM for 5 days at a dose of 200 mcg. Patients of the control group (20 people) were performed only PGO. The effectiveness of treatment was evaluated based on the dynamics of the clinical indices of Muehlemann and PMA and the presence or absence of major periodontal pathogens in the periodontal pockets. Results: in patients of the main group, the phenomena of periodontal inflammation and the main periodontal pathogens were eliminated in a shorter time and to a greater extent in comparison with patients of the control group

scholarly journals Prevalence and clinical indices of risk for sexual and gender minority youth in an adolescent inpatient sample

2020 ◽  
Vol 130 ◽  
pp. 327-332 ◽  
Author(s):  
Alexandra H. Bettis ◽  
Elizabeth C. Thompson ◽  
Taylor A. Burke ◽  
Jacqueline Nesi ◽  
Anastacia Y. Kudinova ◽  
...  
Keyword(s):  
Minority Youth ◽  
Gender Minority ◽  
Adolescent Inpatient ◽  
Clinical Indices ◽  
Sexual And Gender Minority ◽  
And Gender

scholarly journals P106 Depressive symptoms and anxiety and their screening in IBD patients: performance of the distress thermometer in Italian IBD patients

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S188-S189
Author(s):  
C Canaletti ◽  
F Colombo ◽  
A Dessì ◽  
E Geccherle ◽  
A Tongiorgi ◽  
...  
Keyword(s):  
Psychological Distress ◽  
Emotional Distress ◽  
Screening Tool ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Cutoff Score ◽  
Distress Screening ◽  
Single Item ◽  
Mayo Score ◽  
Clinical Indices

Abstract Background Roughly 50% of patients with IBD have symptoms of psychological distress (Mikocka-Walus et al. 2019) but only 15.2% receive attention for their mental health although the effect on disease severity can be profound. It is necessary to have an easy-to-administer psychological distress screening tool. The distress thermometer (DT) is a single-item distress screening scale with 11-likert response widely used in oncological patients. The aim of study was to determine whether the single-item DT compared favourably with IBD clinical indices and time consuming measures currently used to screen for distress. Methods Two hundered and twenty IBD patients (51.43% male) who were recruited in eight Italian hospitals completed the DT and identified the presence or absence of 34 problems using standardised problem list (PL). They completed the 14-item Hospital Anxiety and Depression Scale (HADS) and the 32-item Inflammatory Bowel Disease Questionnaire (IBDQ). Disease clinical indices have been collected for each patient (Mayo score, Harvey–Bradshaw Index–HBI, years of illness, and exacerbation in the last year). Using receiver operating characteristic (ROC) analyses validated the use of the DT in Italian IBD population. Results 47.6% reported anxiety and depression symptoms (HADS ≥15) and needs emotional care. Anxiety is much more associated (43.8%) than depressive problems (26.2%). Data are confirmed by responses to DT and PL: 44.5% of patients reported moderate–severe emotional distress (TD ≥ 5), 43.1% of patients report nervousness and worry, 27.1% reported depression. We observed a strong positive correlation between IBDQ and HADS (r = 0.74, p < 0.001) and DT (r = 0.58, p < 0.001), while there was a slightly smaller association with Mayo score (r = 0.46, p < 0.001) and HBI (r = 0.39, p < 0.001). There was not a statistical significant correlation between disease indices and the emotional distress as measured by HADS or DT. ROC analyses showed that a DT cutoff score of 5 or higher had optimal sensitivity (83%) and specificity (68%) relative to the HADS score as ‘gold’ standard. DT scores yielded area under the curve estimates relative to the HADS cutoff score indicative of good overall accuracy (AUC = 0.81–95% CI: 0.77–0.85). Conclusion Our study confirms that anxiety and depression symptoms are associated with IBD. This is the first study that demonstrated that DT is an easy-to-administer screening tool of psychosocial distress in IBD population. We propose that gastroenterologists use DT to identify patients with psychological distress: an early psychological support and a multidisclinar equipe can determinate a patient’s better disease course (Mawdsley et al. 2005). Our analyses indicated that using a DT’s cutoff of 5 to indicate high levels of distress.

Clinical indices of institutional stress in relocating to a new hospital

2011 ◽  
Vol 26 (S2) ◽  
pp. 1462-1462
Author(s):  
J.R. Nurenberg ◽  
S. Schleifer
Keyword(s):  
State Hospital ◽  
Hospital Planning ◽  
Before And After ◽  
Clinical Indices ◽  
Hospital Population ◽  
New Facility

Relocating an entire state hospital population to a new facility poses stress for patients and staff. Preparation for 414 patients (57% hospitalized >2 years) proceeded over 18 months. Several scales for each patient: BPRS, a 4-point transition scale (“none” to “a lot”), and the 5-point Greystone Intrusiveness Measure (GIM) completed. Data are available for 195 patients both before and after the move. Total BPRS decreased from 41.4 + 13.0 < mean+/−sd> to 34.7 + 14.6 (paired t = 6.5, df 194, p < 0.001), and mean GIM from 2.13 + 1.28 to 1.78 + 1.12 (t = 3.8, df 193, p < 0.001). GIM pre-move correlated with concurrent (r = 0.43, p < 0.001) and post-move (r = .24, p < 0.001) BPRS. Anticipated difficulty (35% some/11% a lot) was associated with pre-move BPRS (r = .33;p < 0.001) and GIM (r = .28, p < 0.001), but to only a lesser degree with post-move BPRS (r = .18;p < 0.02) and GIM (r = .16;p < 0.03). Reported post-move difficulties (23% some/6% a lot) were less than expected (t = 3.3, df 194, p < 0.001) and not associated with anticipated difficulties (r = 0.06, p ns). Only 37% of those predicted were reported to have post-move difficulty. Post-move difficulty was associated with pre-move BPRS (r = 0.21, p < 0.01) and GIM (r = 0.17, p < 0.02), more so with the concurrent post-move BPRS (r = 0.46, p < 0.001) and GIM (r = 0.58, p < 0.001). Hospital-wide antipsychotic polypharmacy spiked preceding the move, returning toward baseline in the post-move months. The findings suggest that anticipation of the event was associated with greater clinical stress than the move. The extensive hospital planning may account for both high anticipatory stress and reduced adverse consequences post-move. Clinicians have only a modest ability to predict who will have difficulty with clinical transitions.

Application of clinical indices of fetal growth and wellbeing to a novel laboratory species, the spiny mouse

2008 ◽  
Vol 8 (3) ◽  
pp. 229-243 ◽  
Author(s):  
Hayley Dickinson ◽  
Tania Griffiths ◽  
David W. Walker ◽  
Graham Jenkin
Keyword(s):  
Fetal Growth ◽  
Spiny Mouse ◽  
Clinical Indices

scholarly journals BANA-Positive Plaque Samples Are Associated with Oral Hygiene Practices and Not CD4+ T Cell Counts in HIV-Positive Patients

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Cathy Nisha John ◽  
Lawrence Xavier Graham Stephen ◽  
Charlene Wilma Joyce Africa
Keyword(s):  
T Cell ◽  
Periodontal Disease ◽  
Oral Hygiene ◽  
Periodontal Diseases ◽  
Cd4 T Cell ◽  
Hiv Positive ◽  
Hygiene Practices ◽  
Cell Counts ◽  
Probing Depth ◽  
Clinical Indices

Background. The “red complex” microorganisms, namely,Porphyromonas gingivalis,Treponema denticola, andTannerella forsythiaare considered as potential pathogens causing HIV-associated periodontal diseases. Moreover, it has been recognized that an association exists between CD4+ T cell counts and periodontal disease progression.Objective. To establish whether CD4+ T cell counts or oral hygiene plays a greater role in producing BANA-positive results in HIV-associated periodontal disease.Materials and Methods. One hundred and twenty HIV-positive patients participated in the study, and their CD4+ T cell counts were obtained from their medical records. The six Ramfjord teeth were used for evaluating periodontal clinical indices and subgingival plaque sampling. BANA test was used for the detection and prevalence of the “red complex” bacteria in plaque samples.Results. A majority of 69.17% HIV-positive patients were BANA-positive. No significant associations were found between BANA and CD4+ T cell counts. A highly significant association was found between BANA with probing depth and clinical attachment level (P≤0.0001) and between BANA and the use of interdental aids (P=0.0168).Conclusion. HIV-associated periodontal diseases are strongly related to oral hygiene practices rather than the effect of CD4+ T cell counts, and the use of interdental aids was marked as a significant predictor of BANA-negative plaque samples.

Abstract 11906: Heart Failure Admissions to General Medicine Services are Associated With Increased 30-day Readmission Rate

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Parag Goyal ◽  
Madeline Sterling ◽  
Ashley N Beecy ◽  
Savira Kochhar ◽  
John T Ruffino ◽  
...  
Keyword(s):  
Heart Failure ◽  
Readmission Rate ◽  
General Medicine ◽  
Structural Heart Disease ◽  
Multivariate Regression Analysis ◽  
Readmission Rates ◽  
Modifiable Factors ◽  
Patients With Heart Failure ◽  
Hospital Patients ◽  
Clinical Indices

Introduction: Hospitalists are increasingly caring for patients with heart failure (HF) at a time when there is need to identify modifiable factors associated with 30-day readmission rates. Hypothesis: Patients admitted to General Medicine services (GM) will have higher 30-day readmission rates than those admitted to Cardiology services. Methods: This retrospective cohort comprised patients with a principal diagnosis of HF discharged from GM or Cardiology services in 2013-2014 at an urban academic hospital. Patients discharged with hospice were excluded. Index hospitalizations and 30-day readmissions were identified via query of the electronic medical records. Demographics, clinical indices, and hospitalization characteristics were collected by chart review. Results: Among 926 patients admitted with HF, 40% were admitted to GM and 60% were admitted to a Cardiology service. Patients on GM were slightly older, more likely female, and more likely to have Medicare (Table). They also had higher LVEF, less RV dysfunction, and less ventricular tachycardia (VT). Rates of non-cardiac comorbidities were comparable between groups. Patients on GM experienced a 1.4-fold increased 30-day readmission rate compared to those on Cardiology services (32% vs. 23%, p=0.023). Multivariate regression analysis showed that admission to GM remained a predictor for 30-day readmission (OR 1.37, [1.01 to 1.87], p=0.048) after controlling for key differences between groups including age, sex, insurance, LVEF, RV dysfunction, VT, and admission blood pressure and hemoglobin. Conclusions: HF patients admitted to General Medicine have less structural heart disease, and yet have a higher rate of 30-day readmission compared to those admitted to Cardiology services. This underscores the importance of ensuring that hospitalists obtain adequate heart failure training (related to both inpatient care and optimization of discharge regimens), so as to avoid un-necessary readmissions.

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