scholarly journals Metastatic Angiosarcoma with Kasabach-Merritt Syndrome Responsive to Gemcitabine and Vinorelbine after Failure of Liposomal Doxorubicin and Paclitaxel: A Case Report

2016 ◽  
Vol 9 (1) ◽  
pp. 177-181 ◽  
Author(s):  
William L. Read ◽  
Felicia Williams
Keyword(s):  
Case Report ◽  
Disease Progression ◽  
Liposomal Doxorubicin ◽  
Vascular Tumors ◽  
Kaposiform Hemangioendothelioma ◽  
Consumptive Coagulopathy

Kasabach-Merritt syndrome (KMS) describes a consumptive coagulopathy associated with certain vascular tumors. It is thought that platelets are destroyed as they circulate through the aberrant endothelial surfaces associated with these tumors. Most published literature describes infants with kaposiform hemangioendothelioma, but a similar syndrome can complicate angiosarcoma in adults. This report describes a man with metastatic angiosarcoma arising in the scalp in whom disease progression was complicated by profound thrombocytopenia consistent with KMS. His disease and associated KMS had progressed previously through paclitaxel and then through liposomal doxorubicin. It did not respond to paclitaxel and bevacizumab, but responded almost completely to chemotherapy with gemcitabine and vinorelbine. Six months later, progression through ongoing chemotherapy then responded to chemotherapy with cyclophosphamide and sirolimus.

scholarly journals The impact of mental health on COVID 19 disease progression: Case report

2021 ◽  
pp. 102543
Author(s):  
Amine Bouabdallaoui ◽  
Salma Taouihar ◽  
Ghizlane El Aidouni ◽  
Mohamed Aabdi ◽  
Rajae Alkouh ◽  
...  
Keyword(s):  
Mental Health ◽  
Case Report ◽  
Disease Progression ◽  
The Impact

scholarly journals Primitive neuroectodermal tumor of the esophagus with metastasis in the pineal gland

2019 ◽  
Vol 07 (09) ◽  
pp. E1163-E1165
Author(s):  
Leonardo Blas Jhon ◽  
Paloma Sánchez-Fayos ◽  
Maria Jesus Martín Relloso ◽  
Daniel Calero Barón ◽  
Juan Carlos Porres Cubero
Keyword(s):  
Case Report ◽  
Pineal Gland ◽  
Disease Progression ◽  
Rare Case ◽  
Primitive Neuroectodermal Tumor ◽  
Malignant Neoplasms ◽  
Primitive Neuroectodermal Tumors ◽  
First Case ◽  
Neuroectodermal Tumors ◽  
Chemotherapeutic Treatment

AbstractPrimitive neuroectodermal tumors (PNET) are very rare tumors that belong to a family of malignant neoplasms of tiny round cells which are derived from the neural crest. This report discusses a rare case of an adult woman with esophageal PNET, confirmed by immunohistochemistry, that presented with metastasis to the pineal gland. To our knowledge, this is the first case report of a PNET with these features. Despite surgery and chemotherapeutic treatment, our case has shown disease progression.

Pediatric Anastomosing Hemangioma: Case Report and Review of Renal Vascular Tumors in Children

2018 ◽  
Vol 22 (3) ◽  
pp. 269-275 ◽  
Author(s):  
Alvin B Caballes ◽  
Agustina D Abelardo ◽  
Miguel J Farolan ◽  
Januario Antonio D Veloso
Keyword(s):  
Case Report ◽  
Pediatric Patients ◽  
Wilms Tumor ◽  
Vascular Lesion ◽  
Renal Tumors ◽  
Vascular Tumors ◽  
Malignant Neoplasms ◽  
Therapeutic Implications ◽  
Renal Vascular ◽  
Anastomosing Hemangioma

The case involves a 10-year-old child who underwent a left radical nephrectomy for what was believed to be a Wilms’ tumor. Histopath examination indicated a benign vascular lesion, subsequently determined to be an anastomosing hemangioma of the kidney. A comparison with the previously cited pediatric patients with renal vascular tumors is provided, and the inconsistent diagnostic terminologies for these conditions are highlighted. The therapeutic implications of these predominantly benign renal tumors, in the context of the much more frequently encountered malignant neoplasms in children, are additionally discussed.

scholarly journals Pulmonary Fibrosis after Pegylated Liposomal Doxorubicin in Elderly Patient with Cutaneous Angiosarcoma

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Marco Mazzotta ◽  
Raffaele Giusti ◽  
Daniela Iacono ◽  
Salvatore Lauro ◽  
Paolo Marchetti
Keyword(s):  
Elderly Patient ◽  
Case Report ◽  
Pulmonary Fibrosis ◽  
Pulmonary Toxicity ◽  
Liposomal Doxorubicin ◽  
Pegylated Liposomal Doxorubicin ◽  
The Body ◽  
Rare Cancer ◽  
True Incidence ◽  
First Case

Introduction. Angiosarcoma is a rare cancer of the inner lining of blood vessels and can arise anywhere in the body, most commonly presenting as cutaneous disease in elderly patient, involving head and neck (H&N), especially the scalp. Pegylated liposomal doxorubicin (PLD) is one of the available treatments in patients with advanced or metastatic disease. Common toxicities are myelosuppression, palmar-plantar erythrodysesthesia, nausea, and stomatitis. Regarding PLD-related pulmonary fibrosis in an uncommon toxicity, there are few cases reported in literature. None of these occurred in angiosarcoma.Methods. This is a case report describing an elderly patient treated with PLD for advanced H&N cutaneous angiosarcoma who developed G5 pulmonary toxicity after the second PLD administration.Results. According to our data and patient clinical outcome, we believe that she passed away from fatal PLD-induced pulmonary fibrosis. This is the first case of fatal interstitial pneumonitis in a 77-year-old woman treated with PLD for angiosarcoma. The case has been reported for its rarity.Conclusions. Pathophysiology of this phenomenon is still unclear and more studies are necessary to understand the true incidence of pulmonary toxicities in patients in treatments with PLD and its mechanism.

Pegylated Liposomal Doxorubicin in Combination with Hyperthermia for Treatment of Skin Metastases of Breast Carcinoma: A Case Report

2001 ◽  
Vol 24 (2) ◽  
pp. 166-168 ◽  
Author(s):  
J. Dvořák ◽  
Z. Zoul ◽  
B. Melichar ◽  
P. Jandík ◽  
J. Mergancová ◽  
...  
Keyword(s):  
Case Report ◽  
Breast Carcinoma ◽  
Liposomal Doxorubicin ◽  
Pegylated Liposomal Doxorubicin ◽  
Skin Metastases

scholarly journals Primary Kaposiform Hemangioendothelioma of the Humerus: A Case Report

Cureus ◽  
2022 ◽  
Author(s):  
Zafar Ali ◽  
Syed M Qasim ◽  
Farhan Faisal ◽  
Gulfam Jameel
Keyword(s):  
Case Report ◽  
Kaposiform Hemangioendothelioma
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