scholarly journals Pulmonary Fibrosis after Pegylated Liposomal Doxorubicin in Elderly Patient with Cutaneous Angiosarcoma

2016 ◽  
Vol 2016 ◽  
pp. 1-5 ◽  
Author(s):  
Marco Mazzotta ◽  
Raffaele Giusti ◽  
Daniela Iacono ◽  
Salvatore Lauro ◽  
Paolo Marchetti
Keyword(s):  
Elderly Patient ◽  
Case Report ◽  
Pulmonary Fibrosis ◽  
Pulmonary Toxicity ◽  
Liposomal Doxorubicin ◽  
Pegylated Liposomal Doxorubicin ◽  
The Body ◽  
Rare Cancer ◽  
True Incidence ◽  
First Case

Introduction. Angiosarcoma is a rare cancer of the inner lining of blood vessels and can arise anywhere in the body, most commonly presenting as cutaneous disease in elderly patient, involving head and neck (H&N), especially the scalp. Pegylated liposomal doxorubicin (PLD) is one of the available treatments in patients with advanced or metastatic disease. Common toxicities are myelosuppression, palmar-plantar erythrodysesthesia, nausea, and stomatitis. Regarding PLD-related pulmonary fibrosis in an uncommon toxicity, there are few cases reported in literature. None of these occurred in angiosarcoma.Methods. This is a case report describing an elderly patient treated with PLD for advanced H&N cutaneous angiosarcoma who developed G5 pulmonary toxicity after the second PLD administration.Results. According to our data and patient clinical outcome, we believe that she passed away from fatal PLD-induced pulmonary fibrosis. This is the first case of fatal interstitial pneumonitis in a 77-year-old woman treated with PLD for angiosarcoma. The case has been reported for its rarity.Conclusions. Pathophysiology of this phenomenon is still unclear and more studies are necessary to understand the true incidence of pulmonary toxicities in patients in treatments with PLD and its mechanism.

Pegylated Liposomal Doxorubicin in Combination with Hyperthermia for Treatment of Skin Metastases of Breast Carcinoma: A Case Report

2001 ◽  
Vol 24 (2) ◽  
pp. 166-168 ◽  
Author(s):  
J. Dvořák ◽  
Z. Zoul ◽  
B. Melichar ◽  
P. Jandík ◽  
J. Mergancová ◽  
...  
Keyword(s):  
Case Report ◽  
Breast Carcinoma ◽  
Liposomal Doxorubicin ◽  
Pegylated Liposomal Doxorubicin ◽  
Skin Metastases

scholarly journals Solitary Fibrous Tumor of the Postcricoid Region: A Case Report and Literature Review

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Brian Cervenka ◽  
Brenda Villegas ◽  
Uttam Sinha
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Solitary Fibrous Tumor ◽  
Management Strategies ◽  
The Body ◽  
Surgical Approaches ◽  
Current Management ◽  
First Case ◽  
Mesenchymal Neoplasm ◽  
Fibrous Tumor

Solitary fibrous tumor (SFT) is a rare mesenchymal neoplasm that can present essentially anywhere in the body. Presentations in the hypopharynx are extremely rare with only two previous cases reported. We report the first case of postcricoid SFT occurring in a 58-year-old male requiring a microsuspension laryngoscopy excision following an unsuccessful transoral robotic attempt. The excision was uneventful, and the patient is currently without recurrence. Current management strategies of the hypopharyngeal SFT, the unique differential diagnosis, and challenges in surgical approaches in the postcricoid region are discussed.

scholarly journals Breast implant-associated anaplastic large cell lymphoma in an Asian patient: The first case report from Thailand

2020 ◽  
Vol 47 (5) ◽  
pp. 478-482
Author(s):  
Peera Thienpaitoon ◽  
Wareeporn Disphanurat ◽  
Naree Warnnissorn
Keyword(s):  
Case Report ◽  
Anaplastic Large Cell Lymphoma ◽  
Breast Augmentation ◽  
Cell Lymphoma ◽  
Breast Implant ◽  
Large Cell ◽  
The United States ◽  
True Incidence ◽  
First Case ◽  
Large Cell Lymphoma

Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) has received increasing interest among plastic surgeons as a long-term complication of breast augmentation. Although the prognosis is usually good, mortality is a possible outcome. Most of the cases reported in the past two decades have been from the United States, Europe, and Australia, whereas cases of BIA-ALCL in Asia remain rare. Herein, we describe the first known case of BIA-ALCL in Thailand, in which a 32-year-old woman developed BIA-ALCL 3 years after breast augmentation using textured implants. The patient underwent bilateral removal of the implants and ipsilateral total capsulectomy. This case report—the first of its kind from Thailand—should increase awareness of BIA-ALCL among plastic surgeons in Asia. The true incidence of BIA-ALCL in Asia may be underreported.

scholarly journals Histological evidence for the cardiac safety of high-dose pegylated liposomal doxorubicin in a patient with HIV-associated Kaposi sarcoma: a case report and literature review

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Ayaka Ishihara ◽  
Shuji Hatakeyama ◽  
Jun Suzuki ◽  
Yusuke Amano ◽  
Teppei Sasahara ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Cumulative Dose ◽  
Liposomal Doxorubicin ◽  
Cardiac Toxicity ◽  
Pegylated Liposomal Doxorubicin ◽  
Kaposi Sarcoma ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction

Abstract Background Pegylated liposomal doxorubicin plays an important role in the treatment of patients with severe refractory human immunodeficiency virus (HIV)-associated Kaposi sarcoma (KS). High cumulative doses of conventional doxorubicin exceeding 500 mg/m2 are known to cause cardiac toxicity. However, the safe cumulative dose of pegylated liposomal doxorubicin is unclear. Case presentation A 40-year-old Japanese man with HIV infection presented with pain, edema, and multiple skin nodules on both legs which worsened over several months. He was diagnosed with HIV-associated KS. He received long-term pegylated liposomal doxorubicin combined with antiretroviral therapy for advanced, progressive KS. The cumulative dose of pegylated liposomal doxorubicin reached 980 mg/m2. The patient’s left ventricular ejection fraction remained unchanged from baseline during treatment. After he died as a result of cachexia and wasting, caused by recurrent sepsis and advanced KS, an autopsy specimen of his heart revealed little or no evidence of histological cardiac damage. We also conducted a literature review focusing on histological changes of the myocardium in patients treated with a cumulative dose of pegylated liposomal doxorubicin exceeding 500 mg/m2. Conclusions This case report and literature review suggest that high (> 500 mg/m2) cumulative doses of pegylated liposomal doxorubicin may be used without significant histological/clinical cardiac toxicity in patients with HIV-associated KS.

Primary Epithelioid Rhabdomyosarcoma of the Liver: Case Report of an Unusual Histological Variant

2021 ◽  
pp. 106689692110498
Author(s):  
Harumi Nakamura ◽  
Yuki Koyanagi ◽  
Masanori Kitamura ◽  
Yoji Kukita
Keyword(s):  
Case Report ◽  
Striated Muscle ◽  
Fusion Gene ◽  
Liver Lesion ◽  
The Body ◽  
Base Substitution ◽  
Entire Body ◽  
Positive Ratio ◽  
First Case ◽  
Histological Variant

Rhabdomyosarcoma (RMS) is a soft tissue tumor with striated muscle cell differentiation. It mostly occurs in children. While it can affect any part of the body, it commonly involves the urogenital organs, head and neck including the parameninges and orbit, and limbs. We describe an adult case of primary epithelioid RMS of the liver. A 71-year-old man presented with a 5.6 cm liver mass. Tumor histology revealed diffuse proliferation of small epithelioid cells and focal spindle cells. The tumor cells were immunohistochemically positive for myogenin (positive ratio 30%), desmin, Myo D1, and CD56. The tumor weakly expressed MDM2 and did not express CDK4. This suggested that dedifferentiated liposarcoma with a rhabdomyosarcomatous component was unlikely. There was no fusion gene of PAX3-FKHR or PAX7- FKHR to indicate alveolar RMS by RT-PCR. Subsequently, RNA Pan-Cancer Targeted sequencing was performed for 1385 genes revealed a single base substitution (c.742C>T) in TP53 that changes an amino acid (p.Arg248Trp). No fusion gene was found. No other primary RMS lesions were detected aside from the liver lesion. The tumor was diagnosed as a primary epithelioid RMS of the liver. His RMS already metastasized to the lymph nodes of the entire body. The patient declined further therapy and died one year later. This was the first case report of a primary epithelioid RMS of the liver.

scholarly journals Laryngeal Inflammatory Pseudotumour Secondary to Mycobacterium kansasii

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Saif Al-Zahid ◽  
Tanwen Wright ◽  
Philip Reece
Keyword(s):  
Case Report ◽  
Multidisciplinary Approach ◽  
The Body ◽  
Mycobacterium Kansasii ◽  
Mycobacterial Disease ◽  
Inflammatory Pseudotumour ◽  
First Case ◽  
Benign Tumours ◽  
High Index Of Suspicion ◽  
Work Up

Background. Inflammatory pseudotumours (IPT) are rare benign tumours characterised by spindle-shaped histiocyte proliferation often mimicking a soft tissue sarcoma. They can occur in different parts of the body and various aetiological factors have been proposed. To our knowledge this is the first case report of IPT of the larynx caused by mycobacterial disease. Case Report. We report a case of IPT of the larynx in an immunocompromised 81-year-old lady presenting with stridor and dysphagia with known disseminated Mycobacterium kansasii of the lungs. Conclusion. This case demonstrates both the clinical and histological difficulties in making the diagnosis of IPT. A high index of suspicion is needed, and the importance of a multidisciplinary approach in the work-up, diagnosis, and management is highlighted.

scholarly journals Transoral Laser Surgery for Adenosquamous Carcinoma of the Glottis: First Case Report and Review of the Literature

2020 ◽  
pp. 014556132091657
Author(s):  
William Kendall ◽  
Panagiotis A. Dimitriadis ◽  
Fawzia Tahir ◽  
Sara Sionis
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Laser Surgery ◽  
Poor Prognosis ◽  
Adenosquamous Carcinoma ◽  
Severe Dysplasia ◽  
Rare Cancer ◽  
Review Of The Literature ◽  
First Case ◽  
Disease Free

Adenosquamous carcinoma of the head and neck is a rare cancer associated with poor prognosis. Histologically, it is identified through the presence of both adenocarcinoma and squamous cell carcinoma, although it may be difficult to diagnose from initial endoscopic biopsies. We report a case of adenosquamous carcinoma of the glottis in an 82-year-old female patient who presented with progressive hoarseness of voice and in whom initial biopsies had shown only moderate to severe dysplasia. This is the first case in the literature of a primary adenosquamous carcinoma of the glottis managed successfully with a CO2 laser left type Va cordectomy. The patient remained disease-free 28 months postoperatively.

Atypical Fibroxanthoma

2001 ◽  
Vol 110 (10) ◽  
pp. 985-987 ◽  
Author(s):  
Ishrat Hakim
Keyword(s):  
Elderly Patient ◽  
Case Report ◽  
Soft Tissue ◽  
Wide Local Excision ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Dermatofibrosarcoma Protuberans ◽  
Tissue Preservation ◽  
Atypical Fibroxanthoma ◽  
First Case

This is the first case report of atypical fibroxanthoma in the otolaryngology literature. Atypical fibroxanthoma is a rare fibrohistiocytic tumor that occurs on actinically damaged skin. The typical presentation is a nodular lesion in sun-exposed areas of the head and neck in an elderly patient. Differentiating atypical fibroxanthoma from other soft tissue sarcomas, such as dermatofibrosarcoma protuberans and malignant fibrous histiocytoma, can be difficult. Treatment should be wide local excision with a 1-cm margin. In cosmetically important regions in which tissue preservation is important, Mohs' surgery should be considered.

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