Isobolographic Analysis of Interaction for Three-Drug Combination of Carbamazepine, Phenobarbital and Topiramate in the Mouse Maximal Electroshock-Induced Seizure Model

Pharmacology ◽  
2016 ◽  
Vol 97 (5-6) ◽  
pp. 259-264 ◽  
Author(s):  
Jarogniew J. Luszczki
Keyword(s):  
Drug Combination ◽  
Maximal Electroshock ◽  
Isobolographic Analysis ◽  
Seizure Model

Synergistic Interaction of Retigabine with Levetiracetam in the Mouse Maximal Electroshock-Induced Seizure Model: A Type II Isobolographic Analysis

Pharmacology ◽  
2015 ◽  
Vol 96 (1-2) ◽  
pp. 11-15 ◽  
Author(s):  
Jarogniew J. Luszczki ◽  
Mirosław Zagaja ◽  
Barbara Miziak ◽  
Magdalena Florek-Luszczki ◽  
Stanislaw J. Czuczwar
Keyword(s):  
Synergistic Interaction ◽  
Maximal Electroshock ◽  
Type Ii ◽  
Isobolographic Analysis ◽  
Seizure Model

scholarly journals Interactions among Lacosamide and Second-Generation Antiepileptic Drugs in the Tonic-Clonic Seizure Model in Mice

2021 ◽  
Vol 22 (11) ◽  
pp. 5537
Author(s):  
Katarzyna Załuska-Ogryzek ◽  
Paweł Marzęda ◽  
Paula Wróblewska-Łuczka ◽  
Magdalena Florek-Łuszczki ◽  
Zbigniew Plewa ◽  
...  
Keyword(s):  
Second Generation ◽  
Screen Test ◽  
Clonic Seizure ◽  
Tonic Clonic Seizure ◽  
Maximal Electroshock ◽  
Isobolographic Analysis ◽  
Clonic Seizures ◽  
Seizure Model

Combination therapy with two or three antiseizure medications (ASMs) is sometimes a preferred method of treatment in epilepsy patients. (1) Background: To detect the most beneficial combination among three ASMs, a screen test evaluating in vivo interactions with respect to their anticonvulsant properties, was conducted on albino Swiss mice; (2) Methods: Classification of interactions among lacosamide (LCM) and selected second-generation ASMs (lamotrigine (LTG), pregabalin (PGB), oxcarbazepine (OXC), and topiramate (TPM)) was based on the isobolographic analysis in the mouse maximal electroshock-induced seizure (MES) model. Interactions among LCM and second-generation ASMs were visualized using a polygonogram; (3) Results: In the mouse MES model, synergy was observed for the combinations of LCM + TPM + PGB and LCM + OXC + PGB. Additivity was reported for the other combinations tested i.e., LCM + LTG + TPM, LCM + LTG + PGB, LCM + LTG + OXC, and LCM + OXC + TPM in this seizure model. No adverse effects associated with triple ASM combinations, containing LCM and second-generation ASMs were observed in mice; (4) Conclusions: The combination of LCM + TPM + PGB was the most beneficial combination among the tested in this study, offering synergistic suppression of tonic-clonic seizures in mice subjected to the MES model. Both the isobolographic analysis and polygonogram method can be recommended for experimental epileptology when classifying interactions among the ASMs.

scholarly journals Effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline on the protective action of various antiepileptic drugs in the maximal electroshock-induced seizure model: a type II isobolographic analysis

2013 ◽  
Vol 120 (12) ◽  
pp. 1651-1663 ◽  
Author(s):  
Marta Andres-Mach ◽  
Anna Zadrożniak ◽  
Agnieszka Haratym-Maj ◽  
Magdalena Florek-Luszczki ◽  
Grzegorz Raszewski ◽  
...  
Keyword(s):  
Antiepileptic Drugs ◽  
Protective Action ◽  
Maximal Electroshock ◽  
Type Ii ◽  
Isobolographic Analysis ◽  
Seizure Model
Sign in / Sign up

Export Citation Format

Share Document