Prospective Evaluation of a Panel of Plasma Cytokines and Chemokines as Potential Markers of Pelvic Endometriosis in Symptomatic Women

2016 ◽  
Vol 81 (6) ◽  
pp. 512-517 ◽  
Author(s):  
Ana Luiza Rocha ◽  
Erica L. Vieira ◽  
Laura M. Maia ◽  
Antônio Lúcio Teixeira ◽  
Fernando M. Reis
Keyword(s):  
Pelvic Endometriosis ◽  
Prospective Evaluation ◽  
Cytokines And Chemokines ◽  
Plasma Cytokines

Kinetics of plasma cytokines and chemokines during primary HIV-1 infection and after analytical treatment interruption

HIV Medicine ◽  
2009 ◽  
Vol 10 (2) ◽  
pp. 94-102 ◽  
Author(s):  
B Barqasho ◽  
P Nowak ◽  
A Tjernlund ◽  
S Kinloch ◽  
L-E Goh ◽  
...  
Keyword(s):  
Treatment Interruption ◽  
Analytical Treatment ◽  
Cytokines And Chemokines ◽  
Plasma Cytokines ◽  
Kinetics Of ◽  
Hiv 1

scholarly journals IL-6 and IL-8 cytokines are associated with elevated prostate-specific antigen levels among patients with adenocarcinoma of the prostate at the Uganda Cancer Institute

2021 ◽  
Author(s):  
Paul Katongole ◽  
Obondo J Sande ◽  
Sheilla Nabweyambo ◽  
Moses Joloba ◽  
Henry Kajumbula ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Prostate Specific Antigen ◽  
Proinflammatory Cytokines ◽  
Specific Antigen ◽  
Cytokines And Chemokines ◽  
Cancer Pathogenesis ◽  
Significant Difference ◽  
Plasma Cytokines ◽  
Potential Biomarkers

Background: The possible clinical application of specific cytokines and chemokines contributing to tumorigenesis and the clinical outcome of several cancers has been reported. However, less invasive and easily applicable biomarkers in Prostate cancer diagnosis and prognostication are still lacking. This study assessed the levels of plasma cytokines in prostate cancer patients as potential biomarkers for noninvasive early diagnosis. Methods: The plasma levels of nine cytokines, IL-6, IL-8, IL-10, IL-1β, IL-17A, IL-2, M-CSF, IL-12 and IFN-α, were detected by Luminex liquid array-based multiplexed immunoassays in 56 prostate cancer patients on androgen deprivation therapy and radiotherapy and 27 normal healthy controls. Results: Levels of plasma proinflammatory cytokines IL-6 and IL-8 were markedly increased in prostate cancer patients compared with controls. There was, however, no significant difference in the concentrations of all cytokines in prostate cancer patients compared with controls. Increasing levels of IL-6 and IL-8 were significantly associated with high levels of plasma prostate-specific antigen (p < 0.05). Conclusion: Proinflammatory cytokines IL-6 and IL-8 are potential biomarkers for prostate cancer pathogenesis and could serve as markers of disease progression.

scholarly journals Plasma Cytokines and Chemokines in Primary Graft Dysfunction Post-Lung Transplantation

2009 ◽  
Vol 9 (2) ◽  
pp. 389-396 ◽  
Author(s):  
S. A. Hoffman ◽  
L. Wang ◽  
C. V. Shah ◽  
V. N. Ahya ◽  
A. Pochettino ◽  
...  
Keyword(s):  
Lung Transplantation ◽  
Primary Graft Dysfunction ◽  
Graft Dysfunction ◽  
Cytokines And Chemokines ◽  
Plasma Cytokines

scholarly journals Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease: A Comparative Study Involving Different Biological Agents

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Ryuji Ohashi ◽  
Ryuji Fukazawa ◽  
Makoto Watanabe ◽  
Hanako Tajima ◽  
Noriko Nagi-Miura ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Alternative Therapy ◽  
Suppressive Effect ◽  
Water Soluble ◽  
Ivig Treatment ◽  
Cytokines And Chemokines ◽  
Plasma Cytokines ◽  
Active Inflammation ◽  
Necrosis Factor

Coronary arteritis, a complication of Kawasaki disease (KD), can be refractory to immunoglobulin (IVIG) treatment. To determine the most effective alternative therapy, we compared the efficacy of different agents in a mouse model of KD. Vasculitis was induced by injection ofCandida albicanswater-soluble fractions (CAWS) into a DBA/2 mouse, followed by administration of IVIG, etanercept, methylprednisolone (MP), and cyclosporine-A (CsA). At 2 and 4 weeks, the mice were sacrificed, and plasma cytokines and chemokines were measured. CAWS injection induced active inflammation in the aortic root and coronary arteries. At 2 weeks, the vasculitis was reduced only by etanercept, and this effect persisted for the subsequent 2 weeks. At 4 weeks, IVIG and CsA also attenuated the inflammation, but the effect of etanercept was more significant. MP exerted no apparent effect at 2 or 4 weeks. The suppressive effect exerted by etanercept on cytokines, such as interleukin- (IL-)6, IL-12, IL-13, and tumor necrosis factor-α(TNF-α), was more evident than that of others. The extent of arteritis correlated with the plasma TNF-αlevels, suggesting a pivotal role of TNF-αin KD. In conclusion, etanercept was most effective in suppressing CAWS-induced vasculitis and can be a new therapeutic intervention for KD.

Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection

2013 ◽  
Vol 66 (4) ◽  
pp. 357-365 ◽  
Author(s):  
Adane Mihret ◽  
Yonas Bekele ◽  
Kidest Bobosha ◽  
Martin Kidd ◽  
Abraham Aseffa ◽  
...  
Keyword(s):  
Active Tuberculosis ◽  
Tuberculosis Infection ◽  
Cytokines And Chemokines ◽  
Plasma Cytokines ◽  
Active Disease

scholarly journals Cytokine and Chemokine Levels in COVID-19 Convalescent Plasma

2020 ◽  
Author(s):  
Tania S Bonny ◽  
Eshan U Patel ◽  
Xianming Zhu ◽  
Evan M Bloch ◽  
M Kate Grabowski ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Blood Donors ◽  
Neutralizing Antibody ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Cytokines And Chemokines ◽  
Plasma Cytokines ◽  
Inflammatory State ◽  
Antibody Titers ◽  
Categorical Groups

Abstract Background The efficacy of COVID-19 convalescent plasma (CCP) is primarily ascribed as a source of neutralizing anti-SARS-CoV-2 antibodies. However, the composition of other immune components in CCP and their potential roles remain largely unexplored. This study aimed to describe the composition and concentrations of plasma cytokines and chemokines in eligible CCP donors. Methods A cross-sectional study was conducted among 20 pre-pandemic healthy blood donors without SARS-CoV-2 infection and 140 eligible CCP donors with confirmed SARS-CoV-2 infection. Electrochemiluminescence detection based multiplexed sandwich immunoassays were used to quantify plasma cytokine and chemokine concentrations (n=35 analytes). A SARS-CoV-2 microneutralization assay was also performed. Differences in the percent detection and distribution of cytokine and chemokine concentrations were examined by categorical groups using Fisher’s exact and Wilcoxon rank-sum tests, respectively. Results Among CCP donors (n=140), the median time since molecular diagnosis of SARS-CoV-2 was 44 days(interquartile range=38-50) and 9%(n=12) were hospitalized due to COVID-19. Compared to healthy blood donor controls, CCP donors had significantly higher plasma levels of IFN-γ, IL-10, IL-15, IL-21 and MCP-1, but lower levels of IL-1RA, IL-8, IL-16, and VEGF-A(P&lt;0.0014). Significant differences were also observed in plasma levels of IL-8, IL-15 and IP-10 between CCP donors with low(&lt;40) vs. high(≥160) anti-SARS-CoV-2 neutralizing antibody titers(P&lt;0.0014). The median levels of IL-6, IL-8, TNF-α, IL-12/IL23p40, MDC were significantly higher among CCP donors who were hospitalized vs. non-hospitalized(P&lt;0.05). Conclusion Heterogeneity in cytokine and chemokine composition of CCP suggests there is a different inflammatory state among the CCP donors as compared to SARS-CoV-2 naïve, healthy blood donors.

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