Plasma cytokines and chemokines differentiate between active disease and non-active tuberculosis infection

2013 ◽  
Vol 66 (4) ◽  
pp. 357-365 ◽  
Author(s):  
Adane Mihret ◽  
Yonas Bekele ◽  
Kidest Bobosha ◽  
Martin Kidd ◽  
Abraham Aseffa ◽  
...  
Keyword(s):  
Active Tuberculosis ◽  
Tuberculosis Infection ◽  
Cytokines And Chemokines ◽  
Plasma Cytokines ◽  
Active Disease

scholarly journals Plasma cytokines and chemokines differentiate between active and non-active tuberculosis infection

2013 ◽  
Vol 4 ◽  
Author(s):  
Mihret Adane ◽  
Bekele Yonas ◽  
Bobosha Kidist ◽  
Kidd Marthin ◽  
Aseffa Abraham ◽  
...  
Keyword(s):  
Active Tuberculosis ◽  
Tuberculosis Infection ◽  
Cytokines And Chemokines ◽  
Plasma Cytokines

scholarly journals Antigen-Specific Cytokine and Chemokine Gene Expression for Diagnosing Latent and Active Tuberculosis

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 716
Author(s):  
Workneh Korma ◽  
Adane Mihret ◽  
Yunhee Chang ◽  
Azeb Tarekegn ◽  
Metasebiya Tegegn ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pulmonary Tuberculosis ◽  
Sensitivity And Specificity ◽  
Interferon Gamma ◽  
Active Tuberculosis ◽  
Tuberculosis Infection ◽  
Tuberculosis Patients ◽  
Cytokines And Chemokines ◽  
Ifn Γ ◽  
Sensitivity Specificity

Tuberculosis infection exhibits different forms, namely, pulmonary, extrapulmonary, and latent. Here, diagnostic markers based on the gene expression of cytokines and chemokines for differentiating between tuberculosis infection state(s) were identified. Gene expression of seven cytokines (Interferon gamma (IFN-γ), Interferon gamma-induced protein 10 (IP-10), Interleukin-2 receptor (IL-2R), C-X-C Motif Chemokine Ligand 9 (CXCL-9), Interleukin 10 (IL-10), Interleukin 4 (IL-4), and Tumor Necrosis Factor alpha (TNF-α)) in response to tuberculosis antigen was analyzed using real-time polymerase reaction. The sensitivity and specificity of relative quantification (2^-ΔΔCt) of mRNA expression were analyzed by constructing receiver operating characteristic curves and measuring the area under the curve (AUC) values. Combinations of cytokines were analyzed using the R statistical software package. IFN-γ, IP-10, IL2R, and CXCL-9 showed high expression in latent and active tuberculosis patients (p = 0.001), with a decrease in IL10 expression, and no statistical difference in IL-4 levels among all the groups (p = 0.999). IL-10 differentiated pulmonary tuberculosis patients from latent cases with an AUC of 0.731. IL10 combined with CXCL-9 distinguished pulmonary tuberculosis patients from extrapulmonary cases with a sensitivity, specificity, and accuracy of 85.7%, 73.9%, and 81.0%, respectively. IL-10 together with IP-10 and IL-4 differentiated pulmonary tuberculosis from latent cases with a sensitivity and specificity of 77.1% and 88.1%, respectively. Decision tree analysis demonstrated that IFN-γ IL-2R, and IL-4 can diagnose tuberculosis infection with a sensitivity, specificity, and accuracy of 89.7%, 96.1%, and 92.7%, respectively. A combination of gene expression of cytokines and chemokines might serve as an effective marker to differentiate tuberculosis infection state(s).

Prospective Evaluation of a Panel of Plasma Cytokines and Chemokines as Potential Markers of Pelvic Endometriosis in Symptomatic Women

2016 ◽  
Vol 81 (6) ◽  
pp. 512-517 ◽  
Author(s):  
Ana Luiza Rocha ◽  
Erica L. Vieira ◽  
Laura M. Maia ◽  
Antônio Lúcio Teixeira ◽  
Fernando M. Reis
Keyword(s):  
Pelvic Endometriosis ◽  
Prospective Evaluation ◽  
Cytokines And Chemokines ◽  
Plasma Cytokines

scholarly journals Probiotic-Based Therapy for Active Tuberculosis Infection: The Role of Gut-Lung Axis and Granulocyte Macrophage-Colony Stimulating Factor

2021 ◽  
Vol 7 (2) ◽  
pp. 93
Author(s):  
Made Indira Dianti Sanjiwani ◽  
Nyoman Budhi Wirananda Setiawan ◽  
Agus Indra Yudhistira Diva Putra ◽  
Agus Eka Darwinata
Keyword(s):  
Potential Role ◽  
Active Tuberculosis ◽  
Tuberculosis Infection ◽  
Colony Stimulating Factor ◽  
Gm Csf ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor ◽  
Global Health Problem

Tuberculosis is a global health problem with a total of 1.4 million cases in 2015. Over the last decade, several studies have demonstrated the potential role of gut-lung axis in the treatment of tuberculosis. The exact mechanism of the gut-lung axis on tuberculosis is still unknown, however modulation of the gut-lung axis can be performed via probiotic administration. The administered probiotics are capable of inducing an immunomodulating effect which helps in the process of tuberculosis infection. One of the molecules that can be activated with probiotics and plays a role in tuberculosis infection is granulocyte macrophage-colony stimulating factor (GM-CSF). GM-CSF can control intracellular production of M. tuberculosis, inflammation in granulomas, and lung tissue reparation. This article aimed to explore the role of the gut-lung axis, GM-CSF, and the potential of probiotic-based therapy on active tuberculosis infection. It was found that probiotics mediate the immune response via the activation of several inflammatory cytokines and interleukins related to lung infection, but not directly with the tuberculosis pathogen. Thus, probiotic-based therapy has the potential to increase immunity during active tuberculosis infection. Further studies to explore the other mechanisms of the gut-lung axis against tuberculosis through probiotic administration need to be performed.

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