scholarly journals Reply to the Letter by Kaya et al. Entitled �Temperature Control Function of the Choroid May Be the Reason for the Increase in Choroidal Thickness During the Acute Phase of Familial Mediterranean Fever'

2016 ◽  
Vol 235 (2) ◽  
pp. 124-124
Author(s):  
Fatih C. Gundogan ◽  
Salih Uzun ◽  
G�khan �zge ◽  
Fahrettin Akay
Keyword(s):  
Familial Mediterranean Fever ◽  
Acute Phase ◽  
Temperature Control ◽  
Choroidal Thickness ◽  
Control Function ◽  
Mediterranean Fever

Retinal and Choroidal Thickness in Children with Familial Mediterranean Fever

2015 ◽  
Vol 23 (6) ◽  
pp. 466-466
Author(s):  
Ahmet Tas ◽  
Umit Yolcu ◽  
Abdullah Ilhan ◽  
Fatih C. Gundogan
Keyword(s):  
Familial Mediterranean Fever ◽  
Choroidal Thickness ◽  
Mediterranean Fever

Choroidal Thickness Changes in the Acute Attack Period in Patients with Familial Mediterranean Fever

2015 ◽  
Vol 235 (2) ◽  
pp. 72-77 ◽  
Author(s):  
Fatih C. Gundogan ◽  
Fahrettin Akay ◽  
Salih Uzun ◽  
Gokhan Ozge ◽  
Sami Toyran ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Choroidal Thickness ◽  
Serum Levels ◽  
Acute Attack ◽  
Clinical Findings ◽  
Healthy Controls ◽  
Reactive Protein ◽  
Mediterranean Fever ◽  
Acute Attacks ◽  
Positive Correlations

Purpose: The aim of this study was to evaluate choroidal thickness changes during acute attacks of familial Mediterranean fever (FMF). Methods: Fifty patients with FMF and 50 healthy controls were included. Choroidal thickness of each participant was measured at the foveola and horizontal nasal and temporal quadrants at 500-µm intervals to 1,500 µm from the foveola using spectral-domain optical coherence tomography. White blood cell count, erythrocyte sedimentation rate (ESR) and serum levels of fibrinogen and C-reactive protein (CRP) were evaluated. The clinical findings (peritonitis, arthritis and pleuritis) were noted. Results: Choroidal thickness was significantly thicker at all measurement points in FMF patients compared to healthy controls during an acute attack (p < 0.05). There were positive correlations between the choroidal thickness and ESR, fibrinogen and, particularly, CRP levels. Clinical findings did not change the choroidal thickness significantly (p > 0.05). Conclusions: Increased choroidal thickness in the acute phase of FMF is possibly related to the inflammatory edematous changes in the choroid.

scholarly journals Macular and choroidal thickness of children with Familial Mediterranean Fever gene mutation

2018 ◽  
pp. 23-28
Author(s):  
Fatih Battal ◽  
Hakan Aylanç ◽  
Şule Yıldırım ◽  
Yeliz Ekim ◽  
Fatma Sılan ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Gene Mutation ◽  
Choroidal Thickness ◽  
Mediterranean Fever

Retinal and Choroidal Thickness in Children with Familial Mediterranean Fever

2014 ◽  
Vol 22 (6) ◽  
pp. 444-448 ◽  
Author(s):  
Mesut Erdurmuş ◽  
Mervan Bekdaş ◽  
Fatih Demircioğlu ◽  
Adem Soydan ◽  
Sevil Bilir Göksügür ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Choroidal Thickness ◽  
Mediterranean Fever

Acute phase response and oxidative stress status in familial Mediterranean fever (FMF)

2012 ◽  
Vol 22 (3) ◽  
pp. 431-437 ◽  
Author(s):  
Savas Guzel ◽  
Gulnur Andican ◽  
Arzu Seven ◽  
Mahmure Aslan ◽  
Murat Bolayirli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Familial Mediterranean Fever ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Oxidative Stress Status ◽  
Mediterranean Fever ◽  
And Oxidative Stress

Familial Mediterranean Fever in Siblings

2012 ◽  
Vol 39 (11) ◽  
pp. 2170-2174
Author(s):  
Z. BIRSIN ÖZÇAKAR ◽  
BEYZA DOGANAY ERDOGAN ◽  
ATILLA H. ELHAN ◽  
FATOŞ YALÇINKAYA
Keyword(s):  
Familial Mediterranean Fever ◽  
Disease Severity ◽  
Acute Phase ◽  
Demographic Data ◽  
Intraclass Correlation ◽  
Age At Onset ◽  
Disease Onset ◽  
Acute Phase Reactant ◽  
Acute Phase Reactants ◽  
Mediterranean Fever

Objective.Genetic and environmental factors have been implicated in disease severity and development of amyloidosis in familial Mediterranean fever (FMF). We investigated similarities in clinical characteristics, disease severity, and treatment response within siblings with FMF.Methods.The study group consisted of 2 or more siblings who were followed in our center with the diagnosis of FMF. Siblings were evaluated for demographic data, clinical and laboratory disease features, genetic analysis of MEFV mutations, and disease severity score. The intraclass correlation coefficient (ICC), which can be interpreted as the expected correlation between 2 siblings, was used to reflect within-family similarity.Results.The study included 67 pediatric patients from 31 different families. When we investigated the similarity of siblings after adjusting for genetic effects, we found very low ICC with p > 0.05 in the majority of clinical features, disease severity, and colchicine dosages. However, age at disease onset, age at onset of therapy, attack-free acute-phase reactant levels, and presence of amyloidosis were found to be similar within siblings (relatively high ICC with p < 0.05).Conclusion.Siblings with FMF had different clinical findings and disease severity. They had similar amyloidogenic potential, proven by both similar presence of amyloid and increased levels of acute-phase reactants between attacks. Our findings strongly support that genetic factors may be more dominant in the development of amyloidosis.

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