Choroidal Thickness Changes in the Acute Attack Period in Patients with Familial Mediterranean Fever

2015 ◽  
Vol 235 (2) ◽  
pp. 72-77 ◽  
Author(s):  
Fatih C. Gundogan ◽  
Fahrettin Akay ◽  
Salih Uzun ◽  
Gokhan Ozge ◽  
Sami Toyran ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Choroidal Thickness ◽  
Serum Levels ◽  
Acute Attack ◽  
Clinical Findings ◽  
Healthy Controls ◽  
Reactive Protein ◽  
Mediterranean Fever ◽  
Acute Attacks ◽  
Positive Correlations

Purpose: The aim of this study was to evaluate choroidal thickness changes during acute attacks of familial Mediterranean fever (FMF). Methods: Fifty patients with FMF and 50 healthy controls were included. Choroidal thickness of each participant was measured at the foveola and horizontal nasal and temporal quadrants at 500-µm intervals to 1,500 µm from the foveola using spectral-domain optical coherence tomography. White blood cell count, erythrocyte sedimentation rate (ESR) and serum levels of fibrinogen and C-reactive protein (CRP) were evaluated. The clinical findings (peritonitis, arthritis and pleuritis) were noted. Results: Choroidal thickness was significantly thicker at all measurement points in FMF patients compared to healthy controls during an acute attack (p < 0.05). There were positive correlations between the choroidal thickness and ESR, fibrinogen and, particularly, CRP levels. Clinical findings did not change the choroidal thickness significantly (p > 0.05). Conclusions: Increased choroidal thickness in the acute phase of FMF is possibly related to the inflammatory edematous changes in the choroid.

Evaluation of Gas6 and sAxl levels during attacks and attack-free periods of familial Mediterranean fever

2018 ◽  
Vol 43 (5) ◽  
pp. 475-480
Author(s):  
Gokhan Cakirca ◽  
Muhammet Murat Celik
Keyword(s):  
Familial Mediterranean Fever ◽  
Specific Protein ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Healthy Control ◽  
Mediterranean Fever

Abstract Objectives: We aimed to assess the growth arrest specific protein 6 (Gas6) and soluble Axl (sAxl) levels in the familial Mediterranean fever (FMF) patients, and to investigate the correlation between the levels of these with the inflammatory markers including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen. Materials and methods: Seventy nine FMF patients (35 in attack period and 44 in attack-free period) and 40 healthy controls were involved in the study. The levels of serum Gas6 and sAxl were measured by enzyme-linked immunosorbent assay (ELISA) method. Results: Gas6 levels of the FMF patients with attack were significantly lower than both the attack-free patients and the healthy controls (p=0.007 and p=0.003, respectively). However, no significant difference was detected between the Gas6 levels of the attack-free patients and the healthy controls (p>0.05). sAxl levels of the FMF patients with attack were significantly lower than the healthy control (p=0.007). A positive correlation was found between the Gas6 and CRP levels of the FMF patients with attack (r=0.379, p=0.025). Conclusions: This study indicates that decreased serum Gas6 and sAxl levels may be associated with FMF attack period. Further studies on the role of the Gas6/Axl system in FMF are needed.

scholarly journals Anti-CCP Antibodies Are Not Associated with Familial Mediterranean Fever in Childhood

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Hatice Onur ◽  
Hale Aral ◽  
Vefik Arica ◽  
Gamze Bercem ◽  
Murat Usta ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
High Specificity ◽  
Study Groups ◽  
Healthy Controls ◽  
Reactive Protein ◽  
Duration Of Illness ◽  
Significant Difference ◽  
Mediterranean Fever ◽  
Antibody Levels ◽  
Citrullinated Peptide

Objective. Anticyclic citrullinated peptide antibodies (anti-CCP) testing is useful in the diagnosis of rheumatoid arthritis (RA) with high specificity. Arthritis is a very common clinical manifestation in children with familial Mediterranean fever (FMF). The aim of the study was to show the presence of anti-CCP antibodies in child individuals diagnosed with FMF.Material and Methods. The study groups comprised one hundred and twenty-six patients (126) diagnosed with FMF (female/male (n): 66/60) and 50 healthy controls (female/male (n): 25/25). Clinical and laboratory assessments of the FMF patients were performed during attack-free periods. Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), fibrinogen, and anti-CCP antibody levels were measured.Results. Anti-CCP was negative in healthy controls and also in all FMF patients. There was not a significant difference in anti-CCP between the patient and the control groups. Our study has shown that anti-CCP was correlated moderately with age (rs=0.271;P=0.0020), duration of illness (rs=0.331;P<0.0001), and colchicine therapy (rs=0.259;P=0.004).Conclusion. Our data show that anti-CCP antibodies are not associated with FMF. Anti-CCP does not have a priority for identifying FMF arthritis from the other inflammatory arthritis.

Association Between Acute Phase Reactants (High Sensitivity C-Reactive Protein and Erythrocyte Sedimentation Rate) and the Genotype of Familial Mediterranean Fever (FMF) in Patients and Healthy Controls

2021 ◽  
Author(s):  
Rami A. Jarjour ◽  
Wafika Zarzour
Keyword(s):  
Familial Mediterranean Fever ◽  
Sedimentation Rate ◽  
High Sensitivity ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Erythrocyte Sedimentation ◽  
M694v Mutation ◽  
Mediterranean Fever ◽  
Hs Crp

Abstract Background: Familial Mediterranean fever (FMF) is an autosomal recessive disorder mainly common in Arabs, Non-Ashkenazi Jews, Armenians and Turks. The classical clinical features include painful attacks and recurrent acute fever with periods of remission. Results: This study was carried out on 101 clinically diagnosed Syrian FMF patients, in addition to 107 apparently healthy controls. Twelve mutations in the gene locus of MEFV were detected using reverse hybridization and the M694V mutation was found to be the most common in Syrian patients. This study showed that there was a statistically significant difference between the two groups when comparing the levels of the high-sensitivity C-reactive protein (hs-CRP) and the erythrocyte sedimentation rate (ESR) for the two groups of patients and healthy controls. However, this study did not show a relationship between genotype of MEFV mutations and hs-CRP titers and ESR in these patients, as well as the absence of a strong relationship between the M694V mutation and hs-CRP titers and ESR. Conclusion: These data indicate the importance of hs-CRP titers and ESR in patients with familial Mediterranean fever when diagnosing the disease, before starting treatment and in attack-free periods, which may give us an idea about the severity of the disease.

scholarly journals Serum Leptin Is not a Diagnostic Marker for Familial Mediterranean Fever Attacks

2006 ◽  
Vol 2006 ◽  
pp. 1-5
Author(s):  
Bülent Toy ◽  
Orhan Tarçın ◽  
Sait Bağcı ◽  
Yücel Üstündağ ◽  
Ali Inal ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Serum Levels ◽  
Control Group ◽  
Serum Leptin ◽  
Reactive Protein ◽  
Mediterranean Fever ◽  
Leukocyte Counts ◽  
The Mean ◽  
Fever Attacks

The aim of our study is to determine whether there is a relationship between familial Mediterranean fever (FMF) attacks and serum leptin levels. We enrolled 25 patients (22 males and 3 females) and 25 healthy controls (21 males and 4 females) with a mean age of24.42±1.22(Mean±SEM) years and24.30±1.19years (Mean±SEM), respectively. We investigated serum levels of leptin, interleukin-6 (IL-6) erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fibrinogen, and leukocyte counts before the attack and 8–12 hours after the attack started. The same parameters have been investigated in the control subjects. The mean serum leptin levels before the attacks were6.45±1.05(Mean±SEM) and during the attacks were7.59±1.3(Mean±SEM) in FMF group, respectively. There was a slight increase in serum leptin levels during the attacks but it was not statistically significant (P>.05). The mean serum leptin levels were6.12±2.81in the control group which were not different from the mean serum leptin levels before and during the attack periods in the study group (P>.05). However, there were statistical differences in the serum levels of IL-6, ESR, CRP, fibrinogen, and leukocyte counts before and during the attack periods (P<.05). No correlation was found between serum leptin levels and IL-6, ESR, CRP, fibrinogen, and leukocyte counts (P>.05). Serum leptin levels do not increase during FMF attacks and therefore it is not useful for diagnostic purposes and follow-up during treatment.

scholarly journals AB1034 DEPRESSION AND ANXIETY IN FAMILIAL MEDITERRANEAN FEVER

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1808.2-1809
Author(s):  
D. Karatas ◽  
Z. Öztürk ◽  
D. Cekic ◽  
Z. Yuertsever ◽  
Ü. Erkorkmaz ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Severe Depression ◽  
Anxiety And Depression ◽  
Control Group ◽  
Healthy Controls ◽  
Depression And Anxiety ◽  
Mild Depression ◽  
Moderate Depression ◽  
Mediterranean Fever

Background:Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease characterized by recurrent attacks of fever, peritonitis, pleuritis, arthritis, and skin eruption (1). It is shown by studies that chronic diseases like diabetes mellitus, chronic heart disease, hypertension which other than inflammatory – rheumatologic disease increase depression and anxiety (2). There are a few studies evaluating depression and anxiety in FMF patients, and these results are conflicting (3,4).Objectives:To assess the frequency of depression and anxiety in patients with Familial Mediterranean Fever (FMF)Methods:In this study, 77 FMF patients aged 18 and over who were followed up in Sakarya University Education and Research Hospital, Department of Rheumatology, and 78 healthy volunteers aged 18 and over as thecontrol group. Beck depression scale and Beck anxiety scale were used to depression and anxiety, respectively. Beck’sdepression scale was evaluated as 9 and below normal, 10-16 mild depression, 17-29 moderate depression, 30-63 severe depression. Beck anxiety scale was evaluated as 0-8 normal, 8-15 mild anxiety, 16-25 moderate anxiety, 26 and above severe anxiety.FMF disease severity was determined by Pras scoring.Results:The study group, comprised 77 diagnosed with FMF with a meanage of 37.18 and a control group comprised of 78 healthy controls (C) with a meanage of 35.32 (p=0,058). İn studygroup (P) %63.6, control group (C) %53.8 as female. %36.4 of thestudy group(C), %46.2 of the control group are male. (p=0,216). The prevalence of depression was significantly higher in FMF patients compared to the control group (in order P;C: normal %24,7; %47,4, mild depression: %40.3; %26.9, moderate depression %26; %19.2, severe depression %11.7; %6.4 p<0.015). Similarly in depression results; the prevalence of anxiety was significantly higher in FMF patients compared to the control group (in order P;C normal %23,4; %57.7, mild anxiety %26; %20.5, moderate anxiety %26; %15.4, severe anxiety %24.4; %6.4 p<0,001). Depression status was not correlated with FMF disease severity (p=0.645). A correlation was found between FMF severity and anxiety which it is which was found statistically significant (p=0.005).There was no relationship between erythrocyte sedimentation rate and C-reactive protein with depression and anxiety.Conclusion:Both anxiety and depression frequency are increased in FMF patients compared to healthy controls.References:[1]Livneh A, Langevitz P, Zemer D et al. (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40 (10), 1879–85.[2]Alonso J, Ferrer M, Gandek B, Ware JE Jr, Aaronson NK, Mosconi P, Rasmussen NK, Bullinger M, Fukuhara S, Kaasa S, Leplège A, IQOLA Project Group (2004) Health-related quality of life associated with chronic conditions in eight countries: results from the International Quality of Life Assessment (IQOLA) Project. Qual Life Res 13:283–298[3]Makay B, Emiroglu N, Unsal E (2010) Depression andanxiety in children and adolescents with familial Mediterranean fever. Clin Rheumatol 29, 375–9.[4]Giese A, Ornek A, Kilic L, Kurucay M, Sendur S. N., Lainka E, Henning B. F. Anxiety and depression in adult patients with familialMediterranean fever: a study comparing patients living in Germany and Turkey. International Journal of Rheumatic Diseases 2017; 20: 2093–2100Disclosure of Interests:None declared

scholarly journals Serum Levels of HCY, MIF, and hs-CRP Correlate with Glycolipid Metabolism in Adults with Never-Medicated First-Episode Schizophrenia

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Xiao Zhong ◽  
Qin Ao ◽  
Fei Xing
Keyword(s):  
Waist Circumference ◽  
Rating Scale ◽  
Serum Levels ◽  
First Episode ◽  
Healthy Controls ◽  
Glycolipid Metabolism ◽  
Hs Crp ◽  
Positive Correlations ◽  
First Episode Schizophrenia ◽  
Negative Syndrome

Objective. It has been reported that the prevalence of metabolic syndrome (MS) in multiepisode patients with schizophrenia is 35.3%, which is 2- to 4-fold higher than in the general population. The study is designed to compare the glycolipid metabolism in patients with first-episode schizophrenia (FES) with sex- and age-matched healthy controls to investigate changes in serum levels of homocysteine (Hcy), macrophage migration inhibitory factor (MIF), and high-sensitive C-reactive protein (hs-CRP) and their relationships with the glycolipid metabolism in patients with FES. Methods. His case-control study included 88 patients diagnosed with FES and 88 sex- and age-matched healthy controls. Patient psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS), and 17-item Hamilton Rating Scale for Depression (HAMD-17). Patients with FES were classified into MS and non-MS groups. Results. There were significant differences in the education level, body mass index (BMI), and waist circumference between the patients with FES and healthy controls (all p > 0.05 ). The patients with FES had higher levels of FPG and blood glucose at the oral glucose tolerance test (OGTT) (2 h glucose) concomitant with higher proportion of impaired glucose tolerance (IGT) and homeostasis model assessment of insulin resistance (HOMA2-IR) than healthy controls (all p < 0.001 ). It was revealed that the patients with FES showed higher serum levels of Hcy, MIF, and hs-CRP than healthy controls (all p < 0.001 ). The serum level of Hcy shared positive correlations with the score of PANSS totals (r = 0.551) and the negative syndrome of the PANSS scale (r = 0.494). The serum levels of MIF and hs-CRP was only positively correlated with the negative syndrome of the PANSS scale (r = 0.320 and r = 0.446). The level of Hcy shared positive correlations with the levels of FPG, 2 h glucose, and HOMA2-IR; the level of MIF was only positively correlated with the level of HOMA2-IR; the level of hs-CRP had a positive correlation with both levels of FPG and 2 h glucose (all p < 0.001 ). The levels of Hcy, MIF, and hs-CRP all shared positive correlations with the TG level and negative correlations with the HDL-C level (all p < 0.001 ). There were remarkable differences between the MS and non-MS groups with regard to BMI, waist circumference, negative subscale of the PANSS scale, FPG, TG, and HDL-C (all p < 0.05 ). Elevated levels of Hcy, MIF, and hs-CRP were detected in the MS group compared to the non-MS group (all p < 0.05 ). Conclusion. These findings suggest that increased concentrations of HCY, MIF, and hs-CRP may contribute to the abnormal glycolipid metabolism in the context of schizophrenia.

scholarly journals Value of immune factors for monitoring risk of lung cancer in patients with interstitial lung disease

2019 ◽  
Vol 47 (7) ◽  
pp. 3344-3353
Author(s):  
Ning Li ◽  
Haisheng Hu ◽  
Ge Wu ◽  
Baoqing Sun
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Serum Levels ◽  
Scaling Analysis ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Reactive Protein ◽  
Increased Risk ◽  
Immune Factors

Objective Patients with interstitial lung disease (ILD) are at increased risk of developing lung cancer. We aimed to investigate the clinical significance of serum immune factors in this progression. Methods We retrospectively screened a hospital database from January 2012 to December 2016 for patients with lung cancer and ILD. We measured serum levels of C3, C4, IgA, IgG, IgM, C-reactive protein (CRP), ceruloplasmin (CER), and rheumatoid factor in these patients and in healthy controls. Results We analyzed data for 262 patients with lung cancer, 220 with ILD, and 57 healthy controls. CER levels were significantly higher in patients with lung cancer (0.35 ± 0.10 g/L) compared with both ILD patients (0.31 ± 0.25 g/L) and healthy individuals (0.25 ± 0.04 g/L). C3 and C4 levels were both significantly higher in healthy individuals compared with patients with lung cancer (C3: 1.70 ± 0.29 vs 1.04 ± 0.26 g/L, C4: 0.27 ± 0.24 vs 0.24 ± 0.09 g/L) and ILD (C3: 1.70 ± 0.29 vs 0.97 ± 0.25 g/L, C4: 0.27 ± 0.24 vs 0.21 ± 0.09 g/L). Optimal scaling analysis demonstrated that lung cancer was closely associated with CRP, CER, C3, and C4. Conclusions Increased levels of CRP and CER and decreased levels of C3 and C4 may identify patients with ILD at high risk of developing lung cancer.

scholarly journals Comparing D-dimer status in children with familial Mediterranean fever during and in between acute attacks

2018 ◽  
Vol 40 (2) ◽  
pp. 107-110 ◽  
Author(s):  
Samia Salah ◽  
Hala Salah Talaat ◽  
Noussa Ragab El Basha ◽  
Huda Marzouk ◽  
Samah Abd Elhamid ◽  
...  
Keyword(s):  
Familial Mediterranean Fever ◽  
Mediterranean Fever ◽  
Acute Attacks ◽  
D Dimer
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