scholarly journals Plasma FGF23 and Calcified Atherosclerotic Plaque in African Americans with Type 2 Diabetes Mellitus

2015 ◽  
Vol 42 (6) ◽  
pp. 391-401 ◽  
Author(s):  
Barry I. Freedman ◽  
Jasmin Divers ◽  
Gregory B. Russell ◽  
Donald W. Bowden ◽  
J. Jeffrey Carr ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
African American ◽  
Coronary Artery ◽  
African Americans ◽  
Kidney Function ◽  
Vascular Calcification ◽  
Atherosclerotic Plaque ◽  
Mineral Density

Background: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone implicated in disorders of serum phosphorus concentration and vitamin D. The role of FGF23 in vascular calcification remains controversial. Methods: Relationships between FGF23 and coronary artery calcified atherosclerotic plaque (CAC), aortoiliac calcified plaque (CP), carotid artery CP, volumetric bone mineral density (vBMD), albuminuria, and estimated glomerular filtration rate (eGFR) were determined in 545 African Americans with type 2 diabetes (T2D) and preserved kidney function in African American-Diabetes Heart Study participants. Generalized linear models were fitted to test associations between FGF23 and cardiovascular, bone, and renal phenotypes, and change in measurements over time, adjusting for age, gender, African ancestry proportion, body mass index, diabetes duration, hemoglobin A1c, blood pressure, renin-angiotensin-system inhibitors, statins, calcium supplements, serum calcium, and serum phosphate. Results: The sample was 56.7% female with a mean (SD) age of 55.6 (9.6) years, diabetes duration of 10.3 (8.2) years, eGFR 90.9 (22.1) ml/min/1.73 m2, urine albumin:creatinine ratio (UACR) 151 (588) (median 13) mg/g, plasma FGF23 161 (157) RU/ml, and CAC 637 (1,179) mg. In fully adjusted models, FGF23 was negatively associated with eGFR (p < 0.0001) and positively associated with UACR (p < 0.0001) and CAC (p = 0.0006), but not with carotid CP or aortic CP. Baseline FGF23 concentration did not associate with changes in vBMD or CAC after a mean of 5.1 years follow-up. Conclusions: Plasma FGF23 concentrations were independently associated with subclinical coronary artery disease, albuminuria, and kidney function in the understudied African American population with T2D. Findings support relationships between FGF23 and vascular calcification, but not between FGF23 and bone mineral density, in African Americans lacking advanced nephropathy.

scholarly journals Relationships between calcified atherosclerotic plaque and bone mineral density in African Americans with type 2 diabetes

2011 ◽  
Vol 26 (7) ◽  
pp. 1554-1560 ◽  
Author(s):  
Jasmin Divers ◽  
Thomas C Register ◽  
Carl D Langefeld ◽  
Lynne E Wagenknecht ◽  
Donald W Bowden ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
African Americans ◽  
Bone Mineral ◽  
Atherosclerotic Plaque ◽  
Mineral Density

scholarly journals Bone Mineral Density and Progression of Subclinical Atherosclerosis in African-Americans With Type 2 Diabetes

2016 ◽  
Vol 101 (11) ◽  
pp. 4135-4141 ◽  
Author(s):  
Lynne E. Wagenknecht ◽  
Jasmin Divers ◽  
Thomas C. Register ◽  
Gregory B. Russell ◽  
Donald W. Bowden ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
African Americans ◽  
Bone Mineral ◽  
Subclinical Atherosclerosis ◽  
Mineral Density

The foot in type 2 diabetes: Is there a link between vascular calcification and bone mineral density?

2011 ◽  
Vol 94 (3) ◽  
pp. 410-416 ◽  
Author(s):  
Dhruv K. Singh ◽  
Peter Winocour ◽  
Bev Summerhayes ◽  
Sunil Kaniyur ◽  
Adie Viljoen ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Vascular Calcification ◽  
Bone Mineral ◽  
Mineral Density

Bone Mineral Density and Fractures in Urban African Americans With Type 2 Diabetes

2014 ◽  
Vol 17 (3) ◽  
pp. 424
Author(s):  
S. Madduri ◽  
S.S. Shenoy ◽  
G.L. Nunlee-Bland ◽  
R. Cherqaoui ◽  
C. Bunton-Young ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
African Americans ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Volumetric bone mineral density of the spine predicts mortality in African-American men with type 2 diabetes

2018 ◽  
Vol 29 (9) ◽  
pp. 2049-2057 ◽  
Author(s):  
L. Lenchik ◽  
T.C. Register ◽  
G.B. Russell ◽  
J. Xu ◽  
S.C. Smith ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
African American ◽  
Bone Mineral ◽  
African American Men ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density

scholarly journals Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: The diabetes heart study

Bone ◽  
2008 ◽  
Vol 42 (1) ◽  
pp. 43-52 ◽  
Author(s):  
J. Jeffrey Carr ◽  
Thomas C. Register ◽  
Fang-Chi Hsu ◽  
Kurt Lohman ◽  
Leon Lenchik ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Mineral ◽  
Atherosclerotic Plaque ◽  
Mineral Density ◽  
Heart Study ◽  
Diabetes Heart Study

Bone mineral density in male patients with type 2 diabetes mellitus, with and without hypogonadism

2017 ◽  
Author(s):  
Agathi Vasileiou ◽  
Ioanna Karathanassi ◽  
Parthena Navrozidou ◽  
Marianna Vlychou ◽  
Georgios Koukoulis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Mineral ◽  
Mineral Density ◽  
Male Patients

Trabecular Bone Score in Thais with or without Type 2 Diabetes

2020 ◽  
Vol 103 (11) ◽  
pp. 1131-1137
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fracture Risk ◽  
Trabecular Bone ◽  
Trabecular Bone Score ◽  
Mineral Density ◽  
Men And Women

Background: When compared to people without type 2 diabetes mellitus (T2DM), people with T2DM have an increase in fracture risk despite having higher bone mineral density (BMD). Many studies in Caucasians demonstrated that trabecular bone score (TBS) is lower in people with T2DM than those without. The utility of TBS as a fracture risk assessment tool in Asians with T2DM is currently unclear. Objective: To compared lumbar spine (LS) BMD and TBS in Thais with or without T2DM and investigate the correlation between TBS and hemoglobin A1c (HbA1c) and diabetes duration in participants with T2DM. Materials and Methods: The present study was a cross-sectional study that included 97 participants with T2DM (37 men and 60 women) and 342 participants without T2DM (174 men and 168 women). LS-BMD and TBS were obtained. Results: Men and women with T2DM were older and had higher body mass index (BMI). Men with T2DM had significant higher LS-BMD (1.051±0.166 versus 0.972±0.125, p=0.009) and non-significant lower TBS (1.333±0.084 versus 1.365±0.096, p=0.055) than those without. Similarly, women with T2DM had significant higher LS-BMD (0.995±0.155 versus 0.949±0.124, p=0.021) and lower TBS (1.292±0.105 versus 1.382±0.096, p<0.001). After adjusting for age and BMI, T2DM predicted higher BMD in men (p<0.001), but not in women (p=0.143). T2DM was not associated with TBS after adjusting for age and BMI in both genders (p=0.403 and p=0.151 in men and women, respectively). TBS did not correlate with HbA1c in both genders. However, TBS was non-significantly associated with diabetes duration in women (p=0.073), but not in men (p=0.639). Conclusion: T2DM significantly predicted higher LS-BMD only in men and was not independently associated with TBS in both genders. These data highlighted that, in T2DM, there was some variation in the clinical usefulness of BMD and TBS in predicting osteoporotic fractures with regard to clinical characteristic of participants. Keywords: Bone mineral density, Type 2 diabetes mellitus, Trabecular bone score

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