Associations of Leu72Met Polymorphism of Preproghrelin with Ratios of Plasma Lipids Are Diversified by a High-Carbohydrate Diet in Healthy Chinese Adolescents

2015 ◽  
Vol 67 (4) ◽  
pp. 236-242
Author(s):  
Mi Su ◽  
Li Qiu ◽  
Qian Wang ◽  
Zhen Jiang ◽  
Xiao Juan Liu ◽  
...  
Keyword(s):  
Plasma Lipids ◽  
Density Lipoprotein ◽  
Chinese Adolescents ◽  
Female Adolescents ◽  
Male And Female ◽  
High Carbohydrate ◽  
Before And After ◽  
Healthy Chinese ◽  
Lipids Profile ◽  
Female Subjects

Background/Aims: The association of preproghrelin Leu72Met polymorphism with plasma lipids profile was inconsistently reported and needs more studies to be confirmed. Our study was to investigate the changes of plasma lipids ratios after a high-carbohydrate (high-CHO) diet in healthy Chinese adolescents with different genotypes of this polymorphism. Methods: Fifty-three healthy university students were given a washout diet of 54.1% carbohydrate for 7 days, followed by a high-CHO diet of 70.1% carbohydrate for 6 days. The anthropometric and biological parameters were analyzed at baseline and before and after the high-CHO diet. Results: When compared with those before the high-CHO diet, body mass index (BMI) decreased in the male and female Met72 allele carriers. Decreased low-/high-density lipoprotein cholesterol (LDL-C/HDL-C) was observed in all participants except the female subjects with the Leu72Leu genotype. TG/HDL-C and log (TG/HDL-C) were increased only in the female subjects with the Leu72Leu genotype. Conclusion: These results suggest that the Met72 allele of preproghrelin Leu72Met polymorphism may be associated with decreased BMI induced by the high-CHO diet in male and female adolescents, while the Leu72 allele with increased TG/HDL-C and log (TG/HDL-C) in the female adolescents only. Furthermore, the decreasing effect of the high-CHO diet on LDL/HDL-C may be eliminated in the female Leu72Leu homozygotes.

scholarly journals The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration

Biomolecules ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 1381
Author(s):  
Gilberto Vargas-Alarcon ◽  
Oscar Perez-Mendez ◽  
Julian Ramirez-Bello ◽  
Rosalinda Posadas-Sanchez ◽  
Hector Gonzalez-Pacheco ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
High Risk ◽  
Gene Polymorphisms ◽  
Plasma Lipids ◽  
Critical Role ◽  
Density Lipoprotein ◽  
Cholesterol Concentration ◽  
Ldlr Gene ◽  
Coronary Syndrome ◽  
Lipids Profile

Dyslipidemia has a substantial role in the development of acute coronary syndrome (ACS). Low-density lipoprotein receptor (LDLR) plays a critical role in plasma lipoprotein hemostasis, which is involved in the formation of atherosclerotic plaque. This study aimed to evaluate whether LDLR gene polymorphisms are significantly associated with ACS and the plasma lipids profile. Three LDLR gene polymorphisms located in the UTR′3 region (c.*52 A/G, c.*504 A/G, and c.* 773 A/G) were determined using TaqMan genotyping assays in a group of 618 ACS patients and 666 healthy controls. Plasma lipids profile concentrations were determined by enzymatic/colorimetric assays. Under co-dominant and recessive models, the c.*52 A allele of the c.*52 A/G polymorphism was associated with a higher risk of ACS (OR = 2.02, pCCo-dom = 0.033, and OR = 2.00, pCRes = 0.009, respectively). In the same way, under co-dominant and recessive models, the c.*773 G allele of the c.*773 A/G polymorphism was associated with a high risk of ACS (OR = 2.04, pCCo-dom = 0.027, and OR = 2.01, pCRes = 0.007, respectively). The “AAG” haplotype was associated with a high risk of ACS (OR = 1.22, pC = 0.016). The c.*52 AA genotype showed a lower HDL-C concentration than individuals with the GG genotype. In addition, carriers of c.*773 GG genotype carriers had a lower concentration of the high-density lipoprotein-cholesterol (HDL-C) than subjects with the AA genotype. Our data suggest the association of the LDLRc.*773 A/G and LDLR c.*52 A/G polymorphisms with both the risk of developing ACS and with a lower concentration of HDL-C in the study population.

scholarly journals Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients

Endocrinology ◽  
2016 ◽  
Vol 157 (4) ◽  
pp. 1421-1429 ◽  
Author(s):  
Amy E. Levenson ◽  
Mary E. Haas ◽  
Ji Miao ◽  
Rebecca J. Brown ◽  
Sarah D. de Ferranti ◽  
...  
Keyword(s):  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Underlying Mechanism ◽  
Male And Female ◽  
Plasma Triglycerides ◽  
Beneficial Effects ◽  
Osmotic Pumps ◽  
Reduced Body

Abstract Leptin treatment has beneficial effects on plasma lipids in patients with lipodystrophy, but the underlying mechanism is unknown. Proprotein convertase subtilisin/kexin type 9 (PCSK9) decreases low-density lipoprotein (LDL) clearance, promotes hypercholesterolemia, and has recently emerged as a novel therapeutic target. To determine the effect of leptin on PCSK9, we treated male and female ob/ob mice with leptin for 4 days via sc osmotic pumps (∼24 μg/d). Leptin reduced body weight and food intake in all mice, but the effects of leptin on plasma PCSK9 and lipids differed markedly between the sexes. In male mice, leptin suppressed PCSK9 but had no effect on plasma triglycerides or cholesterol. In female mice, leptin suppressed plasma triglycerides and cholesterol but had no effect on plasma PCSK9. In parallel, we treated female lipodystrophic patients (8 females, ages 5–23 y) with sc metreleptin injections (∼4.4 mg/d) for 4–6 months. In this case, leptin reduced plasma PCSK9 by 26% (298 ± 109 vs 221 ± 102 ng/mL; n = 8; P = .008), and the change in PCSK9 was correlated with a decrease in LDL cholesterol (r2 = 0.564, P = .03). In summary, in leptin-deficient ob/ob mice, the effects of leptin on PCSK9 and plasma lipids appeared to be independent of one another and strongly modified by sex. On the other hand, in lipodystrophic females, leptin treatment reduced plasma PCSK9 in parallel with LDL cholesterol.

scholarly journals Assessment of Anxiety Levels In Male and Female Adolescents

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Vandana Patel ◽  
Anil Jain
Keyword(s):  
Anxiety Scale ◽  
Female Adolescents ◽  
Male Adolescent ◽  
Male And Female ◽  
Fast Change ◽  
Anxiety Levels ◽  
Female Subjects

Background: Adolescence is a period of fast change incorporating physical, mental, social and passionate domain. Mainstream share of teenagers encounter dissatisfaction and perplexity in taking choice while going through youth to adulthood. The present study was planned to assess the level of Anxiety among Male and Female Adolescents. Materials and Methods: The sample consisted of 30 adolescents. The number of male and female subjects was 15 each. The age of subjects ranged from 12-18 years. For the measurement of anxiety levels of the adolescents, Teat anxiety scale given by Dr. VP Sharma in 1971 was employed. Results: Mean anxiety scores of males were higher as compared to females. The level of anxiety in male adolescent subjects was observed to be higher than female subjects due to over monitored life, accommodation because of socialization design, mildness, and sentiment rivalry in each work and Confusion in taking choices. Conclusion: We conclude that the level of anxiety in male adolescent subjects is higher than female subjects.

scholarly journals Effects of 8-week zumba exercise on blood lipids profile in sedentary women

2021 ◽  
Vol 25 (3) ◽  
pp. 172-177
Author(s):  
Mine Turgut ◽  
Yusuf Soylu
Keyword(s):  
Blood Lipids ◽  
Low Density Lipoprotein ◽  
Exercise Program ◽  
Density Lipoprotein ◽  
Health Behaviours ◽  
Lipoprotein Cholesterol ◽  
Before And After ◽  
Post Test ◽  
Lipids Profile ◽  
Sedentary Women

Background and Study Aim. Different aerobic exercise may affect women’s health behaviours. Therefore, this study aimed to determine the effect of 8-week Zumba exercises applied to sedentary women on lipid profile. Material and Methods. Fifty voluntary healthy sedentary women with a mean age of 32.1 ± 6.8 years and a mean height of 158.4 ± 15.5 cm participated in the study. Before and after the exercise program, blood samples and body weight were taken on before breakfast in the morning by experts in the appropriate laboratory environment, some environmental measurements. In the analysis of the data, the SPSS 22.0 package program was used to compare the pre-post exercise values (Paired Sample T-Test) as well as descriptive statistics. The effect sizes (Cohen's d) were calculated to provide the estimation of the comparisons between the pre-test and post-test results of the obtained values. Results. According to the results, it was determined that there were significant differences between blood lipids Glucose, Urea, Triglyceride, total High-Density Lipoprotein Cholesterol (HDL-C) and Low-Density Lipoprotein Cholesterol (LDL-C) levels before and after Zumba exercise program (p <0.05). In addition, it was determined that there was a significant and positive change between the pre-test and post-test BMI values (p <0.05). Conclusions. According to the results of the study, it was concluded that the 8-week Zumba exercise program applied to sedentary women had a positive effect on the lipid profiles of women.

scholarly journals Omega-3 fatty acid supplementation in primary nephrotic syndrome: effects on plasma lipids and coagulopathy.

1992 ◽  
Vol 3 (6) ◽  
pp. 1321-1329
Author(s):  
A V Hall ◽  
A Parbtani ◽  
W F Clark ◽  
E Spanner ◽  
M W Huff ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Platelet Aggregation ◽  
Fish Oil ◽  
Bleeding Time ◽  
Plasma Lipids ◽  
Low Density Lipoprotein ◽  
Urine Volume ◽  
Density Lipoprotein ◽  
Low Density ◽  
Before And After

The effect of fish oil dietary supplementation on the dyslipidemia and coagulopathy of seven patients with nephrotic syndrome and hypoalbuminemia due to primary kidney disease was studied. Plasma lipids, platelet aggregation studies, simplate bleeding time, and fibrinogen levels were determined before and after 6 wk of treatment with fish oil (15 g/day of MaxEPA; 2.7 g of eicosapentenoic acid (EPA) and 1.8 g of docosahexenoic acid. Urea kinetics were determined from urine-urea concentration, urinary proteina, and urine volume. A 3-day dietary intake record was obtained from each patient before and after 6 wk of fish oil supplementation. There was no significant dietary change in protein, fat, or carbohydrate intake over the time period of the study. At study end, total triglycerides decreased from 2.98 +/- 1.31 to 2.18 +/- 1.14 mmol/L (P = 0.002), and very low-density lipoprotein-triglycerides decreased from 2.35 +/- 1.34 to 1.28 +/- 1.07 mmol/L (P = 0.01). Low-density lipoprotein (LDL) cholesterol increased from 5.18 +/- 1.74 to 7.35 +/- 2.83 mmol/L (P = 0.005). No significant changes occurred in bleeding time, platelet count, hematocrit, red blood cell flexibility, or whole blood viscosity. Platelet aggregation responses to collagen and arachidonic acid were consistently reduced after treatment, but there was no change in platelet response to ADP. The platelet membrane phospolipids showed a significantly increased incorporation of EPA after the fish oil diet (P = 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)

The Clinical, Roentgenological and Morphological Effects of an Acute Exposure of Phosgene on the Lungs of Dogs

1971 ◽  
Vol 29 ◽  
pp. 236-237
Author(s):  
R. F. Bils ◽  
W. F. Diller ◽  
F. Huth
Keyword(s):  
Latent Period ◽  
Chemical Industry ◽  
Toxic Substance ◽  
Lung Edema ◽  
X Rays ◽  
Beagle Dogs ◽  
Male And Female ◽  
Morphological Alterations ◽  
Before And After ◽  
Electron Microscopes

Phosgene still plays an important role as a toxic substance in the chemical industry. Thiess (1968) recently reported observations on numerous cases of phosgene poisoning. A serious difficulty in the clinical handling of phosgene poisoning cases is a relatively long latent period, up to 12 hours, with no obvious signs of severity. At about 12 hours heavy lung edema appears suddenly, however changes can be seen in routine X-rays taken after only a few hours' exposure (Diller et al., 1969). This study was undertaken to correlate these early changes seen by the roengenologist with morphological alterations in the lungs seen in the'light and electron microscopes.Forty-two adult male and female Beagle dogs were selected for these exposure experiments. Treated animals were exposed to 94.5-107-5 ppm phosgene for 10 min. in a 15 m3 chamber. Roentgenograms were made of the thorax of each animal before and after exposure, up to 24 hrs.

A Tape Striation Counting Method for Determining Fundamental Frequency

1979 ◽  
Vol 10 (4) ◽  
pp. 246-248 ◽  
Author(s):  
Peter B. Mueller ◽  
Marla Adams ◽  
Jean Baehr-Rouse ◽  
Debbie Boos
Keyword(s):  
Fundamental Frequency ◽  
Counting Method ◽  
Male And Female ◽  
Fundamental Frequencies ◽  
Counting Procedure ◽  
Female Subjects

Mean fundamental frequencies of male and female subjects obtained with FLORIDA I and a tape striation counting procedure were compared. The fundamental frequencies obtained with these two methods were similar and it appears that the tape striation counting procedure is a viable, simple, and inexpensive alternative to more costly and complicated procedures and instrumentation.

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