scholarly journals Hemiparetic Primary Lateral Sclerosis: Revisiting Mills Syndrome

2013 ◽  
Vol 7 (3) ◽  
pp. 191-195 ◽  
Author(s):  
Nicholas J. Maragakis ◽  
Neil R. Holland ◽  
Andrea M. Corse
Keyword(s):  
Corticospinal Tract ◽  
Clinical Presentation ◽  
Primary Lateral Sclerosis ◽  
Primary Lateral ◽  
Lateral Sclerosis ◽  
Mills Syndrome

A slowly progressive hemiparesis beginning in a single limb with evolution to the ipsilateral limb was originally described in 8 patients in 1906 by Mills. We present 5 cases of progressive hemiparetic corticospinal tract degeneration, identified by the clinical presentation and the exclusion of other etiologies using serological, imaging, and electrodiagnostic studies.

scholarly journals Mills’ syndrome: a case report

2009 ◽  
Vol 1 (1) ◽  
pp. 15 ◽  
Author(s):  
Fábio Henrique De Gobbi Porto ◽  
Marco Orsini ◽  
Marco Antônio Araújo Leite ◽  
José Moreira dos Santos ◽  
Soraia Pulier ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Clinical Presentation ◽  
Sensory Impairment ◽  
Primary Lateral Sclerosis ◽  
Diagnosis And Prognosis ◽  
One Year ◽  
Primary Lateral ◽  
Lateral Sclerosis ◽  
Mills Syndrome

The syndrome of progressive, ascending or descending hemiplegia, with no significant sensory impairment was first describes by Mills in 1900, which several cases were reported later. However after diagnostic tests and image improvements, the number of reports has shortened. A possible explanation for this shortage is the identification of other diseases that could mimic the clinical picture. Currently, the syndrome has an uncertain nosological status, since it was described based on clinical examination only. We can find this clinical presentation (Mills syndrome) in cases of amyotrophic lateral sclerosis (ALS), predominant upper motor neuron amyotrophic lateral sclerosis (UMN-ALS) and primary lateral sclerosis (PLS), besides its symptomatic (secondary) forms. We describe a case (initial presentation and one year follow-up) of progressive ascending hemiplegia with clinical isolated upper neuron signs and normal sensory examination, discussing its nosological status, electromyographic findings, differential diagnosis and prognosis.

Mills' syndrome. A clinical case of a rare degenerative pathology of the central nervous system

2020 ◽  
pp. 57-60
Author(s):  
Konstantin Gulyabin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neurological Diseases ◽  
Cortical Atrophy ◽  
Primary Lateral Sclerosis ◽  
System A ◽  
The Central Nervous System ◽  
Primary Lateral ◽  
Lateral Sclerosis ◽  
Mills Syndrome

Mills' syndrome is a rare neurological disorder. Its nosological nature is currently not completely determined. Nevertheless, Mills' syndrome is considered to be a rare variant of the degenerative pathology of the central nervous system – a variant of focal cortical atrophy. The true prevalence of this pathology is unknown, since this condition is more often of a syndrome type, observed in the clinical picture of a number of neurological diseases (primary lateral sclerosis, frontotemporal dementia, etc.) and is less common in isolated form.

scholarly journals Permanent lesion to the corticospinal tract after therapy with capecitabine

2019 ◽  
Vol 12 (9) ◽  
pp. e231248 ◽  
Author(s):  
Tobias A Wagner-Altendorf ◽  
Marcus Heldmann ◽  
Henrike Hanssen ◽  
Thomas F Münte
Keyword(s):  
Breast Cancer ◽  
Aspiration Pneumonia ◽  
Side Effect ◽  
Corticospinal Tract ◽  
Solid Tumours ◽  
Bilateral Lesion ◽  
Severe Side Effect ◽  
Primary Lateral Sclerosis ◽  
Primary Lateral ◽  
Lateral Sclerosis

Capecitabine is an oral fluoropyrimidine used to treat solid tumours such as colorectal and breast cancer. A rare but severe side effect is capecitabine-induced leukoencephalopathy, including bilateral lesion to the corticospinal tract. However, neurological symptoms due to capecitabine treatment are usually reported to be reversible after discontinuation of capecitabine. Here, we present the case of a patient with bilateral degeneration of the corticospinal tract and progressive spastic tetraplegia after chemotherapy with capecitabine mimicking primary lateral sclerosis. Although therapy with capecitabine was ended, symptoms substantially worsened over the following years and the patient finally died from aspiration pneumonia almost 3 years after the application of capecitabine.

scholarly journals Neuroimaging in primary lateral sclerosis

2020 ◽  
Vol 21 (sup1) ◽  
pp. 18-27
Author(s):  
Erik P. Pioro ◽  
Martin R. Turner ◽  
Peter Bede
Keyword(s):  
Primary Lateral Sclerosis ◽  
Primary Lateral ◽  
Lateral Sclerosis

Extra-motor cerebral changes and manifestations in primary lateral sclerosis

2021 ◽  
Author(s):  
Eoin Finegan ◽  
Stacey Li Hi Shing ◽  
Rangariroyashe H. Chipika ◽  
Kai Ming Chang ◽  
Mary Clare McKenna ◽  
...  
Keyword(s):  
Primary Lateral Sclerosis ◽  
Primary Lateral ◽  
Lateral Sclerosis

Loss ofERLIN2function leads to juvenile primary lateral sclerosis

2012 ◽  
Vol 72 (4) ◽  
pp. 510-516 ◽  
Author(s):  
Amr Al-Saif ◽  
Saeed Bohlega ◽  
Futwan Al-Mohanna
Keyword(s):  
Primary Lateral Sclerosis ◽  
Primary Lateral ◽  
Lateral Sclerosis

scholarly journals Genetics of primary lateral sclerosis

2020 ◽  
Vol 21 (sup1) ◽  
pp. 28-34
Author(s):  
Vincenzo Silani ◽  
Philippe Corcia ◽  
Matthew B. Harms ◽  
Guy Rouleau ◽  
Teepu Siddique ◽  
...  
Keyword(s):  
Primary Lateral Sclerosis ◽  
Primary Lateral ◽  
Lateral Sclerosis
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