Sehbehinderung und Hüftfrakturen: Eine Fall-Kontroll-Studie bei älteren Patienten

2015 ◽  
Vol 1 (2) ◽  
pp. 92-93
Keyword(s):  
Elderly Patients ◽  
Visual Impairment ◽  
Hip Fractures ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Control Study ◽  
Klinische Beurteilung

Ziele: Untersuchung des Zusammenhangs zwischen Sehbehinderung und sturzbedingten Hüftfrakturen und Bestimmung der Ätiologie der Sehbehinderung bei einer Population älterer Patienten mit Hüftfrakturen. Methoden: In einer Fall-Kontroll-Studie wurden 96 Patienten mit diagnostizierter Hüftfraktur mit einer zufällig ausgewählten Kontrollgruppe von 103 Patienten ohne Hüftfraktur verglichen. Die Einschlusskriterien für die Fallgruppe waren ein Lebensalter von ≥60 Jahren und eine Hüftfraktur. Die klinische Beurteilung umfasste einen Sehtest und eine augenärztliche Untersuchung. Ergebnisse: 43 Patienten mit Hüftfraktur hatten eine Sehbehinderung, verglichen mit nur 12 Patienten in der Kontrollgruppe. Eine Sehbehinderung stellte einen signifikanten Risikofaktor für eine Hüftfraktur dar (Odds Ratio (OR) 6,15; 95%-Konfidenzintervall (KI) 2,98-12,69). Bei 27 Patienten mit Hüftfraktur lag eine unkorrigierte Fehlsichtigkeit vor; bei den Kontrollprobanden waren es 15 (OR 2,78; 95%-KI 0,92-8,35). Im Hinblick auf dichte Katarakt bestand kein signifikanter Unterschied zwischen den beiden Gruppen (OR 2,28; 95%-KI 0,75-6,93). Bei 14 Hüftfraktur-Patienten lag eine Makuladegeneration vor, im Vergleich zu nur 8 Kontrollpatienten (OR 5,63; 95%-KI 1,57-20,18), und bei 10 Patienten bestand der Verdacht auf Glaukom, verglichen mit nur 5 Kontrollen (OR 10,65; 95%-KI 2,21-51,3). Schlussfolgerung: Das Vorliegen einer Sehbehinderung war bei älteren Menschen signifikant mit einem erhöhten Risiko für Hüftfrakturen assoziiert. Viele verschiedene Ätiologien können auf diese Weise zu Hüftfrakturen beitragen, insbesondere Fehlsichtigkeit, Katarakt, Makuladegeneration und Glaukom. Übersetzung aus Loriaut P, et al: Visual impairment and hip fractures: a case-control study in elderly patients. Ophthalmic Res 2014;52:212-216 (DOI: 10.1159/000362881)

Visual Impairment and Hip Fractures: A Case-Control Study in Elderly Patients

2014 ◽  
Vol 52 (4) ◽  
pp. 212-216 ◽  
Author(s):  
Patrick Loriaut ◽  
Philippe Loriaut ◽  
Patrick Boyer ◽  
Philippe Massin ◽  
Isabelle Cochereau
Keyword(s):  
Elderly Patients ◽  
Visual Impairment ◽  
Hip Fractures ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals Two-year changes in quality of life in elderly patients with low-energy hip fractures. A case-control study

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Gudrun Rohde ◽  
Glenn Haugeberg ◽  
Anne Marit Mengshoel ◽  
Torbjorn Moum ◽  
Astrid K Wahl
Keyword(s):  
Quality Of Life ◽  
Elderly Patients ◽  
Hip Fractures ◽  
Case Control Study ◽  
Case Control ◽  
Low Energy ◽  
Control Study

scholarly journals A case–control study in France showing that a pro-inflammatory diet is associated with a higher risk of breast cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mariem Hajji-Louati ◽  
Emilie Cordina-Duverger ◽  
Nasser Laouali ◽  
Francesca-Romana Mancini ◽  
Pascal Guénel
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Odds Ratio ◽  
Hormone Receptors ◽  
Case Control Study ◽  
Breast Cancer Subtype ◽  
Case Control ◽  
Tumor Subtype ◽  
Control Study

AbstractDietary regimens promoting inflammatory conditions have been implicated in breast cancer development, but studies on the association between pro-inflammatory diet and breast cancer risk have reported inconsistent results. We investigated the association between the inflammatory potential of diet and breast cancer risk in a case–control study in France including 872 breast cancer cases and 966 population controls. All women completed a food frequency questionnaire that was used to compute a Dietary Inflammatory Index (DII) based on the inflammatory weight of 33 dietary components. The DII ranged from a median of − 3.22 in the lowest quartile (anti-inflammatory) to + 2.96 in the highest quartile (pro-inflammatory). The odds ratio contrasting quartile 4 to quartile 1 was 1.31 (95% CI 1.00, 1.73; p-trend = 0.02). Slightly higher odds ratios were observed in post-menopausal women, particularly those with body mass index > 25 kg/m2 (odds ratio 1.62; 95% CI 0.92, 2.83; p-trend = 0.02), and among ever smokers (odds ratio 1.71; 95% CI 1.11, 2.65; p-trend 0.01). The analyses by breast cancer subtype showed that the DII was associated with breast tumors that expressed either the estrogen (ER) or progesterone (PR) hormone receptors or the Human Epidermal Growth Factor Receptor-2 (HER2), but no association was seen for the triple negative breast tumor subtype. Our results add further evidence that a pro-inflammatory diet is associated with breast cancer risk with possible effect variation according to tumor subtype.

scholarly journals Plasma acylcarnitines and risk of lower-extremity functional impairment in older adults: a nested case–control study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Francisco Félix Caballero ◽  
Ellen A. Struijk ◽  
Alberto Lana ◽  
Antonio Buño ◽  
Fernando Rodríguez-Artalejo ◽  
...  
Keyword(s):  
Older Adults ◽  
Confidence Interval ◽  
Lower Extremity ◽  
Functional Impairment ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Community Dwelling ◽  
Control Study ◽  
Long Chain

AbstractElevated concentrations of acylcarnitines have been associated with higher risk of obesity, type 2 diabetes and cardiovascular disease. The aim of the present study was to assess the association between L-carnitine and acylcarnitine profiles, and 2-year risk of incident lower-extremity functional impairment (LEFI). This case–control study is nested in the Seniors-ENRICA cohort of community-dwelling older adults, which included 43 incident cases of LEFI and 86 age- and sex- matched controls. LEFI was assessed with the Short Physical Performance Battery. Plasma L-carnitine and 28 acylcarnitine species were measured. After adjusting for potential confounders, medium-chain acylcarnitines levels were associated with 2-year incidence of LEFI [odds ratio per 1-SD increase: 1.69; 95% confidence interval: 1.08, 2.64; p = 0.02]. Similar results were observed for long-chain acylcarnitines [odds ratio per 1-SD increase: 1.70; 95% confidence interval: 1.03, 2.80; p = 0.04]. Stratified analyses showed a stronger association between medium- and long-chain acylcarnitines and incidence of LEFI among those with body mass index and energy intake below the median value. In conclusion, higher plasma concentrations of medium- and long-chain acylcarnitines were associated with higher risk of LEFI. Given the role of these molecules on mitochondrial transport of fatty acids, our results suggest that bioenergetics dysbalance contributes to LEFI.

scholarly journals Parental risk factors for congenital diaphragmatic hernia – a large German case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Felicitas Schulz ◽  
Ekkehart Jenetzky ◽  
Nadine Zwink ◽  
Charlotte Bendixen ◽  
Florian Kipfmueller ◽  
...  
Keyword(s):  
Risk Factors ◽  
Confidence Interval ◽  
Environmental Risk ◽  
Odds Ratio ◽  
Alcohol Intake ◽  
Case Control Study ◽  
Case Control ◽  
Parental Risk Factors ◽  
Healthy Control ◽  
Control Study

Abstract Background Evidence for periconceptional or prenatal environmental risk factors for the development of congenital diaphragmatic hernia (CDH) is still scarce. Here, in a case-control study we investigated potential environmental risk factors in 199 CDH patients compared to 597 healthy control newborns. Methods The following data was collected: time of conception and birth, maternal BMI, parental risk factors such as smoking, alcohol or drug intake, use of hairspray, contact to animals and parental chronic diseases. CDH patients were born between 2001 and 2019, all healthy control newborns were born in 2011. Patients and control newborns were matched in the ratio of three to one. Results Presence of CDH was significantly associated with maternal periconceptional alcohol intake (odds ratio = 1.639, 95% confidence interval 1.101–2.440, p = 0.015) and maternal periconceptional use of hairspray (odds ratio = 2.072, 95% confidence interval 1.330–3.229, p = 0.001). Conclusion Our study suggests an association between CDH and periconceptional maternal alcohol intake and periconceptional maternal use of hairspray. Besides the identification of novel and confirmation of previously described parental risk factors, our study underlines the multifactorial background of isolated CDH.

Feasibility of esophagectomy for esophageal cancer in elderly patients: a case–control study

2021 ◽  
Author(s):  
Nobuhiro Tsuchiya ◽  
Chikara Kunisaki ◽  
Sho Sato ◽  
Yusaku Tanaka ◽  
Kei Sato ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Elderly Patients ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals 744. Effectiveness of 23-Valent Pneumococcal Polysaccharide Vaccine and Influenza Vaccine Against Pneumococcal Pneumonia Among Elderly Patients Aged 65 Years and Older in the Republic of Korea: A Case–Control Study

2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S267-S267
Author(s):  
Jong Hun Kim ◽  
Byung Chul Chun ◽  
Joon Young Song ◽  
Hyo Youl Kim ◽  
In-Gyu Bae ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Elderly Population ◽  
Case Control Study ◽  
The Elderly ◽  
Case Control ◽  
Polysaccharide Vaccine ◽  
Vaccine Effectiveness ◽  
Pneumococcal Polysaccharide Vaccine ◽  
The Republic ◽  
Control Study

Abstract Background The national immunization program (NIP) of annual influenza vaccination to the elderly population (≥65 years of age) in the Republic of Korea (ROK) has been implemented since 1987. Recently, the 23-valent pneumococcal polysaccharide vaccine (PPV23) through the NIP has been provided to the elderly population in the ROK since May 2013. The aim of this study was to assess PPV23 and influenza vaccine (IV) effectiveness in preventing pneumococcal pneumonia (PP) among elderly patients ≥65 years of age. Methods A case–control study using a hospital-based cohort was conducted. Cases of PP including bacteremic PP and nonbacteremic PP were collected from 14 hospitals in the pneumococcal diseases surveillance program from March 2013 to October 2015. Controls matched by age and sex in the same hospital were selected. Demographic, clinical information, and vaccination histories were collected. Previous immunization was categorized into “vaccinated” if a patient had received vaccines as follows: PPV23 (4 weeks to 5 years) and IV (2 weeks to 6 months) prior to the diagnosis of PP for case patients and prior to the hospital admission for control patients. Adjusted odds ratio (OR) was calculated, controlling for underlying medical conditions. Vaccine effectiveness was defined as (1 – OR) × 100. Results During the study period, a total of 661 cases (104 bacteremic PP cases and 557 nonbacteremic PP cases) and 661 controls were enrolled for analyses. For overall patients ≥65 years of age, there was no significant vaccine effectiveness against PP. For young elderly patients with 65–74 years, IV alone (1.2%, [95% confidence interval (CI) −95.3% to 50.0%]) and PPV23 alone (21.9%, [95% CI −39.0% to 56.1%]) were not effective. However, significant vaccine effectiveness of PPV23 plus IV against PP was noted (54.4%, [95% CI 6.9–77.7%], P = 0.031). For older elderly patients ≥75 years of age, no significant vaccine effectiveness was observed. Conclusion Our study indicates that PPV23 plus IV may be effective in preventing PP among young elderly patients with 65–74 years, suggesting additive benefits of influenza plus PPV23 vaccination. Further studies are required to confirm the persistent additive protective effectiveness. Disclosures All authors: No reported disclosures.

scholarly journals Associations between Red Blood Cell and Platelet Transfusions and Retinopathy of Prematurity

Neonatology ◽  
2020 ◽  
pp. 1-7
Author(s):  
Tobias Hengartner ◽  
Mark Adams ◽  
Riccardo E. Pfister ◽  
Diane Snyers ◽  
Jane McDougall ◽  
...  
Keyword(s):  
Retinopathy Of Prematurity ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Same Sex ◽  
Live Births ◽  
Adjusted Logistic Regression ◽  
Control Study

<b><i>Aim:</i></b> The aim of this study is to examine possible associations between the transfusion of RBC or platelets (PLTs) and the development of retinopathy of prematurity (ROP) in infants. <b><i>Methods:</i></b> This retrospective, national, case-control study included all live births in Switzerland between 2013 and 2018. We investigated preterm infants at a gestational age of &#x3c;28 weeks, who developed higher stage ROP (≥stage 2, <i>n</i> = 178). Each case infant was matched to another of the same sex who did not develop ROP (<i>n</i> = 178, control group). <b><i>Results:</i></b> When compared with the control group, we observed higher numbers of RBC transfusions per infant and higher percentages of infants receiving PLT transfusions in the case group. An adjusted logistic regression analysis revealed that both RBC (odds ratio [OR] 1.081, 95% confidence interval [CI] 1.020–1.146) and PLT transfusions (OR = 2.502, 95% CI 1.566–3.998) numbers were associated with ROP development. <b><i>Conclusions:</i></b> Multiple RBC and PLT transfusions are associated with higher stage ROP development. Prospective studies are required to determine their potential as risk factors.

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