Serum Amyloid A-Positive Hepatocellular Neoplasm: A New Type of Tumor Arising in Patients with Advanced Alcoholic Disease

2015 ◽  
Vol 33 (5) ◽  
pp. 648-654 ◽  
Author(s):  
Motoko Sasaki ◽  
Yasuni Nakanuma
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Serum Amyloid A ◽  
Hepatocellular Adenoma ◽  
Clinicopathological Features ◽  
Serum Amyloid ◽  
Amyloid A ◽  
New Type ◽  
Strong Immunoreactivity ◽  
Alcoholic Disease

This chapter reviews a new type of hepatocellular neoplasm, serum amyloid A-positive hepatocellular neoplasm (SAA-HN), which arises in patients with advanced alcoholic liver disease such as cirrhosis. SAA-HNs share histological and immunohistochemical features with inflammatory hepatocellular adenoma, for example, a strong immunoreactivity for SAA. Clinicopathological features and issues regarding SAA-HN are reviewed with emphasis regarding its potential to develop into hepatocellular carcinoma.

scholarly journals Familial Mediterranean Fever: an unusual cause of liver disease

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
Maria Cristina Maggio ◽  
Maria Castiglia ◽  
Giovanni Corsello
Keyword(s):  
Abdominal Pain ◽  
Liver Disease ◽  
Familial Mediterranean Fever ◽  
Serum Amyloid A ◽  
Mefv Gene ◽  
Serum Amyloid ◽  
Aphthous Stomatitis ◽  
Homozygous Mutation ◽  
Amyloid A ◽  
Mediterranean Fever

Abstract Background Familial Mediterranean Fever is an autoinflammatory disease typically expressed with recurrent attacks of fever, serositis, aphthous stomatitis, rash. Only a few reports describe the association with hepatic involvement. Case presentation We describe the clinical case of a child affected, since the age of 1 year, by recurrent fever, aphthous stomatitis, rash, arthralgia, associated with abdominal pain, vomiting, lymphadenopathy. The diagnosis of Familial Mediterranean Fever was confirmed by the genetic study of MEFV gene; the homozygous mutation M694 V in exon was documented. A partial control of attacks was obtained with colchicine. The child continued to manifest only recurrent episodes of abdominal pain without fever, however serum amyloid A persisted high, in association with enhanced levels of CRP, AST and ALT (1.5 x n.v.). The dosage of colchicine was increased step by step and the patient achieved a better control of symptoms and biochemical parameters. However, the patient frequently needed an increase in the dose of colchicine, suggesting the possible usefulness of anti-interleukin-1 beta treatment. Conclusions The unusual presentation of Familial Mediterranean Fever with liver disease suggests the role of inflammasome in hepatic inflammation. Colchicine controls systemic inflammation in most of the patients; however, subclinical inflammation can persist in some of them and can manifest with increased levels of CRP, ESR, serum amyloid A also in attack-free intervals.

scholarly journals Serum Amyloid A is a Novel Prognostic Biomarker in Hepatocellular Carcinoma

2015 ◽  
Vol 15 (24) ◽  
pp. 10713-10718 ◽  
Author(s):  
Xiao-Chun Ni ◽  
Yong Yi ◽  
Yi-Peng Fu ◽  
Hong-Wei He ◽  
Xiao-Yan Cai ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Serum Amyloid A ◽  
Prognostic Biomarker ◽  
Serum Amyloid ◽  
Amyloid A

scholarly journals Overview of Hepatocellular Adenoma in Japan

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Motoko Sasaki ◽  
Yasuni Nakanuma
Keyword(s):  
Oral Contraceptives ◽  
Hepatocellular Adenoma ◽  
Alcoholic Cirrhosis ◽  
Hepatocyte Nuclear Factor ◽  
Asian Countries ◽  
Genetic Changes ◽  
Amyloid A ◽  
Phenotype Classification ◽  
New Type ◽  
Strong Immunoreactivity

Hepatocellular adenoma (HCA) is generally a benign hepatocellular tumor arising in a nonfibrotic/cirrhotic liver, and recently four major subgroups were identified based on genotype and phenotype classification from Europe. HCA is rare in Asian countries including Japan, and there have been few studies regarding the subgroups of HCA in Japan. We surveyed subgroups of HCA in 13 patients (7 women) in Japan, based on the phenotypic classification. As results, we identified 2 hepatocyte nuclear factor (HNF) 1α-inactivated HCAs (15%), twoβ-catenin-activated HCAs (15%), 5 inflammatory HCAs (39%), and 4 unclassified HCAs (29%). The use of oral contraceptives was found only in 2 unclassified HCAs (29%). Rather low percentage of female patients and use of oral contraceptives appear to be common clinicopathological features in Japan and also East Asian countries. Furthermore, a group of possible inflammatory HCAs characterized by strong immunoreactivity for serum amyloid A (SAA) was found in patients with alcoholic cirrhosis. The inflammatory HCA/SAA-positive hepatocellular neoplasm in alcoholic cirrhosis may be a new entity of HCA, which may have potential of malignant transformation. Further studies are needed to clarify genetic changes, monoclonality, and pathogenesis of this new type of hepatocellular neoplasm.

scholarly journals Contrast-enhanced ultrasonographic findings of serum amyloid A-positive hepatocellular neoplasm: Does hepatocellular adenoma arise in cirrhotic liver?

2016 ◽  
Vol 8 (26) ◽  
pp. 1110 ◽  
Author(s):  
Mariko Kumagawa ◽  
Naoki Matsumoto ◽  
Yukinobu Watanabe ◽  
Midori Hirayama ◽  
Takao Miura ◽  
...  
Keyword(s):  
Serum Amyloid A ◽  
Hepatocellular Adenoma ◽  
Cirrhotic Liver ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Contrast Enhanced

Serum Amyloid A in Healthy Female Bottlenose Dolphins (Tursiops truncatus) During and After Uncomplicated Pregnancy

2017 ◽  
Vol 43 (4) ◽  
pp. 417-420 ◽  
Author(s):  
Sarah N. Miller ◽  
Michelle Davis ◽  
Jorge A. Hernandez ◽  
Judy St. Leger ◽  
Carolyn Cray ◽  
...  
Keyword(s):  
Tursiops Truncatus ◽  
Serum Amyloid A ◽  
Bottlenose Dolphins ◽  
Serum Amyloid ◽  
Amyloid A ◽  
Uncomplicated Pregnancy ◽  
Healthy Female
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