scholarly journals Metastatic Fibrolamellar Hepatocellular Carcinoma to the Pancreas

2015 ◽  
Vol 9 (2) ◽  
pp. 266-271 ◽  
Author(s):  
Nicolas A. Villa ◽  
Rahul Pannala ◽  
Douglas O. Faigel ◽  
Danielle J. Haakinson ◽  
Nitin Katariya ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Lymph Nodes ◽  
Primary Resection ◽  
High Rate ◽  
Fibrolamellar Hepatocellular Carcinoma ◽  
Regional Lymph Nodes ◽  
Underlying Liver Disease ◽  
Liver Recurrence ◽  
Resected Liver

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare variant of hepatocellular carcinoma, usually presenting in the younger population (<40 years) without underlying liver disease. Although it has a better prognosis than hepatocellular carcinoma, it has a high rate of recurrence months to years after primary resection. While sites of recurrence usually involve the liver, regional lymph nodes, peritoneum, and lung, metastasis to the pancreas is extremely rare, with only 2 other cases reported in the literature. We present the case of a 46-year-old patient with metastatic FL-HCC to the pancreas 30 years after diagnosis and 26 years since his last resected liver recurrence.

scholarly journals Hepatocellular carcinoma with regional lymphadenopathy caused by sarcoid-like reaction: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Tomoko Mizota ◽  
Masato Suzuoki ◽  
Saya Kaku ◽  
Kenichi Mizunuma ◽  
Kazuto Ohtaka ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Granulomatous Inflammation ◽  
Giant Cells ◽  
Epithelioid Cell ◽  
Imaging Modalities ◽  
Hepatoduodenal Ligament ◽  
Regional Lymph Nodes ◽  
Multiple Imaging

Abstract Background Sarcoid-like reaction (SLR) is a histological pattern of granulomatous inflammation that is clinically differentiated from sarcoidosis. Since SLR is known to occur in several neoplasias and occasionally causes lymphadenopathy and mimics metastatic malignancy, it needs to be considered whether lymphadenopathy is due to metastasis or SLR for the choice of cancer treatment. Few cases of hepatocellular carcinoma (HCC) with SLR have been reported. Here, a case of HCC with lymphadenopathy diagnosed as SLR without metastasis is presented. Case presentation A 69-year-old woman was admitted to our hospital because of upper abdominal pain. She tested positive for hepatitis C virus ribonucleic acid. Imaging modalities showed an 81 × 65-mm-sized tumor with multiple nodules in segment 3 and a 17 × 12-mm-sized tumor in segment 5 with a common HCC enhancement pattern. In addition, a lymph node in the hepatoduodenal ligament was enlarged at 13 mm in size, suggesting the metastasis of HCC. Hepatectomy of the lateral segment and segment 5 and lymph node dissection in the hepatoduodenal ligament were performed. Both tumors in segments 3 and 5 were pathologically diagnosed as HCC without vessel invasion. The tumors contained necrotic cells and epithelioid cell granulomas with multinucleated giant cells, which is typically observed in sarcoidosis. The dissected lymph nodes also contained epithelioid cell granulomas, as well as giant cells with asteroid bodies. There was no malignancy in the lymph nodes. The pathological findings suggested the coexistence of malignancy and sarcoidosis. However, since the patient did not show any typical findings of pulmonary or cardiac sarcoidosis, the case was diagnosed as HCC with SLR in the primary lesion and regional lymph nodes. Conclusions SLR needs to be considered in the differential diagnosis when a cancer patient develops lymphadenopathy. However, lymphadenopathy due to SLR is indistinguishable from that due to metastasis even when using multiple imaging modalities. Pathological examinations may be helpful for the diagnosis.

Autologous blood storage before hepatectomy for hepatocellular carcinoma with underlying liver disease

2003 ◽  
Vol 90 (1) ◽  
pp. 23-28 ◽  
Author(s):  
T. Itamoto ◽  
K. Katayama ◽  
H. Nakahara ◽  
H. Tashiro ◽  
T. Asahara
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Autologous Blood ◽  
Blood Storage ◽  
Underlying Liver Disease

scholarly journals Fibrolamellar Hepatocellular Carcinoma and Noncirrhotic Hyperammonemic Encephalopathy

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Oscar Suarez ◽  
María Perez ◽  
Martin Garzon ◽  
Rodrigo Daza ◽  
Geovanny Hernandez ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Weight Loss ◽  
Clinical Presentation ◽  
Young Patients ◽  
Fibrolamellar Hepatocellular Carcinoma ◽  
Underlying Liver Disease ◽  
Hyperammonemic Encephalopathy ◽  
Cadaver Donor ◽  
Atypical Manifestation ◽  
Donor Transplant

Fibrolamellar hepatocarcinoma is an infrequent liver tumor, currently considered to be a variant different from hepatocarcinoma. The differences lie in genomic alterations, a greater prevalence of fibrolamellar hepatocarcinoma in young patients, and its lack of association with underlying liver disease. The clinical presentation is unspecific, with symptoms ranging from abdominal pain, malaise, and weight loss to atypical manifestation which include hyperammonemic encephalopathy. We present the case of a 33-year-old woman with no prior medical history who presented with a coma and a diagnosis of inoperable fibrolamellar hepatocarcinoma requiring a cadaver donor transplant. While she was on the waiting list, she received hemofiltration and ammonium benzoate treatment, with progressive improvement in her state of consciousness.

scholarly journals Ultrasound-Guided Hook-Wire Localization for Surgical Excision of Non-Palpable Superficial Inguinal Lymph Nodes in Dogs: A Pilot Study

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2314
Author(s):  
Alessio Pierini ◽  
Veronica Marchetti ◽  
Matteo Rossanese ◽  
Riccardo Finotello ◽  
Andrea Cattai ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Clinical Decision Making ◽  
Surgical Excision ◽  
High Rate ◽  
Ultrasound Guided ◽  
Regional Lymph Nodes ◽  
Localization Method ◽  
Operative Complications ◽  
Hook Wire ◽  
Post Operative Complications

The evaluation of loco-regional lymph nodes (LN) plays an important prognostic role and assists the clinical decision making in canine cancer patients. Excision of non-palpable LN can be challenging. The aim of the study was to evaluate surgical time, successful excision rate and surgical complications associated with the use of an ultrasound-guided hook-wire (UGHW) LN localization method for non-palpable superficial inguinal LN (SILN) in dogs. Dogs that presented for excision of non-palpable SILN, performed with the aid of an UGHW placement, were enrolled. Information including signalment, SILN width, UGHW placement and surgical procedure time, hook-wire position, successful excision and intra- and post-operative complications were reviewed. Seventeen dogs were enrolled. Median LN width was 3 mm (range 2–11). Median time of preoperative UGHW placement and surgical LN excision was 8 min and 15 min, respectively. Successful SILN excision was achieved in all cases. Two minor intra-operative (hook migration and wire fragmentation) and one minor post-operative complications (seroma) were observed. No major intraoperative or post-operative complications occurred. The UGHW LN localization method is safe and effective and may allow a high rate of successful SILN excisions in dogs. This method has the potential to facilitate LN excision for other superficial LN locations.

scholarly journals Dermatofibrosarcoma Protuberans of Scalp With Cervical Lymph Node Metastasis

Sarcoma ◽  
2004 ◽  
Vol 8 (1) ◽  
pp. 43-45 ◽  
Author(s):  
Pawan Lal ◽  
Arun Goel ◽  
A. K. Mandal
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymph Nodes ◽  
Regional Lymph Node ◽  
Radical Neck Dissection ◽  
Dermatofibrosarcoma Protuberans ◽  
Wide Excision ◽  
High Rate ◽  
Regional Lymph Nodes ◽  
Node Metastasis

Dermatofibrosarcoma protuberans (DFSP) is an uncommon, slow growing and locally aggressive tumor of the skin with a high rate of recurrence even after supposedly wide excision. The reports of regional lymph node metastasis and distant metastasis are very rare. Because of the extreme rarity of these cases with metastasis, the experience with management of such patients is very limited. A case of recurrent DFSP of scalp, with metastasis to the regional lymph nodes, in a 17-year-old boy is reported here. This is the second case of DFSP involving scalp and 16th case of DFSP of all sites metastasizing to the regional lymph nodes reported in literature. The patient was treated with wide excision of the lesion and ipsilateral radical neck dissection (including excision of overlying involved skin).

scholarly journals NAFLD may be a common underlying liver disease in patients with hepatocellular Carcinoma in the United States

Hepatology ◽  
2002 ◽  
Vol 36 (6) ◽  
pp. 1349-1354 ◽  
Author(s):  
Jorge A. Marrero ◽  
Robert J. Fontana ◽  
Grace L. Su ◽  
Hari S. Conjeevaram ◽  
Dawn M. Emick ◽  
...  
Keyword(s):  
United States ◽  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
The United States ◽  
Underlying Liver Disease

scholarly journals A Case Report of Hepatocellular Carcinoma Associated with Sarcoid Reaction in Regional Lymph Nodes

2007 ◽  
Vol 40 (3) ◽  
pp. 271-276 ◽  
Author(s):  
Soon-Myoung Kang ◽  
Akihiro Murata ◽  
Masatoshi Shibutani ◽  
Seika Tei ◽  
Shinobu Yamada ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Case Report ◽  
Lymph Nodes ◽  
Regional Lymph Nodes ◽  
Sarcoid Reaction
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