A 15-Year Nationwide Epidemiological Analysis of Guillain-Barré Syndrome in Taiwan

2015 ◽  
Vol 44 (4) ◽  
pp. 249-254 ◽  
Author(s):  
Wan-Chun Huang ◽  
Chin-Li Lu ◽  
Solomon Chih-Cheng Chen
Keyword(s):  
Large Scale ◽  
Guillain Barre Syndrome ◽  
Accurate Estimation ◽  
Research Database ◽  
Crude Incidence ◽  
Female Rate ◽  
Guillain Barré Syndrome ◽  
Life Threatening ◽  
Guillain Barré ◽  
Male To Female

Background: Guillain-Barré syndrome (GBS) is a potentially life-threatening disease that typically occurs after a preceding infectious disease. An accurate estimation of GBS incidence would be useful for investigating the potential causal relationships between risk factors and GBS. Here we described the nationwide incidence of GBS in Taiwan. Methods: The cases of GBS were obtained from all admission records of the National Health Insurance Research Database. We identified all of the first-admitted GBS patients by a code of ICD-9-CM 357.0 presented at the discharge diagnoses in admission records between 1997 and 2011. Calendar year, age, and sex-specific incidence, and seasonal variation were estimated. Results: A total of 5,998 patients were identified. The male-to-female rate ratio was 1.54. The crude incidence rate was 1.65 per 100,000 person-years. The incidence of GBS was lowest in people aged less than 20 and increased with age, especially in people older than 50 years. In spring, the incidence was 10% higher than in other seasons. Conclusions: The overall incidence is in line with previous large-scale studies. A significant higher rate in spring is also shown. The potential reasons for the seasonality and higher incidence among older patients should be further investigated.

Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyradiculoneuropathy in Pregnancy

2018 ◽  
Author(s):  
Pariwat Thaisetthawatkul ◽  
Eric Logigian
Keyword(s):  
Fetal Outcome ◽  
Chronic Inflammatory Demyelinating Polyradiculoneuropathy ◽  
Guillain Barre Syndrome ◽  
Progressive Muscle Weakness ◽  
Immune Mediated ◽  
Guillain Barré Syndrome ◽  
Viral Illness ◽  
Life Threatening ◽  
Depolarizing Agents ◽  
Guillain Barré

Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are both immune-mediated diseases of the peripheral nervous system that typically present with symmetric, progressive muscle weakness, areflexia, and sensory symptoms or signs. GBS evolves rapidly with a nadir at 2–4 weeks usually with an antecedent viral illness, while CIDP progresses more slowly over months to years. GBS is sometimes complicated by life-threatening respiratory failure or dysautonomia. Onset of GBS and relapse of CIDP can occur during pregnancy or postpartum. But with appropriate supportive care and immunotherapy, maternal and fetal outcome in both conditions is typically excellent. The exception is fetal outcome in GBS triggered by maternal CMV or Zika infection transmitted to the fetus. Full-term vaginal delivery and regional anesthesia are preferred in maternal GBS and CIDP, but if C-section and general anesthesia are indicated, non-depolarizing agents such as succinylcholine should be avoided.

scholarly journals Effects of intravenous immunoglobulin therapy on patients of guillain barré syndrome in intensive care unit of BSMMU - a retrospective study

2009 ◽  
Vol 21 (2) ◽  
pp. 72-75
Author(s):  
Debasish Banik ◽  
Qumrul Huda ◽  
Labib Imran Faruque ◽  
Md Abdul Hye
Keyword(s):  
Retrospective Study ◽  
Early Phase ◽  
Average Duration ◽  
Immunoglobulin Therapy ◽  
Guillain Barre Syndrome ◽  
Intravenous Immunoglobulin Therapy ◽  
Duration Of Stay ◽  
Guillain Barré Syndrome ◽  
Life Threatening ◽  
Guillain Barré

Acute polyneuropathy or Guillain Barré syndrome (GBS) following respiratory, gastrointestinal and other illness cause a world wide morbidity and mortality. Immunotherapy (IgG) is early phase of GBS is supposed to reduce life threatening complications. In our retrospective study in ICU, BSMMU Dhaka from January 2007 to December 2008, we included 43 patients admitted during that time. Among the patients 15 patients who received IgG therapy, 1 (one) patient died and 8 patients died among 28 who did not receive Immunotherapy. Recovery rate was 91.66% among IgG group and 66.67% in non IgG group. Ventilated Patients were 53.33% in IgG group and 71.43% patients were in non IgG group. The average duration of stay was 35 days in IgG group and 39.18 days in non-IgG group. The average duration of stay was 22.57 days in IgG group who received immunotherapy in 0-4 days of onset of symptoms and 45.88 days in who got immunotherapy in 5-8 days of onset of symptoms. It is clearly evident that IgG therapy in early phase of GBS reduces, morality, morbidity and duration of hospital (ICU) stay and IgG therapy in early phase of GBS is a better treatment option. Key Words: GBS, immunoglobulin. Journal of BSA, 2008; 21(2): 72-75

Life Threatening Guillain-Barre Syndrome Attributed to Infliximab After Ten Years of Therapy: A Case Report

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S1185
Author(s):  
Neethu Nair ◽  
Venkata Vedantam ◽  
Joseph Maguire ◽  
Tyler Aasen ◽  
James Swenson
Keyword(s):  
Case Report ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Life Threatening ◽  
Guillain Barré

Guillain-Barré syndrome, about a disease that is a challenge for doctors of various specialties

2018 ◽  
Vol 2 (2) ◽  
pp. 15-19
Author(s):  
Natalia Musiał ◽  
Agnieszka Jankowicz-Szymańska ◽  
Jacek A. Pietrzyk
Keyword(s):  
Guillain Barre Syndrome ◽  
Special Role ◽  
Disease Entity ◽  
Guillain Barré Syndrome ◽  
Life Threatening ◽  
Close Cooperation ◽  
Guillain Barré ◽  
Short Time ◽  
Post Infectious

Although the Guillain-Barré syndrome is relatively rare, it is a disease entity that doctors of different specialties and physiotherapists should know as much as possible. This is a post-infectious autoimmune polyneuropathy. This condition falls on the patient unexpectedly and in a short time can lead to damage to many organs and even life-threatening. Due to the multitude and variety of symptoms, treatment of the Guillain-Barré syndrome, more than other diseases, requires close cooperation of the entire therapeutic team. A physiotherapist plays a special role in working with a patient with the Guillain-Barré syndrome. Restoration of lost or limited functions requires time, patience, knowledge and experience to select the methods of working with the patient in the most effective way.

scholarly journals The Epidemiology of Guillain-Barré Syndrome in Children under 15 Years Old in Southwest Iran

2017 ◽  
Vol 2 (3) ◽  
pp. 1-8 ◽  
Author(s):  
Ali Akbar Momen ◽  
Abdolhussein Shakurnia
Keyword(s):  
Incidence Rate ◽  
Acute Flaccid Paralysis ◽  
Annual Incidence ◽  
Flaccid Paralysis ◽  
Guillain Barre Syndrome ◽  
National Database ◽  
Accurate Estimation ◽  
Annual Incidence Rate ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Background: Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy, which has become the most common cause of acute flaccid paralysis. An accurate estimation of GBS occurrence would be useful for investigating the potential causal relationships between risk factors and GBS. The aim of the study was to analyze the incidence, annual time trend, and some epidemiological aspects of GBS in children in the Southwest of Iran. Methods: This was a retrospective study conducted by the Department of Pediatrics of Ahvaz Jundishapur University of Medical Sciences from January 2006 to December 2015. We extracted data from the national database of Acute Flaccid Paralysis Surveillance System. Results: A total of 184 subjects with GBS were assessed. The mean age of subjects was 5.43 ± 4.07 years. The average annual incidence rate of GBS was 1.51 per 100,000 children under 15 years old (95% CI: 1.29-1.73). There was no significant statistical difference in GBS incidence rate between girls and boys (p = 0.376). The highest and lowest proportions of the GBS occurrences were in autumn (32.2%) and summer (14.7%), respectively. Conclusions: The findings indicated that the annual incidence rate of GBS in this study was similar to those in other studies in this area.

Guillain–Barre syndrome: a rare complication of leptospirosis and scrub typhus co-infection

2019 ◽  
Vol 49 (3) ◽  
pp. 248-249 ◽  
Author(s):  
Nishant Dev ◽  
Rahul Kumar ◽  
Dilip Kumar
Keyword(s):  
Scrub Typhus ◽  
Case Reports ◽  
Rare Complication ◽  
Nerve Conduction Studies ◽  
Guillain Barre Syndrome ◽  
First Case ◽  
Immune Mediated ◽  
Guillain Barré Syndrome ◽  
Life Threatening ◽  
Guillain Barré

Guillain–Barré syndrome (GBS) is a potentially life-threatening immune-mediated acute inflammatory polyneuropathy associated with several antecedent infections. We report a 20-year-old man with GBS associated with concurrent leptospirosis and scrub typhus infection. GBS was confirmed with clinical examination and nerve conduction studies. There have been case reports of GBS in association with Leptospira and Orienta tsusugamushi separately. However, this may be the first case report of GBS associated with concurrent diseases.

scholarly journals Prolonged Zika virus viremia in a patient with Guillain-Barré syndrome in Trinidad and Tobago

2017 ◽  
Vol 41 ◽  
pp. 1 ◽  
Author(s):  
Gabriel Gonzalez-Escobar ◽  
Anne Marie Valadere ◽  
Rosmond Adams ◽  
Karen Polson-Edwards ◽  
Avery Q.J. Hinds ◽  
...  
Keyword(s):  
Public Health ◽  
Zika Virus ◽  
Large Scale ◽  
Acute Infection ◽  
Health Agency ◽  
Guillain Barre Syndrome ◽  
Health Concern ◽  
Guillain Barré Syndrome ◽  
The Caribbean ◽  
Guillain Barré

An emerging mosquito-borne flavivirus, Zika virus (ZIKV) is a significant public health concern because of the syndromes associated with the infection. In addition, ZIKV is considered a major problem due to large-scale spread of the disease and the possible clinical complications for the central nervous system, especially Guillain-Barré syndrome (GBS) and microcephaly. Since the introduction of ZIKV in the Caribbean, molecular detection of the viral RNA has been utilized as a more specific and sensitive approach to demonstrating acute infection. However, it is generally accepted that the virus has a short viremic period, generally less than 5 days. Serologic testing has the inconvenience of strong cross-reactivity among flaviviruses, such as dengue and yellow fever. As part of the laboratory surveillance activities for Zika and other arboviruses at the Caribbean Public Health Agency, in 2016 a sample from a male who was clinically diagnosed with GBS tested positive for Zika virus by real-time polymerase chain reaction (rRT-PCR). The serum sample had been taken on day 21 after the onset of symptoms. The case had initially been characterized as a typical ZIKV infection (mild fever with a generalized maculopapular rash). Later, weakness of limbs and other peripheral neurological symptoms appeared. Enzyme-linked immunoassay (ELISA) showed that the sample was negative for IgM antibodies against Zika, Chikungunya, and dengue viruses. The plaque reduction neutralization test was positive for ZIKV. This indicated parallel development of viremia and immune response against ZIKV. Recent reports have demonstrated a longer duration of the viremia in ZIKV infections. However, our report is the first one that links the infection with extended viremia and the development in parallel of a GBS case.

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