Determination of Renal Plasma Flow by Endogenous Hippuric Acid Clearance in the Conscious Rat

2015 ◽  
pp. 211-216 ◽  
Author(s):  
Eva Baunack ◽  
Klaus G�rtner
Keyword(s):  
Plasma Flow ◽  
Hippuric Acid ◽  
Renal Plasma Flow ◽  
Conscious Rat ◽  
Acid Clearance

Technetium-99mL,l-ethylenedicysteine clearance and correlation with iodine-125 orthoiodohippurate for the determination of effective renal plasma flow

1996 ◽  
Vol 23 (4) ◽  
pp. 365-370 ◽  
Author(s):  
Michel Stoffel ◽  
François Jamar ◽  
Chris Van Nerom ◽  
Alfons Verbruggen ◽  
Tatiana Besse ◽  
...  
Keyword(s):  
Plasma Flow ◽  
Renal Plasma Flow ◽  
Effective Renal Plasma Flow ◽  
Iodine 125

Comparison of 99Tcm-mercaptoacetyltriglycine and 131I-orthoiodohippurate in determination of effective renal plasma flow (ERPF)

1989 ◽  
Vol 10 (2) ◽  
pp. 99-108 ◽  
Author(s):  
HUSSEIN M. ABDEL-DAYEM ◽  
SAMY SADEK ◽  
RIAD AL-BAHAR ◽  
MOHAMMED SABHA ◽  
MOHAMMAD EL-SAYED
Keyword(s):  
Plasma Flow ◽  
Renal Plasma Flow ◽  
Effective Renal Plasma Flow

Effect of furegrelate on renal plasma flow after angiotensin II infusion

1990 ◽  
Vol 68 (4) ◽  
pp. 500-504 ◽  
Author(s):  
Ravi D. Kaushal ◽  
Thomas W. Wilson
Keyword(s):  
Angiotensin Ii ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Plasma Flow ◽  
Renal Plasma Flow ◽  
Hydrolysis Product ◽  
Sprague Dawley ◽  
Renal Vasoconstriction ◽  
Acid Clearance ◽  
Thromboxane Synthetase

We had previously shown that selective thromboxane synthetase inhibition with furegrelate increases urinary excretion of 6-ketoPGF1α, the hydrolysis product of prostacyclin after stimulation of renal prostaglandin synthesis with furosemide. The present study assessed the functional significance of this "redirection" of prostaglandin formation using a more physiologic stimulus, angiotensin II. Sprague–Dawley rats (n = 27) were fitted with a transabdominal bladder cannula. Five days later they were given angiotensin II (10 mg∙kg−1∙min−1) by intravenous infusion. After 30 min, an infusion of furegrelate, 2 mg/kg, then 2 mg∙kg−1∙h−1, (n = 9); indomethacin, 2 mg/kg, then 2 mg∙kg−1∙h−1 (n = 9); or vehicle, 250 μL, then 0.018 mL/min (n = 9) was begun for 60 min. Clearance of [14C]para-aminohippuric acid was taken as a measure of renal plasma flow. Angiotensin II raised the mean arterial pressure in all groups. Administration of furegrelate or indomethacin did not change mean arterial pressure or heart rate. Angiotensin II reduced [14C]p-aminohippuric acid clearance by about 32% (1.42 ± 0.18 to 0.97 ± 0.07 mL∙min−1∙100 g−1, p < 0.05). Furegrelate attenuated this renal vasoconstriction (0.97 ± 0.07 to 1.38 ± 0.17 mL∙min−1∙100 g−1, p < 0.05), while indomethacin increased it by a further 32% (1.78 ± 0.12 to 1.20 ± 0.12 mL∙min−1∙100 g−1, p < 0.05). Vehicle alone had no effect. Furegrelate reduced serum thromboxane B2 by 90% (6.52 ± 0.030 to 0.7 ± 0.21 ng/100 μL, p < 0.05), while indomethacin reduced it by 73% (5.9 ± 0.99 to 1.4 ± 0.20 ng/100 μL, p < 0.05). We conclude that furegrelate attenuates the renal vasoconstriction of angiotensin II, presumably by enhancing the formation of vasodilator prostaglandins.Key words: angiotensin II, furegrelate, indomethacin, para-aminohippuric acid clearance.

Glomerular filtration and renal plasma flow during hyperthermia

1960 ◽  
Vol 198 (5) ◽  
pp. 1044-1048 ◽  
Author(s):  
G. S. Kanter
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Glomerular Filtration ◽  
Plasma Volume ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Control Value ◽  
Acid Clearance ◽  
Anesthetized Dogs

The purpose of this study was to investigate the factors that determine the direction and magnitude of the alteration in GFR (glomerular filtration rate) and RPF (renal plasma flow) in hyperthermia. The investigation was conducted on anesthetized dogs. Creatinine clearance was used as a measure of GFR and para-aminohippuric acid clearance was used as a measure of RPF. The GFR in 12 mildly dehydrated dogs went from a control value of 68.4 ± 4.5 ml/min. at RT (rectal temperature) of 38.9°C to a GFR of 25.1 ± 8.5 ml/min. at a RT of 42.1°C at the end of 5 hours of exposure to heat. Final dehydration averaged –2.0% body weight. The fall in GFR and RPF was not due to dehydration for in a group of six hydrated dogs (+4% body wt. at end) similar results were obtained. No decrease in GFR or RPF occurred in either hydrated or dehydrated dogs until severe hyperthermia (> 41.2°C) was present. Though there was a decline in blood pressure towards the end of each experiment, in both groups, the decrease in GFR and RPF preceded any marked fall in pressure. Both groups showed an increase in hematocrit and a decrease in plasma volume (measured by T-1824 dilution) which became marked at the end of 5 hours of exposure to heat. The decrease in GFR and RPF appears directly related to the hyperthermia for upon rapid cooling GFR and RPF increases towards normal in spite of the persisting decreased blood pressure and plasma volume and increased hematocrit.

10. Determination of renal plasma flow from the extraction fraction of 99Tcm-DTPA using the Patlak plot method

1992 ◽  
Vol 13 (1) ◽  
pp. 379
Author(s):  
T. Aburano ◽  
N. Shuke ◽  
T. Takayama ◽  
K. Yokoyama ◽  
T. Michigishi ◽  
...  
Keyword(s):  
Plasma Flow ◽  
Renal Plasma Flow ◽  
Patlak Plot ◽  
Extraction Fraction

A Simplified Method for the Routine Determination of Effective Renal Plasma Flow

1986 ◽  
Vol 11 (11) ◽  
pp. 758-759
Author(s):  
JOHN L. FLOYD ◽  
DONALD E. JACKSON ◽  
JIM M. THOMAS
Keyword(s):  
Plasma Flow ◽  
Renal Plasma Flow ◽  
Effective Renal Plasma Flow ◽  
Simplified Method

PAH extraction and estimation of plasma flow in human postischemic acute renal failure

1999 ◽  
Vol 277 (2) ◽  
pp. F312-F318 ◽  
Author(s):  
Geraldine Corrigan ◽  
Deepa Ramaswamy ◽  
Osun Kwon ◽  
F. Graham Sommer ◽  
Edward J. Alfrey ◽  
...  
Keyword(s):  
Renal Failure ◽  
Blood Flow ◽  
Acute Renal Failure ◽  
Renal Blood Flow ◽  
Plasma Flow ◽  
Renal Allograft ◽  
Renal Plasma Flow ◽  
Pah Clearance ◽  
Normal Controls

We determined the effect of postischemic injury to the human renal allograft on p-aminohippurate (PAH) extraction (EPAH) and renal blood flow. We evaluated renal function in 44 allograft recipients on two occasions: 1–3 h after reperfusion ( day 0) and again on postoperative day 7. On day 0 subsets underwent intraoperative determination of renal blood flow ( n = 35) by Doppler flow meter and EPAH( n = 25) by renal venous assay. Blood flow was also determined in another subset of 16 recipients on postoperative day 7 by phase contrast-cine-magnetic resonance imaging, and EPAH was computed from the simultaneous PAH clearance. Glomerular filtration rate (GFR) on day 7 was used to divide subjects into recovering ( n = 23) and sustained ( n = 21) acute renal failure (ARF) groups, respectively. Despite profound depression of GFR in the sustained ARF group, renal plasma flow was only slightly depressed, averaging 296 ± 162 ml ⋅ min−1 ⋅ 1.73 m−2 on day 0 and 202 ± 72 ml ⋅ min−1 ⋅ 1.73 m−2 on day 7, respectively. These values did not differ from corresponding values in the recovering ARF group: 252 ± 133 and 280 ± 109 ml ⋅ min−1 ⋅ 1.73 m−2, respectively. EPAH was profoundly depressed on day 0, averaging 18 ± 14 and 10 ± 7% in recovering and sustained ARF groups, respectively, vs. 86 ± 6% in normal controls ( P < 0.001). Corresponding values on day 7remained significantly depressed at 65 ± 20 and 11 ± 22%, respectively. We conclude that postischemic injury to the renal allograft results in profound impairment of EPAH that persists for at least 7 days, even after the onset of recovery. An ensuing reduction in urinary PAH clearance results in a gross underestimate of renal plasma flow, which is close to the normal range in the initiation, maintenance, and recovery stages of this injury.

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