Experimental Immunization against Leukemia in Guinea Pigs1

2015 ◽  
pp. 654-661
Author(s):  
Ludwik Gross ◽  
Yolande Dreyfuss
Keyword(s):  
Experimental Immunization

Experimental immunization with attenuated mutants of Pseudomonas aeruginosa

1973 ◽  
Vol 19 (5) ◽  
pp. 573-580
Author(s):  
Delfa Syeklocha
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibody Response ◽  
Specific Antibody ◽  
Complex Medium ◽  
Specific Antibody Response ◽  
Intraperitoneal Route ◽  
Viable Cells ◽  
Sublethal Doses ◽  
Experimental Immunization

Two attenuated mutants of Pseudomonas aeruginosa (PA7), designated P-8 and P-11, were tested for their immunizing potential in mice. One or three sublethal doses of viable cells of either mutant given by the intraperitoneal route did not increase the resistance of the animals even with time, to challenge with the virulent parent form. However, increased survival was obtained in groups of mice immunized with six doses of either a viable or formalinized preparation of the P-8 mutant, injected intraperitoneally or intravenously. An elevated specific antibody response was found only in the sera of animals immunized with the largest doses of P-8 and this antiserum protected normal animals when given intraperitoneally 4 h before challenge.The two mutants appear to be similar, if not identical, with the parent form, with the exception of their slower growth in complex medium and their reduced virulence for mice.

scholarly journals Molecular epidemiology of infections caused by group B Streptococcus in pregnant women and newborns, and development of preventive vaccines

2018 ◽  
Vol 67 (5) ◽  
pp. 62-73
Author(s):  
Vasilisa A. Vasilyeva ◽  
Elena V. Shipitsyna ◽  
Kira V. Shalepo ◽  
Alevtina M. Savicheva
Keyword(s):  
Capsular Polysaccharide ◽  
Vaccine Development ◽  
Current Knowledge ◽  
Group B Streptococcus ◽  
Epidemiological Data ◽  
Group B Streptococci ◽  
Group B ◽  
Sequence Types ◽  
Experimental Immunization ◽  
Selection Of

Hypothesis/aims of study. The present analysis was undertaken to summarize current knowledge about molecular properties of group B streptococci (GBS), emphasizing potential targets of vaccines against neonatal GBS infection. Study design, materials, and methods. This review is based on articles published mainly in the last ten years. Results. Epidemiological data on serotypes, multilocus sequence types, clonal complexes of GBS and their relationship are presented. Genetic events in GBS populations indicate significant obstacles to vaccine development. We described key properties of major GBS virulence factors, such as capsular polysaccharide, pili, and cell adhesion molecules, as well as results of experimental immunization on their basis. Conclusion. The population of invasive GBS strains is molecularly and genetically heterogeneous, which complicates selection of vaccine targets. Capsular switching, a low level of immunogenicity and variability of population composition are the most important factors that necessitate the accumulation and monitoring of molecular epidemiological data.

Experimental immunization of horses with hela cells

1964 ◽  
Vol 58 (2) ◽  
pp. 965-967
Author(s):  
I. I. Podoplelov ◽  
E. P. Ugryumov ◽  
A. F. Zakharov ◽  
N. A. Roslyakova
Keyword(s):  
Hela Cells ◽  
Experimental Immunization
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