Recent Development of Pineal Melatonin and Its Receptors in Humans1

2015 ◽  
pp. 133-146
Author(s):  
S. F. Pang ◽  
C. S. Pang ◽  
A. M. S. Poon ◽  
S. Y. W. Shiu ◽  
Y. Song ◽  
...  
Keyword(s):  
Pineal Melatonin

Monosodium glutamate administration early in life alters pineal melatonin nocturnal profile in adulthood

2021 ◽  
Vol 4 (1) ◽  
pp. 99-114
Author(s):  
Janaína B Garcia ◽  
Fernanda G Do Amaral ◽  
Daniela C Buonfiglio ◽  
Rafaela FA Vendrame ◽  
Patrícia L Alves ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Weight ◽  
Pineal Gland ◽  
Serum Insulin ◽  
Monosodium Glutamate ◽  
Female Rats ◽  
Pineal Melatonin ◽  
Melatonin Synthesis ◽  
Male And Female Rats ◽  
Melatonin Production

The pineal gland synthesizes melatonin exclusively at night, which gives melatonin the characteristic of a temporal synchronizer of the physiological systems. Melatonin is a regulator of insulin activities centrally and also peripherally and its synthesis is reduced in diabetes.  Since monosodium glutamate (MSG) is often used to induce the type 2 diabetic and metabolic syndrome in animal models, the purpose of this work is to evaluate the potential effects of MSG given to neonates on the pineal melatonin synthesis in different aged male and female rats. Wistar rats were subcutaneously injected with MSG (4mg/g/day) or saline solution (0.9%) from the second to eighth post-natal day. The circadian profiles both melatonin levels and AANAT activity were monitored at different ages. Body weight, naso-anal length, adipose tissues weight, GTT, ITT and serum insulin levels were also evaluated. Typical obesity with the neonatal MSG treatment was observed, indicated by a great increase in adipose depots without a concurrent increase in body weight. MSG treatment did not cause hyperglycemia or glucose intolerance, but induced insulin resistance. An increase of melatonin synthesis at ZT 15 with phase advance was observed in in some animals. The AANAT activity was positively parallel to the melatonin circadian profile. It seems that MSG causes hypothalamic obesity which may increase AANAT activity and melatonin production in pineal gland. These effects were not temporally correlated with insulin resistance and hyperinsulinemia indicating the hypothalamic lesions, particularly in arcuate nucleus induced by MSG in early age, as the principal cause of the increase in melatonin production.

Evidence for feedback control of pineal melatonin secretion

2013 ◽  
Vol 542 ◽  
pp. 123-125 ◽  
Author(s):  
Tracy A. Bedrosian ◽  
Kamillya L. Herring ◽  
James C. Walton ◽  
Laura K. Fonken ◽  
Zachary M. Weil ◽  
...  
Keyword(s):  
Feedback Control ◽  
Melatonin Secretion ◽  
Pineal Melatonin

Local Corticosterone Infusion Enhances Nocturnal Pineal Melatonin ProductionIn Vivo

2009 ◽  
Vol 21 (2) ◽  
pp. 90-97 ◽  
Author(s):  
P. A. C. M. Fernandes ◽  
B. Bothorel ◽  
D. Clesse ◽  
A. W. A. Monteiro ◽  
C. Calgari ◽  
...  
Keyword(s):  
Pineal Melatonin

Experimentally-induced diabetes reduces nocturnal pineal melatonin content in the Syrian hamster

1983 ◽  
Vol 76 (1) ◽  
pp. 199-201 ◽  
Author(s):  
Thomas H Champney ◽  
George C Brainard ◽  
Bruce A Richardson ◽  
Russel J Reiter
Keyword(s):  
Syrian Hamster ◽  
Pineal Melatonin ◽  
Experimentally Induced

Fluctuation of Blood Melatonin Concentrations With Age: Result of Changes in Pineal Melatonin Secretion, Body Growth, and Aging

1990 ◽  
Vol 8 (2) ◽  
pp. 179-192 ◽  
Author(s):  
S. F. Pang ◽  
C. W. Tsang ◽  
G. X. Hong ◽  
P. C. Y. Yip ◽  
P. L. Tang ◽  
...  
Keyword(s):  
Body Growth ◽  
Melatonin Secretion ◽  
Pineal Melatonin ◽  
Growth And Aging

Pineal melatonin in hibernating and aroused golden hamsters (Mesocricetus auratus)

1984 ◽  
Vol 77 (4) ◽  
pp. 759-762 ◽  
Author(s):  
Jiří Vaněček ◽  
Ladislav Janský ◽  
Helena Illnerová ◽  
Klaus Hoffmann
Keyword(s):  
Mesocricetus Auratus ◽  
Pineal Melatonin ◽  
Golden Hamsters

Near-Ultraviolet Radiation Suppresses Pineal Melatonin Content*

Endocrinology ◽  
1986 ◽  
Vol 119 (5) ◽  
pp. 2201-2205 ◽  
Author(s):  
GEORGE C. BRAINARD ◽  
PATRICIA L. PODOLIN ◽  
SANDER W. LEIVY ◽  
MARK D. ROLLAG ◽  
CURTIS COLE ◽  
...  
Keyword(s):  
Ultraviolet Radiation ◽  
Pineal Melatonin ◽  
Near Ultraviolet

Pineal Melatonin in Syrian Hamsters: Circadian and Seasonal Rhythms in Animals Maintained under Laboratory and Natural Conditions

1982 ◽  
Vol 35 (5) ◽  
pp. 342-348 ◽  
Author(s):  
George C. Brainard ◽  
Larry J. Petterborg ◽  
Bruce A. Richardson ◽  
Russel J. Reiter
Keyword(s):  
Natural Conditions ◽  
Seasonal Rhythms ◽  
Syrian Hamsters ◽  
Pineal Melatonin

Long-Term Dynamic in vitro System for Investigating Rat Pineal Melatonin Secretion

1991 ◽  
Vol 3 (5) ◽  
pp. 563-568 ◽  
Author(s):  
Z. Rékési ◽  
V. Csernus ◽  
J. Horvéth ◽  
S. Vigh ◽  
B. Mess
Keyword(s):  
Melatonin Secretion ◽  
In Vitro System ◽  
Pineal Melatonin
Sign in / Sign up

Export Citation Format

Share Document