Activation of Metalloproteinase-2 by Membrane Type Metalloproteinase Expressed on Human Mesangial Cell Membrane

2015 ◽  
pp. 135-140 ◽  
Author(s):  
Naohisa Tomosugi ◽  
Hiroshi Sato ◽  
Motoharu Seiki ◽  
Hideki Yamaya ◽  
Takehisa Yuri ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Mesangial Cell ◽  
Human Mesangial Cell ◽  
Membrane Type

The Actions of C-Type Natriuretic Peptide on Human Mesangial Cell Apoptosis and P53 Expression

2000 ◽  
Vol 6 (S2) ◽  
pp. 624-625
Author(s):  
K. Seta ◽  
C. Wei
Keyword(s):  
Receptor Antagonist ◽  
Natriuretic Peptide ◽  
Cell Apoptosis ◽  
Mesangial Cell ◽  
Mesangial Cells ◽  
Endocrine System ◽  
P53 Gene ◽  
Glomerular Mesangial Cells ◽  
P53 Expression ◽  
Human Mesangial Cell

C-type natriuretic peptide (CNP) of endothelial cell origin via NPR-B receptor mediates antimitogenic and vasodilatory actions. As a circulating endocrine system, CNP plays a fundamental role in cardiorenal regulation. However, the actions of CNP on renal mesangial cell apoptosis remain poorly defined. Apoptosis might plays an important role during development of renal glomerular mesangial cells pathophysiology. The mechanisms of apoptosis include p53-dependent pathway and p53-independent pathway.The hypothesis of this study is that CNP induces apoptosis through the process involving p53 gene in human glomerular mesangial cells via natriuretic peptide biological receptor. Therefore, the current study was designed to investigate the effects of CNP on apoptosis and p53 expression in human mesangial cell in the absence or presence of CNP biological receptor antagonist.Cultured human mesangial cells (Clontech Lab., San Diego, CA) was incubated for 24 hours in the absence or presence of CNP (10-7 M). These studies were repeated with HS 142-1 (HS, 10-5 M), a CNP biological receptor antagonist.

Apolipoprotein E Regulates Primary Cultured Human Mesangial Cell Proliferation

2006 ◽  
Vol 102 (2) ◽  
pp. e62-e70 ◽  
Author(s):  
Yixiang Zhang ◽  
Yuichiro Yasumoto ◽  
Toru Ikeda ◽  
Syozo Takenouchi ◽  
Atsushi Sogabe ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Apolipoprotein E ◽  
Mesangial Cell ◽  
Human Mesangial Cell ◽  
Mesangial Cell Proliferation

Inhibition of Human Mesangial Cell Proliferation by Targeting T-Type Calcium Channels

2009 ◽  
Vol 113 (2) ◽  
pp. e77-e88 ◽  
Author(s):  
Christopher J. Mulgrew ◽  
Andrea Cove-Smith ◽  
Linda M. McLatchie ◽  
Gavin Brooks ◽  
Michael J. Shattock ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Calcium Channels ◽  
Mesangial Cell ◽  
Human Mesangial Cell ◽  
Mesangial Cell Proliferation

Chinese herbs as modulators of human mesangial cell proliferation: Preliminary studies

1998 ◽  
Vol 132 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Yuh-Chi Kuo ◽  
Chang-Ming Sun ◽  
Wei-Jern Tsai ◽  
Jun-Chin Ou ◽  
Wei-Perng Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Chinese Herbs ◽  
Human Mesangial Cell ◽  
Mesangial Cell Proliferation
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