Apolipoprotein E Regulates Primary Cultured Human Mesangial Cell Proliferation

2006 ◽  
Vol 102 (2) ◽  
pp. e62-e70 ◽  
Author(s):  
Yixiang Zhang ◽  
Yuichiro Yasumoto ◽  
Toru Ikeda ◽  
Syozo Takenouchi ◽  
Atsushi Sogabe ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Apolipoprotein E ◽  
Mesangial Cell ◽  
Human Mesangial Cell ◽  
Mesangial Cell Proliferation

Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice

2009 ◽  
Vol 297 (3) ◽  
pp. F679-F684 ◽  
Author(s):  
Mari Tomiyama-Hanayama ◽  
Hiromi Rakugi ◽  
Masaharu Kohara ◽  
Toru Mima ◽  
Yasuo Adachi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Apolipoprotein E ◽  
Interleukin 6 ◽  
Renal Injury ◽  
Mesangial Cell ◽  
Organ Damage ◽  
Glomerular Injury ◽  
Mesangial Cell Proliferation ◽  
Matrix Expansion ◽  
Interleukin 6 Receptor

Hyperlipidemia has been demonstrated to be associated with renal disease, yet the mechanism of renal injury is still poorly understood. Inflammation that occurs with the hyperlipidemia has been considered to play an important role in development of glomerular injury. In the present study, we investigated the role of interleukin-6 (IL-6), a key inflammatory molecule, on renal injury in apolipoprotein E-deficient (ApoE−/−) mice with severe hypercholesterolemia. The 6-wk-old mice were fed a high-fat diet and administered weekly rat anti-IL-6 receptor monoclonal antibody (MR16-1), control rat IgG, or saline for a total of 4 wk. We examined histopathological changes in the kidney and urinary excretion of protein and albumin. Saline- and IgG-treated mice showed remarkable proteinuria at 10 wk of age, whereas MR16-1-treated mice exhibited significantly lower levels. Renal histopathology of saline- and IgG-treated mice revealed striking lipid deposits and foam cells in the glomerular tuft, juxtaglomerular area, and arteriolar wall along with range of mesangial cell proliferation and matrix expansion. Notably, the severity of lipid deposits and mesangial cell proliferation were significantly reduced in MR16-1-treated mice. Immunohistochemistry demonstrated that mesangial IL-6 expression was dramatically reduced in MR16-1-treated mice compared with IgG-treated mice. Blocking the IL-6 receptor prevented progression of proteinuria and renal lipid deposit, as well as the mesangial cell proliferation associated with severe hyperlipoproteinemia. These results clearly demonstrate that IL-6 plays an essential role in the pathogenesis of hyperlipidemia-induced glomerular injury in ApoE−/− mice and suggests the usefulness of anti-IL-6 receptor antibody in treatments for hyperlipidemia-induced organ damage.

Inhibition of Human Mesangial Cell Proliferation by Targeting T-Type Calcium Channels

2009 ◽  
Vol 113 (2) ◽  
pp. e77-e88 ◽  
Author(s):  
Christopher J. Mulgrew ◽  
Andrea Cove-Smith ◽  
Linda M. McLatchie ◽  
Gavin Brooks ◽  
Michael J. Shattock ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Calcium Channels ◽  
Mesangial Cell ◽  
Human Mesangial Cell ◽  
Mesangial Cell Proliferation

Chinese herbs as modulators of human mesangial cell proliferation: Preliminary studies

1998 ◽  
Vol 132 (1) ◽  
pp. 76-85 ◽  
Author(s):  
Yuh-Chi Kuo ◽  
Chang-Ming Sun ◽  
Wei-Jern Tsai ◽  
Jun-Chin Ou ◽  
Wei-Perng Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Mesangial Cell ◽  
Chinese Herbs ◽  
Human Mesangial Cell ◽  
Mesangial Cell Proliferation
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