Comparative Cytoskeletal Analyses of the Inner Ear in Man and the Squirrel Monkey

Author(s):  
K. Nishizaki ◽  
S.-I. Usami ◽  
M. Anniko ◽  
W. Arnold
Keyword(s):  
1987 ◽  
Vol 103 (5) ◽  
pp. 161-169 ◽  
Author(s):  
Toshio Yoshihara ◽  
Shinichi Usami ◽  
Makoto Igarashi ◽  
Cesar Fermin
Keyword(s):  

ORL ◽  
1995 ◽  
Vol 57 (2) ◽  
pp. 87-93 ◽  
Author(s):  
K. Nishizaki ◽  
S.-I. Usami ◽  
M. Anniko ◽  
W. Arnold
Keyword(s):  

1969 ◽  
Vol 45 (1) ◽  
pp. 342-342 ◽  
Author(s):  
C. Wilpizeski ◽  
J. Sataloff ◽  
R. Innis ◽  
W. Shiner

1980 ◽  
Vol 49 (6) ◽  
pp. 1070-1082 ◽  
Author(s):  
J. P. Landolt ◽  
K. E. Money ◽  
E. D. Topliff ◽  
A. D. Nicholas ◽  
J. Laufer ◽  
...  

More than 90 squirrel monkeys with bilateral myringotomies (a small hole in each ear drum) were rapidly decompressed in a hyperbaric chamber according to a special diving profile in which 35% of attempts produced disorders ("hits") confined to the inner ear. Monkeys receiving inner ear hits (as determined by the sudden onset of vigorous head or eye nystagmus during decompression) were tested and killed at times ranging from 1 h to more than 12 mo following the dive. Histologically, in monkeys killed 1 mo or less after the hit, hemorrhage and/or a deep purple-staining precipitated material were frequently found in the otic fluid spaces. In those monkeys killed more than 1 mo after a hit, ectopic new bone growth in the arms of the semicircular canals was a common sequela. New bone growth never appeared in the cochlea. In unaffected ears, and in both ears of control animals, the precipitated material was somewhat less than in ears damaged by decompression; and, furthermore, new bone growth did not occur. Behaviorally, the hit monkeys showed vestibular deficits that were consistent with the structural damage revealed by histology.


1987 ◽  
Vol 103 (3-4) ◽  
pp. 161-169 ◽  
Author(s):  
Toshio Yoshihara ◽  
Shinichi Usami ◽  
Makoto Igarashi ◽  
Cesar D. Fermin
Keyword(s):  

Author(s):  
C.D. Fermin ◽  
M. Igarashi

Otoconia are microscopic geometric structures that cover the sensory epithelia of the utricle and saccule (gravitational receptors) of mammals, and the lagena macula of birds. The importance of otoconia for maintanance of the body balance is evidenced by the abnormal behavior of species with genetic defects of otolith. Although a few reports have dealt with otoconia formation, some basic questions remain unanswered. The chick embryo is desirable for studying otoconial formation because its inner ear structures are easily accessible, and its gestational period is short (21 days of incubation).The results described here are part of an intensive study intended to examine the morphogenesis of the otoconia in the chick embryo (Gallus- domesticus) inner ear. We used chick embryos from the 4th day of incubation until hatching, and examined the specimens with light (LM) and transmission electron microscopy (TEM). The embryos were decapitated, and fixed by immersion with 3% cold glutaraldehyde. The ears and their parts were dissected out under the microscope; no decalcification was used. For LM, the ears were embedded in JB-4 plastic, cut serially at 5 micra and stained with 0.2% toluidine blue and 0.1% basic fuchsin in 25% alcohol.


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