scholarly journals Audiometric Effects of Discrete Laser Irradiation of the Squirrel Monkey Inner Ear

1969 ◽  
Vol 45 (1) ◽  
pp. 342-342 ◽  
Author(s):  
C. Wilpizeski ◽  
J. Sataloff ◽  
R. Innis ◽  
W. Shiner
Author(s):  
K. Nishizaki ◽  
S.-I. Usami ◽  
M. Anniko ◽  
W. Arnold
Keyword(s):  

1987 ◽  
Vol 103 (5) ◽  
pp. 161-169 ◽  
Author(s):  
Toshio Yoshihara ◽  
Shinichi Usami ◽  
Makoto Igarashi ◽  
Cesar Fermin
Keyword(s):  

2005 ◽  
Vol 119 (9) ◽  
pp. 684-692 ◽  
Author(s):  
DongDong Ren ◽  
JingWU Sun ◽  
GuangLun Wan ◽  
Feng Yang ◽  
Fang Shen

Both experimental and clinical studies have demonstrated that carbon dioxide laser is suitable for stapedotomy. The aim of this study was to investigate morphological, electrophysiological and functional changes in the inner ear after irradiation with CO2 laser set with different energy parameters.A cochleostomy in the basal cochlear turn of guinea pig cochleae was performed with CO2 laser of 1, 2 and 3 w, respectively. The cochleae were removed three weeks after laser irradiation. The auditory evoked brainstem response (ABR) was measured before and after laser application and immediately before removal of the cochlea. Immunohistochemical methods were used to examine inducible nitric oxide synthase (iNOS/NOSII) and heat-shock protein 70(Hsp70) concentrations in the cochlea after laser application. The organ of Corti was studied by scanning electron microscopy.Worse hearing loss was observed in animals receiving higher-power CO2 laser. These findings correlated with more intense injury of the cochlear ultrastructure and with positiveexpression of iNOS and Hsp70 in spiral ganglion cells, nerve fibres, supporting cells of the organ of Corti and cells of the spiral ligament.The CO2 laser as a noncontact procedure is shown to be effective and safe if the total amount of energy is kept within the limits applied in this study. Nitric oxide and stressproteins play important roles in the traumatic mechanism of the inner ear, which are related tohearing loss and injury of the ultrastructure of the inner ear.


ORL ◽  
1995 ◽  
Vol 57 (2) ◽  
pp. 87-93 ◽  
Author(s):  
K. Nishizaki ◽  
S.-I. Usami ◽  
M. Anniko ◽  
W. Arnold
Keyword(s):  

1980 ◽  
Vol 49 (6) ◽  
pp. 1070-1082 ◽  
Author(s):  
J. P. Landolt ◽  
K. E. Money ◽  
E. D. Topliff ◽  
A. D. Nicholas ◽  
J. Laufer ◽  
...  

More than 90 squirrel monkeys with bilateral myringotomies (a small hole in each ear drum) were rapidly decompressed in a hyperbaric chamber according to a special diving profile in which 35% of attempts produced disorders ("hits") confined to the inner ear. Monkeys receiving inner ear hits (as determined by the sudden onset of vigorous head or eye nystagmus during decompression) were tested and killed at times ranging from 1 h to more than 12 mo following the dive. Histologically, in monkeys killed 1 mo or less after the hit, hemorrhage and/or a deep purple-staining precipitated material were frequently found in the otic fluid spaces. In those monkeys killed more than 1 mo after a hit, ectopic new bone growth in the arms of the semicircular canals was a common sequela. New bone growth never appeared in the cochlea. In unaffected ears, and in both ears of control animals, the precipitated material was somewhat less than in ears damaged by decompression; and, furthermore, new bone growth did not occur. Behaviorally, the hit monkeys showed vestibular deficits that were consistent with the structural damage revealed by histology.


1994 ◽  
Vol 87 (8) ◽  
pp. 1135-1140 ◽  
Author(s):  
Yosaku SHIOMI ◽  
Jun TUJI ◽  
Yasushi NAITO ◽  
Kazuhiko SHOJI ◽  
Hisayoshi KOJIMA ◽  
...  

Author(s):  
Yasuya Nomura ◽  
Yasuya Nomura ◽  
Yasuya Nomura
Keyword(s):  

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