Long-Term Cyclosporin in Steroid-Dependent Nephrotic Syndrome

2015 ◽  
pp. 19-27 ◽  
Author(s):  
Norishige Yoshikawa ◽  
Ryojiro Tanaka ◽  
Yoshitaka Kitano ◽  
Hajime Nakamura ◽  
Hiroshi Ito
Keyword(s):  
Nephrotic Syndrome ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

MO291RITUXIMAB IS EFFECTIVE AND SAFE IN ADULTS WITH STEROID-DEPENDENT NEPHROTIC SYNDROME: A LONG-TERM, SINGLE-CENTER EXPERIENCE

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Gemma Patella ◽  
Alessandro Comi ◽  
Giuseppe Coppolino ◽  
Nicolino Comi ◽  
Giorgio Fuiano ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Case Series ◽  
Adult Patients ◽  
Single Center ◽  
Single Center Experience ◽  
Steroid Dependent ◽  
The Mean ◽  
Steroid Dependent Nephrotic Syndrome

Abstract Background and Aims Steroid-dependent nephrotic syndrome (SDNS) may require a prolonged multi-drug therapy with risk of drug toxicity and renal failure. Rituximab (RTX) treatment has been found to be helpful in reducing the steroid dosage and the need for immunosuppressants (ISs), but little data are currently available regarding very long-term outcomes in adults. We herein describe a long-term, single-center experience of RTX use in a large series of adults with SDNS. Method We studied 23 adult patients with SDNS (mean age 54.2±17.1 y; 65% male; BMI 28.5±4.7), mostly consequent to membranous (47.8%) or focal glomerulonephritis (30.2 %) who were eligible to start a RTX regimen. Before entering the RTX protocol, proteinuria and eGFR were 7.06±3.87 g/24h and 65.9±28.2 ml/min/1.73 m2, respectively; albumin and CD19/CD20 ratio were 2.9±0.9 g/L and 0.99±0.01 respectively; the mean number of ISs was 2.39±0.89 and the mean annual rate of relapses was 2.2±0.9. Results Patients were followed over a mean follow-up of 64 months (range: 12-144). After RTX (mean dose: 1202.1±372.4 mg) the rate of relapses was virtually nullified (p<0.001). eGFR remained roughly stable (62.1±19.8 ml/min/1.73 m2, p=NS), while proteinuria, albumin, CD19/CD20 and BMI all significantly improved (p ranging from 0.01 to 0.001). The mean number of additional ISs was also reduced (0.44±0.12; p<0.001) and RTX enabled discontinuation of steroids in 13/23 (56.5%) patients. No major adverse events related to therapy were recorded. Conclusion Findings from this large case-series with a remarkable very long follow-up reinforce the role of RTX as an efficient and safe weapon to improve outcomes in adult patients suffering from SDNS.

Long-term ciclosporin treatment in children with steroid-dependent nephrotic syndrome

1993 ◽  
Vol 7 (3) ◽  
pp. 249-252 ◽  
Author(s):  
Ryojiro Tanaka ◽  
Norishige Yoshikawa ◽  
Yoshitaka Kitano ◽  
Hiroshi Ito ◽  
Hajime Nakamura
Keyword(s):  
Nephrotic Syndrome ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Clinical evaluation of chronic nephrotoxicity of long-term cyclosporine A treatment in adult patients with steroid-dependent nephrotic syndrome

Nephrology ◽  
2011 ◽  
Vol 16 (3) ◽  
pp. 319-325 ◽  
Author(s):  
TOMONARI OKADA ◽  
HIROSHI MATSUMOTO ◽  
YUME NAGAOKA ◽  
RYO TOMARU ◽  
HIDEAKI IWASAWA ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Clinical Evaluation ◽  
Cyclosporine A ◽  
Adult Patients ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Long-term low-dose cyclosporin A in steroid dependent nephrotic syndrome of childhood

1992 ◽  
Vol 151 (10) ◽  
pp. 775-778 ◽  
Author(s):  
T. J. Neuhaus ◽  
H. R. Burger ◽  
M. Klingler ◽  
A. Fanconi ◽  
E. P. Leumann
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclosporin A ◽  
Low Dose ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Long-term follow-up after cyclophosphamide therapy in steroid-dependent nephrotic syndrome

2011 ◽  
Vol 26 (6) ◽  
pp. 915-920 ◽  
Author(s):  
Alberto Zagury ◽  
Anne Louise de Oliveira ◽  
Carlos Augusto Pinheiro de Moraes ◽  
Jose Augusto de Araujo Montalvão ◽  
Regina Helena Leite Lemos Novaes ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclophosphamide Therapy ◽  
Steroid Dependent ◽  
Long Term Follow Up ◽  
Steroid Dependent Nephrotic Syndrome

scholarly journals Efficacy and safety of long-term levamisole therapy in maintaining remission in steroid dependent nephrotic syndrome

2017 ◽  
Vol 46 (4) ◽  
pp. 357
Author(s):  
H Dharmawardane ◽  
S Abeyagunawardena ◽  
U I Karunadasa ◽  
A H H M Jayaweera ◽  
A S Abeyagunawardena
Keyword(s):  
Nephrotic Syndrome ◽  
Efficacy And Safety ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Therapeutic Effect of Chai-Ling-Tang (Sairei-to) on the Steroid-dependent Nephrotic Syndrome in Children

1995 ◽  
Vol 23 (03n04) ◽  
pp. 255-260 ◽  
Author(s):  
Xiao-Yun Liu
Keyword(s):  
Nephrotic Syndrome ◽  
Side Effects ◽  
Toxic Effect ◽  
Cytotoxic Agents ◽  
Short Term ◽  
Prednisone Dosage ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome ◽  
Negative Conversion

37 children with steroid-dependent nephrotic syndrome (SDNS) were administered with Chai-Ling-Tang (Sairei-to) under corticosteroid. After treatment with Chai-Ling-Tang, relapse was markedly improved, time for negative conversion of proteinuria shortened, prednisone dosage significantly reduced, and side effects eased. 32 children with SDNS treated with prednisone and cyclophosphamide served as control. Results showed that short-term and long-term relapse and average prednisone dosage were similar between these two groups. It is considered that Chai-Ling-Tang may be a useful substitute for patients with SDNS who fail to respond to or manifest severe toxic effect from cytotoxic agents.

scholarly journals Safety and efficacy of mycophenolate mofetil as first-line immunosuppressive therapy in children with steroid-dependent nephrotic syndrome

2020 ◽  
Vol 23 (6) ◽  
pp. 360-364
Author(s):  
Asmik G. Agaronyan ◽  
Tatyana V. Vashurina ◽  
Svetlana V. Dmitrienko ◽  
Tatyna S. Voznesenskaya ◽  
Olga V. Komarova ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Mycophenolate Mofetil ◽  
Cumulative Dose ◽  
Term Therapy ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Introduction. More than half of children with idiopathic nephrotic syndrome have relapsed or become steroid-dependent after the disease’s onset. So far they, require long-term therapy with glucocorticosteroids and/or other immunosuppressive treatment to maintain remission. Despite the widespread use of immunosuppressive agents, there is no consensus for appropriate first-line therapy. Materials and methods. A retrospective study included children presenting with steroid-dependent nephrotic syndrome who received treatment with mycophenolate mofetil in the Nephrology department between 2003 and 2018 at the National Medical Research Center for Children’s Health (Moscow). Results. In total, withdrawal of corticosteroids was recorded in 24 (85.7%) patients, while the median remission period was 23 [12; 30] months, after glucocorticosteroids cessation - 19 [10; 24.5] months, the cumulative dose of steroids was reduced from 189 [125.9; 240] to 45.5 [19.5; 68.2] mg/kg per year and relapses rate per year from 1.9 [1.35; 2.35] to 0 during a year. Among children who did not overcome steroid dependence, the treatment failed in 3 patients, and in 1 child, the steroid dosage has been reduced to the lower dose. Conclusion. Mycophenolate mofetil has a favorable efficacy due to the significant reduction of the cumulative dose of steroids and maintenance of long-term remission of nephrotic syndrome after glucocorticosteroid cessation and may be recommended as the first-line therapy in children with steroid-dependent nephrotic syndrome.

scholarly journals Long-term repeated rituximab treatment for childhood steroid-dependent nephrotic syndrome

2017 ◽  
Vol 36 (3) ◽  
pp. 257-263 ◽  
Author(s):  
Ji Hyun Kim ◽  
Eujin Park ◽  
Hye Sun Hyun ◽  
Myung Hyun Cho ◽  
Yo Han Ahn ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome
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