Long-term low-dose cyclosporin A in steroid dependent nephrotic syndrome of childhood

1992 ◽  
Vol 151 (10) ◽  
pp. 775-778 ◽  
Author(s):  
T. J. Neuhaus ◽  
H. R. Burger ◽  
M. Klingler ◽  
A. Fanconi ◽  
E. P. Leumann
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclosporin A ◽  
Low Dose ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Linear Growth of Low-Dose Cyclosporin A Therapy in Children with Steroid-Dependent Nephrotic Syndrome

Nephron ◽  
2001 ◽  
Vol 87 (3) ◽  
pp. 293-294 ◽  
Author(s):  
Kenichi Kano ◽  
Kiyoshi Nishikura ◽  
Megumi Hoshi ◽  
Yumi Yamada ◽  
Osamu Arisaka
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclosporin A ◽  
Low Dose ◽  
Linear Growth ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

MO291RITUXIMAB IS EFFECTIVE AND SAFE IN ADULTS WITH STEROID-DEPENDENT NEPHROTIC SYNDROME: A LONG-TERM, SINGLE-CENTER EXPERIENCE

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Gemma Patella ◽  
Alessandro Comi ◽  
Giuseppe Coppolino ◽  
Nicolino Comi ◽  
Giorgio Fuiano ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Case Series ◽  
Adult Patients ◽  
Single Center ◽  
Single Center Experience ◽  
Steroid Dependent ◽  
The Mean ◽  
Steroid Dependent Nephrotic Syndrome

Abstract Background and Aims Steroid-dependent nephrotic syndrome (SDNS) may require a prolonged multi-drug therapy with risk of drug toxicity and renal failure. Rituximab (RTX) treatment has been found to be helpful in reducing the steroid dosage and the need for immunosuppressants (ISs), but little data are currently available regarding very long-term outcomes in adults. We herein describe a long-term, single-center experience of RTX use in a large series of adults with SDNS. Method We studied 23 adult patients with SDNS (mean age 54.2±17.1 y; 65% male; BMI 28.5±4.7), mostly consequent to membranous (47.8%) or focal glomerulonephritis (30.2 %) who were eligible to start a RTX regimen. Before entering the RTX protocol, proteinuria and eGFR were 7.06±3.87 g/24h and 65.9±28.2 ml/min/1.73 m2, respectively; albumin and CD19/CD20 ratio were 2.9±0.9 g/L and 0.99±0.01 respectively; the mean number of ISs was 2.39±0.89 and the mean annual rate of relapses was 2.2±0.9. Results Patients were followed over a mean follow-up of 64 months (range: 12-144). After RTX (mean dose: 1202.1±372.4 mg) the rate of relapses was virtually nullified (p<0.001). eGFR remained roughly stable (62.1±19.8 ml/min/1.73 m2, p=NS), while proteinuria, albumin, CD19/CD20 and BMI all significantly improved (p ranging from 0.01 to 0.001). The mean number of additional ISs was also reduced (0.44±0.12; p<0.001) and RTX enabled discontinuation of steroids in 13/23 (56.5%) patients. No major adverse events related to therapy were recorded. Conclusion Findings from this large case-series with a remarkable very long follow-up reinforce the role of RTX as an efficient and safe weapon to improve outcomes in adult patients suffering from SDNS.

Long-term ciclosporin treatment in children with steroid-dependent nephrotic syndrome

1993 ◽  
Vol 7 (3) ◽  
pp. 249-252 ◽  
Author(s):  
Ryojiro Tanaka ◽  
Norishige Yoshikawa ◽  
Yoshitaka Kitano ◽  
Hiroshi Ito ◽  
Hajime Nakamura
Keyword(s):  
Nephrotic Syndrome ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Clinical evaluation of chronic nephrotoxicity of long-term cyclosporine A treatment in adult patients with steroid-dependent nephrotic syndrome

Nephrology ◽  
2011 ◽  
Vol 16 (3) ◽  
pp. 319-325 ◽  
Author(s):  
TOMONARI OKADA ◽  
HIROSHI MATSUMOTO ◽  
YUME NAGAOKA ◽  
RYO TOMARU ◽  
HIDEAKI IWASAWA ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Clinical Evaluation ◽  
Cyclosporine A ◽  
Adult Patients ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

The effect of alternate-day low dose prednisolone on bone age in children with steroid dependent nephrotic syndrome

1997 ◽  
Vol 29 (3) ◽  
pp. 357-361 ◽  
Author(s):  
Z. Bircan ◽  
M. Soran ◽  
I. Yildirim ◽  
M. Doĝan ◽  
A. Şahin ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Low Dose ◽  
Bone Age ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Rituximab for very low dose steroid-dependent nephrotic syndrome in children: a randomized controlled study

2020 ◽  
Vol 35 (8) ◽  
pp. 1437-1444
Author(s):  
Pietro Ravani ◽  
Francesca Lugani ◽  
Isabella Pisani ◽  
Monica Bodria ◽  
Giorgio Piaggio ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Low Dose ◽  
Randomized Controlled Study ◽  
Controlled Study ◽  
Randomized Controlled ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

Long-term follow-up after cyclophosphamide therapy in steroid-dependent nephrotic syndrome

2011 ◽  
Vol 26 (6) ◽  
pp. 915-920 ◽  
Author(s):  
Alberto Zagury ◽  
Anne Louise de Oliveira ◽  
Carlos Augusto Pinheiro de Moraes ◽  
Jose Augusto de Araujo Montalvão ◽  
Regina Helena Leite Lemos Novaes ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Cyclophosphamide Therapy ◽  
Steroid Dependent ◽  
Long Term Follow Up ◽  
Steroid Dependent Nephrotic Syndrome

scholarly journals Efficacy and safety of long-term levamisole therapy in maintaining remission in steroid dependent nephrotic syndrome

2017 ◽  
Vol 46 (4) ◽  
pp. 357
Author(s):  
H Dharmawardane ◽  
S Abeyagunawardena ◽  
U I Karunadasa ◽  
A H H M Jayaweera ◽  
A S Abeyagunawardena
Keyword(s):  
Nephrotic Syndrome ◽  
Efficacy And Safety ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome

The effect of alternate-day low-dose prednisolone on bone age in children with steroid-dependent nephrotic syndrome

1996 ◽  
Vol 10 (3) ◽  
pp. 397-398
Author(s):  
Zel�l Bircan ◽  
Mustafa Soran ◽  
Idris Yildirim ◽  
Meral Dogan ◽  
Arif Sahin ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Low Dose ◽  
Bone Age ◽  
Steroid Dependent ◽  
Steroid Dependent Nephrotic Syndrome
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