Transfer of Vitamin E from Plasma Lipoproteins to Tissues and Cells

Vitamin E ◽  
2015 ◽  
pp. 95-102
Author(s):  
William Cohn ◽  
Peter Gross ◽  
Hugo Grun ◽  
Francine Loechleiter ◽  
David P. R. Muller ◽  
...  
Keyword(s):  
Vitamin E ◽  
Plasma Lipoproteins

scholarly journals Vitamin E in fortified cow milk uniquely enriches human plasma lipoproteins

2001 ◽  
Vol 74 (2) ◽  
pp. 211-218 ◽  
Author(s):  
KC Hayes ◽  
Andrzej Pronczuk ◽  
Daniel Perlman
Keyword(s):  
Vitamin E ◽  
Human Plasma ◽  
Plasma Lipoproteins ◽  
Cow Milk

Vitamin E Transfer from Lipid Emulsions to Plasma Lipoproteins: Mediation by Multiple Mechanisms

Lipids ◽  
2008 ◽  
Vol 43 (7) ◽  
pp. 663-671 ◽  
Author(s):  
M. Hacquebard ◽  
M. Vandenbranden ◽  
W. J. Malaisse ◽  
J. M. Ruysschaert ◽  
R. J. Deckelbaum ◽  
...  
Keyword(s):  
Vitamin E ◽  
Plasma Lipoproteins ◽  
Lipid Emulsions

scholarly journals Consuming nutritional doses of olive pomace oil fulfils recommended dietary allowances of alpha-tocopherol. Results from a randomized clinical trial

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Susana Gonzalez-Ramila ◽  
Joaquin Garcia-Cordero ◽  
Beatriz Sarria ◽  
Laura Bravo ◽  
Raquel Mateos
Keyword(s):  
Clinical Trial ◽  
Vitamin E ◽  
Sunflower Oil ◽  
Daily Intake ◽  
Alpha Tocopherol ◽  
Plasma Lipoproteins ◽  
Controlled Clinical Trial ◽  
Olive Pomace ◽  
Olive Pomace Oil ◽  
Wide Range

AbstractVitamin E is a powerful antioxidant that prevents free radical propagation in membranes and plasma lipoproteins. Recommended Daily Allowance (RDA), stablished at 13 and 11 mg/day for adult men and women, respectively, is not fulfilled in most European countries. Thus, strategies to cover the daily recommendations of this vitamin are essential, and one may be to encourage the consumption of foods rich in this micronutrient.Olive-pomace oil (OPO), which is obtained from the solid by-product obtained during olive oil extraction, is nutritionally relevant due to its high content in oleic acid (C18:1), among other monounsaturated fatty acids. In addition, OPO contains a wide range of minor bioactive components that may contribute to its healthy properties. Among these, it is especially relevant the high content of vitamin E in OPO.The objective of the present study was to assess the effect of consuming nutritional relevant doses of olive pomace oil within a normal, non-supplemented diet, in the vitamin E status in adults.We carried out a randomized, cross-over, controlled clinical trial, 14 weeks long in 70 subjects, consisting in two 4-week interventions in which volunteers consumed either OPO or high oleic sunflower oil (HOSO) preceded each by 3-week wash-out steps with sunflower oil. Participants daily consumed 50 mL of either OPO or HOSO, containing 357 and 420 ppm vitamin E, respectively, to meet the nutritional requirements of fat intake. Intake of macronutrients and micronutrients (vitamin E) was analyzed using the DIAL software (Faculty of Pharmacy, Complutense University of Madrid).The results obtained showed that the average consumption of vitamin E increased from 9.61 mg/day (intake of volunteers before starting the study) to 17.76 mg/day and 18.45 mg/day after the intervention with OPO and HOSO, respectively. Acceptance tests to evaluate the level of satisfaction of both oils showed higher preference of OPO compared to HOSO.OPO was well accepted and, thus, constitutes an important dietary source of vitamin E covering the recommended daily intake. It is worth thinking about OPO as part of a healthy diet.

scholarly journals Comparative 2H-labelled α-tocopherol biokinetics in plasma, lipoproteins, erythrocytes, platelets and lymphocytes in normolipidaemic males

2005 ◽  
Vol 94 (1) ◽  
pp. 92-99 ◽  
Author(s):  
Yvonne M. Jeanes ◽  
Wendy L. Hall ◽  
John K. Lodge
Keyword(s):  
Vitamin E ◽  
Individual Variation ◽  
Maximum Concentration ◽  
Area Under The Curve ◽  
Plasma Lipoproteins ◽  
Tocopheryl Acetate ◽  
Blood Components ◽  
Standard Meal ◽  
Biokinetic Parameters ◽  
Initial Peak

The biokinetics of newly absorbed vitamin E in blood components was investigated in normolipidaemic males. Subjects (n 12) ingested encapsulated 150 mg 2H-labelled RRR-α-tocopheryl acetate with a standard meal. Blood was collected at 3, 6, 9, 12, 24 and 48 h post-ingestion. 2H-Labelled and pre-existing unlabelled α-tocopherol (α-T) was determined in plasma, lipoproteins, erythrocytes, platelets and lymphocytes by LC–MS. In all blood components, labelled α-T concentration significantly increased while unlabelled decreased following ingestion (P<0·0001). Significant differences in labelled α-T biokinetic parameters were found between lipoproteins. Time of maximum concentration was significantly lower in chylomicrons, while VLDL had a significantly greater maximum α-T concentration and area under the curve (AUC) (P<0·05). The largest variability occurred in chylomicron α-T transport. Erythrocyte labelled α-T concentrations increased gradually up to 24 h while α-T enrichment of platelets and lymphocytes was slower, plateauing at 48 h. Platelet enrichment with labelled α-T was biphasic, the initial peak coinciding with the labelled α-T peak in chylomicrons. Erythrocyte and HDL AUC were significantly correlated (P<0·005), as was platelet and HDL AUC (P<0·05). There was a lower turnover of pre-existing α-T in platelets and lymphocytes (maximum 25 % labelled α-T) compared to plasma and erythrocytes (maximum 45 % labelled α-T). These data indicate that different processes exist in the uptake and turnover of α-T by blood components and that chylomicron α-T transport is a major determinant of inter-individual variation in vitamin E response. This is important for the understanding of α-T transport and uptake into tissues.

Increased oxidation resistance of atherogenic plasma lipoproteins at high vitamin E levels in non-vitamin E supplemented men

1996 ◽  
Vol 124 (1) ◽  
pp. 83-94 ◽  
Author(s):  
Elina Porkkala-Sarataho ◽  
Kristiina Nyyssönen ◽  
Jukka T. Salonen
Keyword(s):  
Vitamin E ◽  
Oxidation Resistance ◽  
Plasma Lipoproteins ◽  
High Vitamin

scholarly journals The antioxidant paradox: Damage and defence

2006 ◽  
Vol 28 (5) ◽  
pp. 9-12
Author(s):  
David A. Bender
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Vitamin E ◽  
Epidemiological Studies ◽  
Plasma Lipoproteins ◽  
Radical Chain ◽  
Chain Reactions ◽  
Key Factor ◽  
Intervention Trials ◽  
Radical Damage

Over the last three decades, a considerable body of evidence has accumulated to suggest that a key factor in the development of both cancer and coronary heart disease is damage to tissues or plasma lipoproteins caused by free radicals. The majority of radicals that damage tissues are reactive oxygen species, and compounds that can quench potentially damaging radical chain reactions are therefore generally referred to as antioxidants. Epidemiological studies have shown a negative correlation between intakes of antioxidants (especially vitamin E and -carotene) and the incidence of cancer and coronary heart disease, and a positive correlation between markers of radical damage and disease. At the molecular level, there are sound theories to explain how radical damage can lead to cancer and coronary heart disease, and how antioxidants may provide protection. However, the results of intervention trials of vitamin E and -carotene have been, at best, disappointing; indeed, many trials have shown increased death among people taking supposedly protective antioxidant supplements. This is the antioxidant paradox.

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