Metabolic Effects of Low-Protein Low-Phosphorus Diet in Patients with Chronic Renal Failure

2015 ◽  
pp. 157-166 ◽  
Author(s):  
M. Aparicio ◽  
C. Combe ◽  
M. H. Lafage ◽  
V. de Precigout ◽  
J. L. Bouchet ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Metabolic Effects ◽  
Low Protein ◽  
Low Phosphorus

scholarly journals Progression of chronic renal failure on substituting a ketoacid supplement for an amino acid supplement.

1992 ◽  
Vol 2 (7) ◽  
pp. 1178-1185 ◽  
Author(s):  
M Walser ◽  
S Hill ◽  
L Ward
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Amino Acid ◽  
Essential Amino Acid ◽  
Plasma Lipids ◽  
Urinary Cortisol ◽  
Amino Acid Supplement ◽  
Low Protein ◽  
Acid Supplement ◽  
Low Phosphorus

Twelve patients with severe chronic renal failure (average initial GFR, 13 mL/min) were monitored for 4 to 23 months while receiving an essential amino acid supplement and were then switched to a ketoacid supplement for 6 to 40 months, while continuously receiving a very low-protein (0.3 g/kg), low-phosphorus (7 to 9 mg/kg) diet. Urinary urea N excretion indicated that actual dietary protein intake averaged 0.46 g/kg. Progression, estimated as the linear regression slope of radioisotopically determined GFR on time, slowed from -0.46 +/- 0.31 (SD) to -0.24 +/- 0.15 mL/min/month (P = 0.029). Serum urea N, creatinine, phosphate, and uric acid rose significantly as GFR fell; blood pressure, plasma lipids, and urinary urea excretion were unchanged. Urinary 17-hydroxy-corticosteroid excretion decreased 18%, but this change was only marginally significant (P = 0.087). There was no change in plasma or urinary cortisol or urinary aldosterone. Viewed in light of previous evidence that progression seldom slows when treatment remains constant, the results suggest that this ketoacid supplement slows progression by approximately half, compared with an essential amino acid supplement, with no change in diet.

Low protein and low phosphorus diet in patients with chronic renal failure: Influence on glucose tolerance and tissue insulin sensitivity

Metabolism ◽  
1987 ◽  
Vol 36 (11) ◽  
pp. 1080-1085 ◽  
Author(s):  
H. Gin ◽  
M. Aparicio ◽  
L. Potaux ◽  
V. de Precigout ◽  
J.L. Bouchet ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Insulin Sensitivity ◽  
Glucose Tolerance ◽  
Low Protein ◽  
Low Phosphorus

scholarly journals Adaptive Response to a Low-Protein Diet in Predialysis Chronic Renal Failure Patients

2001 ◽  
Vol 12 (6) ◽  
pp. 1249-1254
Author(s):  
JACQUES BERNHARD ◽  
BERNARD BEAUFRÈRE ◽  
MAURICE LAVILLE ◽  
DENIS FOUQUE
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Energy Intake ◽  
Protein Intake ◽  
Protein Diet ◽  
Metabolic Effects ◽  
Low Protein Diet ◽  
Controlled Study ◽  
Food Record ◽  
Low Protein

Abstract. A randomized, controlled study of 12 patients with mild chronic renal failure was designed to assess the metabolic effects of a low-protein diet supplemented (n= 6) or not (n= 6) with ketoanalogs of amino acids. The protein intake was prescribed so that both groups were isonitrogenous. The dietary survey each month included a 3-d food record and a 24-h urine collection for urea measurement. After a 4- to 6-wk equilibrium period (standard occidental diet, 1.11 g of protein and 32 kcal/kg per d), patients reduced their protein intake to reach 0.71 g of protein/kg per d during the third month. Energy intake was kept constant (31 kcal/kg per d) during the 3-mo period. Compliance to the diet was achieved after 2 mo of training. Leucine turnover measurement was performed before and at the end of the 3-mo low-protein period. There was no clinical change, whereas total body flux decreased by 8% (P< 0.05) and leucine oxidation by 18% (P< 0.05). No difference could be attributed to the ketoanalogs themselves. Thus, under sufficient energy intake, a low-protein diet is nutritionally and metabolically safe during chronic renal failure. The nitrogen-sparing effect of a low-protein diet is still present during mild chronic renal insufficiency.

Effects of a low-protein, low-phosphorus diet on metabolic insulin clearance in patients with chronic renal failure

1994 ◽  
Vol 59 (3) ◽  
pp. 663-666 ◽  
Author(s):  
H Gin ◽  
C Combe ◽  
V Rigalleau ◽  
C Delafaye ◽  
M Aparicio ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Insulin Clearance ◽  
Low Protein ◽  
Low Phosphorus

Comparison of a Vegetable-Based (Soya) and an Animal-Based Low-Protein Diet in Predialysis Chronic Renal Failure Patients

Nephron ◽  
1998 ◽  
Vol 79 (2) ◽  
pp. 173-180 ◽  
Author(s):  
N. Soroka ◽  
D.S. Silverberg ◽  
M. Greemland ◽  
Y. Birk ◽  
M. Blum ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Predialysis Chronic Renal Failure

scholarly journals Survival on dialysis among chronic renal failure patients treated with a supplemented low-protein diet before dialysis.

1995 ◽  
Vol 6 (5) ◽  
pp. 1379-1385
Author(s):  
J Coresh ◽  
M Walser ◽  
S Hill
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Mortality Rate ◽  
Serum Creatinine ◽  
Dietary Treatment ◽  
Mortality Rates ◽  
Protein Restriction ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

Concerns have been raised about the possibility of protein restriction resulting in malnutrition and poor subsequent survival on dialysis. However, no studies have examined patients treated with protein restriction to determine their subsequent survival on dialysis. This study prospectively monitored 67 patients with established chronic renal failure (mean initial serum creatinine of 4.3 mg/dL) who were treated with a very low-protein diet (0.3 g/kg per day) supplemented with either essential amino acids or a ketoacid-amino acid mixture and observed closely for clinical complications. Forty-four patients required dialysis. Once dialysis was started, dietary treatment was no longer prescribed. The cumulative mortality rate during the first 2 yr after starting dialysis was 7% (95% confidence interval, 0 to 16%). During this period, only two deaths occurred compared with 11.5 deaths expected on the basis of national mortality rates adjusted for age, sex, race, and cause of renal disease (P = 0.002). However, the protective effect was limited to the first 2 yr on dialysis. Thereafter, mortality rates increased, resulting in a total of 10 deaths during 96.4 person-years of follow-up, which was not significantly lower than the 14.9 deaths expected (P = 0.25). Extrapolation of sequential serum creatinine measurements made before dietary treatment suggests that the improved survival cannot be due to the early initiation of dialysis. Although the lack of an internal control group and data on dialysis lends uncertainty, the large difference in mortality rate between these patients and the nationwide experience indicates that protein restriction and close clinical monitoring predialysis does not worsen and may substantially improve survival during the first 2 yr on dialysis. These findings point out the importance of studying predialysis treatments as a means for lowering mortality on dialysis.

scholarly journals A Low-Nitrogen Low-Phosphorus Vegan Diet for Patients with Chronic Renal Failure

Nephron ◽  
1996 ◽  
Vol 74 (2) ◽  
pp. 390-394 ◽  
Author(s):  
Giuliano Barsotti ◽  
Ester Morelli ◽  
Adamasco Cupisti ◽  
Mario Meola ◽  
Lucia Dani ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Vegan Diet ◽  
Low Phosphorus ◽  
Low Nitrogen
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