Development of Anticipatory Control Mechanisms for Manipulation

A joint center has been established by the University of Pittsburgh and the Excerpta Medica Foundation. The basic objective of the Center is to seek ways in which the health sciences community may achieve increasingly convenient and economical access to scientific findings. The research center will make use of facilities and resources of both participating institutions. Cooperating from the University of Pittsburgh will be the School of Medicine, the Computation and Data Processing Center, and the Knowledge Availability Systems (KAS) Center. The KAS Center is an interdisciplinary organization engaging in research, operations, and teaching in the information sciences.Excerpta Medica Foundation, which is the largest international medical abstracting service in the world, with offices in Amsterdam, New York, London, Milan, Tokyo and Buenos Aires, will draw on its permanent medical staff of 54 specialists in charge of the 35 abstracting journals and other reference works prepared and published by the Foundation, the 700 eminent clinicians and researchers represented on its International Editorial Boards, and the 6,000 physicians who participate in its abstracting programs throughout the world. Excerpta Medica will also make available to the Center its long experience in the field, as well as its extensive resources of medical information accumulated during the Foundation’s twenty years of existence. These consist of over 1,300,000 English-language _abstract of the world’s biomedical literature, indexes to its abstracting journals, and the microfilm library in which complete original texts of all the 3,000 primary biomedical journals, monitored by Excerpta Medica in Amsterdam are stored since 1960.The objectives of the program of the combined Center include: (1) establishing a firm base of user relevance data; (2) developing improved vocabulary control mechanisms; (3) developing means of determining confidence limits of vocabulary control mechanisms in terms of user relevance data; 4. developing and field testing of new or improved media for providing medical literature to users; 5. developing methods for determining the relationship between learning and relevance in medical information storage and retrieval systems’; and (6) exploring automatic methods for retrospective searching of the specialized indexes of Excerpta Medica.The priority projects to be undertaken by the Center are (1) the investigation of the information needs of medical scientists, and (2) the development of a highly detailed Master List of Biomedical Indexing Terms. Excerpta Medica has already been at work on the latter project for several years.

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Control of Thrombin Mediated Cleavage of Protein S

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661630 ◽

1986 ◽

Vol 56 (02) ◽

pp. 151-154 ◽

Cited By ~ 16

Author(s):

Christina A Mitchell ◽

Lena Hau ◽

Hatem H Salem

Keyword(s):

Anticoagulant Activity ◽

Activated Protein C ◽

Surface Protein ◽

Protein S ◽

Intact Protein ◽

Control Mechanisms ◽

Physiological Control ◽

Endothelial Cell Surface ◽

Thrombin Cleavage ◽

Cofactor Activity

SummaryThrombin has been shown to cleave the vitamin K dependent cofactor protein S with subsequent loss of its cofactor activity. This study examines the control mechanisms for thrombin cleavage of protein S.The anticoagulant activity of activated protein C (APC) is enhanced fourteen fold by the addition of protein S. Thrombin cleaved protein S is seven fold less efficient than the native protein, and this loss of activity is due to reduced affinity of cleaved protein S for APC or the lipid surface compared to the intact protein.In the absence of Ca++, protein S is very sensitive to minimal concentrations of thrombin. As little as 1.5 nM thrombin results in complete cleavage of 20 nM protein S in 10 min and loss of cofactor activity. Ca++, in concentrations greater than 0.5 mM, will inhibit this cleavage and in the presence of physiological Ca++ concentrations, no cleavage of protein S could be demonstrated in spite of high concentrations of thrombin (up to 1 μM) and prolonged incubations (up to two hours). The endothelial surface protein thrombomodulin is very efficient in inhibiting the cleavage of protein S by thrombin suggesting that any thrombin formed on the endothelial cell surface is unlikely to cleave protein S, thus allowing the intact protein to act as a cofactor to APC.We conclude that the inhibitory effects of Ca++ and thrombomodulin on thrombin mediated cleavage of protein S imply that this event, by itself, is unlikely to represent a physiological control of the activity of protein S.

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Control Mechanisms for Protecting the Benevolent Partner in the Relationship between Marketing Channel Members

Journal of Marketing Thought ◽

10.15577/jmt.2014.01.01.43 ◽

2014 ◽

Vol 01 (01) ◽

pp. 43-49 ◽

Cited By ~ 1

Author(s):

Sungmin Ryu

Keyword(s):

Marketing Channel ◽

Control Mechanisms ◽

The Relationship

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The Condition for Absolute Stability of an Electroelastic Actuator Control System for Nanomechatronics

Elektrichestvo ◽

10.24160/0013-5380-2020-10-52-58 ◽

2020 ◽

Vol 10 (10) ◽

pp. 52-58

Author(s):

Sergey M. AFONIN ◽

Keyword(s):

Control System ◽

Adaptive Optics ◽

Absolute Stability ◽

Deformation Characteristic ◽

Straight Line Segment ◽

Control Mechanisms ◽

Relative Width ◽

Random Inputs ◽

Deformation Control ◽

Actuator Control

An electroelastic actuator for nanomechatronics is used in nanotechnology, adaptive optics, microsurgery, microelectronics, and biomedicine to actuate or control mechanisms, systems based on the electroelastic effect, and to convert electrical signals into mechanical displacements and forces. In nanomechatronic systems, a piezoactuator is used in scanning microscopy, laser systems, in astronomy for precision alignment, for compensation of temperature, gravitational deformations and atmospheric turbulence, focusing, and stabilizing the image. In this study, a condition for absolute stability of an electroelastic actuator control system for nanomechatronics under deterministic and random inputs is obtained. A number of equilibrium positions in an electroelastic actuator mechatronic control system are found, the totality of which is represented by a straight line segment. The electroelastic actuator’s deformation control system dead band relative width is determined for the actuator’s symmetric and asymmetric hysteresis characteristics. Under deterministic inputs and with fulfilling the condition for the derivative of the nonlinear hysteresis actuator deformation characteristic, the set of equilibrium positions of the electroelastic actuator control system for nanomechatronics is absolutely stable. Under random inputs, the system absolute stability with respect to the mathematical expectations of the electroelastic actuator mechatronic control system equilibrium positions has been determined subject to fulfilling the condition on the derivative of the actuator hysteresis characteristic.

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