Oxygen Free Radicals, Lipid Metabolism, and Whole Blood and Plasma Viscosity in the Prevention and Treatment of Human Cardiovascular Diseases

2015 ◽  
pp. 111-124 ◽  
Author(s):  
Gy. M�zsik ◽  
M. Fiegler ◽  
I. Juricskay ◽  
B. Mezey ◽  
K. T�th
Keyword(s):  
Free Radicals ◽  
Lipid Metabolism ◽  
Cardiovascular Diseases ◽  
Whole Blood ◽  
Oxygen Free Radicals ◽  
Plasma Viscosity ◽  
Prevention And Treatment

scholarly journals Ersonified diagnostic and correction dyslipidemia approach by profiling of apolipoproteins

2020 ◽  
pp. 88-104
Author(s):  
M. A. Kachkovsky ◽  
I. P. Vvedenskaya ◽  
V. Yu. Vvedensky ◽  
A. A. Supilnikov ◽  
J. V. Ponomareva ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Cardiovascular Diseases ◽  
Genetic Polymorphisms ◽  
Clinical Recommendations ◽  
Treatment And Prevention ◽  
Target Values ◽  
Prevention And Treatment ◽  
Protein Components

Many questions remain in the diagnosis, treatment, and prevention of dyslipidemia, despite the available clinical recommendations. Among these issues is the cause of cardiovascular diseases, when achieving and maintaining the target values of lipid metabolism. We need to change the existing paradigm. Apolipoproteins as protein components of lipoproteins can significantly more accurately characterize the dyslipidemic status of a patient, since their structure and composition are unique. A personalized strategy for the prevention and treatment of dyslipidemia is possible based on the apolipoprotein profile. At present, new data on the functions of apolipoproteins, their genetic polymorphisms, and molecular preparations for correcting their content and lipid metabolism have been proposed.

Viscosity and Red Cell Deformity in Arterial Disease

1979 ◽  
Author(s):  
G Cella ◽  
H de Haas ◽  
M Rampling ◽  
V Kakkar
Keyword(s):  
Vascular Disease ◽  
Blood Viscosity ◽  
Whole Blood ◽  
Arterial Disease ◽  
Plasma Viscosity ◽  
Control Group ◽  
Fibrinogen Concentration ◽  
Red Cell ◽  
Whole Blood Viscosity ◽  
Significant Difference

Haemorrheological factors have been shown to be affected in many kings of vascular disease. The present study was undertaken to correlate these factors in normal subjects and patients suffering from peripheral arterial disease. Twenty-two patients were investigated; they had moderate or severe intermittent claudication, extent of disease being confirmed by aorto-arteriography and ankle-systolic pressure studies. Twenty-five controls with no symptoms or signs of arterial disease were selected with comparable age and sex distribution. Whole blood viscosity was measured at shear rates of 230 secs-1 and 23 secs-lat 37°c using a Wells Brookfield cone plate microvisco meter. Plasma viscosity was also measured in an identical manner. Erythrocyte flexibility was measured by centrifuge technique and fibrinogen concentration as well as haematocrit by standard techniques. The fibrinogen concentration appeared to be the only significant parameter; the mean concentration in patients with peripheral vascular disease of 463 ± 73mg/l00ml in the control group ( < 0.05). Although whole blood viscosity was high in patients, when corrected to a common haematocrit, there was no significant difference between patients and controls. The same megative correlation was found for plasma viscosity. The red cell flexibility was found to be increased in patients as compared to the control group, but this effect appeared to be simply proportional to the fibrinogen concentration.

scholarly journals Flavonoids improve drought tolerance of maize seedlings by regulating the homeostasis of reactive oxygen species

2021 ◽  
Author(s):  
Baozhu Li ◽  
Ruonan Fan ◽  
Guiling Sun ◽  
Ting Sun ◽  
Yanting Fan ◽  
...  
Keyword(s):  
Free Radicals ◽  
Drought Stress ◽  
Drought Tolerance ◽  
Infrared Imaging ◽  
Oxygen Free Radicals ◽  
Transcriptome Profiling ◽  
Far Infrared ◽  
Drought Treatment ◽  
Physiological Characterization ◽  
Oxidative Damages

Abstract Background and aims As drought threatens the yield and quality of maize (Zea mays L.), it is important to dissect the molecular basis of maize drought tolerance. Flavonoids, participate in the scavenging of oxygen free radicals and alleviate stress-induced oxidative damages. This study aims to dissect the function of flavonoids in the improvement of maize drought tolerance. Methods Using far-infrared imaging screening, we previously isolated a drought overly insensitivity (doi) mutant from an ethyl methanesulfonate (EMS)-mutagenized maize library and designated it as doi57. In this study, we performed a physiological characterization and transcriptome profiling of doi57 in comparison to corresponding wild-type B73 under drought stress. Results Under drought stress, doi57 seedlings displayed lower leaf-surface temperature (LST), faster water loss, and better performance in growth than B73. Transcriptome analysis reveals that key genes involved in flavonoid biosynthesis are enriched among differentially expressed genes in doi57. In line with these results, more flavonols and less hydrogen peroxide (H2O2) were accumulated in guard cells of doi57 than in those of B73 with the decrease of soil water content (SWC). Moreover, the capacity determined from doi57 seedling extracts to scavenge oxygen free radicals was more effective than that of B73 under the drought treatment. Additionally, doi57 seedlings had higher photosynthetic rates, stomatal conductance, transpiration rates, and water use efficiency than B73 exposed to drought stress, resulting in high biomass and greater root/shoot ratios in doi57 mutant plants. Conclusion Flavonoids may facilitate maize seedling drought tolerance by lowering drought-induced oxidative damage as well regulating stomatal movement.

Ethane production as a measure of lipid peroxidation after renal ischemia

1986 ◽  
Vol 251 (5) ◽  
pp. F839-F843 ◽  
Author(s):  
M. S. Paller ◽  
R. P. Hebbel
Keyword(s):  
Lipid Peroxidation ◽  
Free Radicals ◽  
Superoxide Radical ◽  
Oxygen Free Radicals ◽  
Tissue Injury ◽  
Renal Ischemia ◽  
Radical Scavenger ◽  
Base Line ◽  
Ethane Production

After renal ischemia, oxygen free radicals are formed and produce tissue injury, in large part, through peroxidation of polyunsaturated fatty acids. We used an in vivo method to monitor lipid peroxidation after renal ischemia, the measurement of ethane in expired gas, to determine the time course of lipid peroxidation and the effect of several agents to limit lipid peroxidation after renal ischemia. In anesthetized rats there was no significant increase in ethane production during 60 min of renal ischemia. During the first 10 min of renal reperfusion, there was a prompt increase in ethane production from 2.9 +/- 1.3 to 6.3 +/- 1.9 pmol/min (P less than 0.05). Ethane production was significantly increased during the first 50 min of reperfusion and then rapidly tapered to base-line levels. Preischemic administration of allopurinol to prevent superoxide radical generation or the superoxide radical scavenger superoxide dismutase prevented the increase in ethane production during postischemic reperfusion. These studies confirm that there is increase lipid peroxidation following renal ischemia that can be prevented by agents which limit the formation or accumulation of oxygen free radicals. This in vivo method for measuring lipid peroxidation could also be employed to study the effects of ischemia on lipid peroxidation in other organs, as well as to monitor lipid peroxidation in other forms of injury.

Oxygen-free radicals impair fracture healing in rats

1995 ◽  
Vol 66 (5) ◽  
pp. 473-475 ◽  
Author(s):  
Erol Göktürk ◽  
Akin Turgut ◽  
Cengiz Baygu ◽  
Izge Gunal ◽  
Sinan Seber ◽  
...  
Keyword(s):  
Free Radicals ◽  
Fracture Healing ◽  
Oxygen Free Radicals

Oxygen Free Radicals in Shock

1987 ◽  
Vol 122 (8) ◽  
pp. 961
Author(s):  
BEN EISEMAN
Keyword(s):  
Free Radicals ◽  
Oxygen Free Radicals

Oxygen free-radicals mediate the damaging effect of ultraviolet light on membrane mitochondria

IUBMB Life ◽  
1998 ◽  
Vol 46 (1) ◽  
pp. 207-214 ◽  
Author(s):  
Edmundo Chávez ◽  
Cecilia Zazueta ◽  
Adela Cuéllar ◽  
Horacio Reyes-Vivas ◽  
Noemí García
Keyword(s):  
Free Radicals ◽  
Ultraviolet Light ◽  
Oxygen Free Radicals

Oxygen Free Radicals and Brain Dysfunction

1991 ◽  
Vol 57 (1-2) ◽  
pp. 1-17 ◽  
Author(s):  
James A. Jesberger ◽  
J. Steven Richardson
Keyword(s):  
Free Radicals ◽  
Oxygen Free Radicals ◽  
Brain Dysfunction
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