Regulatory Gut Peptides in Hirschsprung�s Disease and Other Gut Motility Disorders

Author(s):  
Peter J. Milla
2012 ◽  
Vol 153 (16) ◽  
pp. 607-614
Author(s):  
Tibor Wittmann

The extent and severity of motility disorders remains heterogeneous in the different parts of the gut, and in most cases failures in gut motility do not correspond with the severity of the symptoms. If diarrhea or fecal incontinence is the leading symptom, or the blood glucose level varies frequently and considerably despite the treatment efforts, the motility of the stomach and bowels is seriously disturbed. The clinical aspects, detailed pathogenesis, diagnostic approach and treatment modalities of gastrointestinal motility disorders in diabetes mellitus are reviewed to help and improve the everyday medical practice. Orv. Hetil., 2012, 153, 607–614.


2018 ◽  
Vol 30 (7) ◽  
pp. e13393 ◽  
Author(s):  
J. D. Z. Chen ◽  
M. Ni ◽  
J. Yin

2010 ◽  
Vol 48 (11) ◽  
pp. 1240-1246 ◽  
Author(s):  
Anwarul Hassan Gilani ◽  
Aslam Khan ◽  
Arif-ullah Khan ◽  
Samra Bashir ◽  
Najeeb-ur Rehman ◽  
...  

2008 ◽  
Vol 37 (2) ◽  
pp. 397-410 ◽  
Author(s):  
Purna Kashyap ◽  
Gianrico Farrugia

2007 ◽  
Vol 42 (11) ◽  
pp. 1289-1293 ◽  
Author(s):  
Hans Törnblom ◽  
Bethan Lang ◽  
Linda Clover ◽  
Charles H. Knowles ◽  
Angela Vincent ◽  
...  

2019 ◽  
Vol 89 (6) ◽  
pp. 1242-1247.e1 ◽  
Author(s):  
Saowanee Ngamruengphong ◽  
Elizabeth Thompson ◽  
Megan McKnight ◽  
Juliana Yang ◽  
Pankaj J. Pasricha

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Wei Han ◽  
Jing Dong Xu ◽  
Feng Xian Wei ◽  
Yong Dong Zheng ◽  
Jian Zhong Ma ◽  
...  

The peach tree,Prunus persica(L.) Batsch, is widely cultivated in China, and its flowers have been used for centuries in traditional Chinese medicine to treat gut motility disorders. But few studies have explored the pharmacological effect ofPrunus persica(L.) Batsch flowers on gastrointestinal motility. In this study, the activities of different extracts fromPrunus persica(L.) Batsch flowers on the smooth muscle contractions were evaluated using isolated colon model, and the ethyl acetate extract (EAE) showed the strongest effects in vitro. EAE (10−8–10−5 g/mL) caused a concentration-dependent stimulatory effect in rat colonic tissue. Additionally, ketotifen (100 µM), cimetidine (10 µM), and pyrilamine (1 µM) produced a significant inhibition of contractions caused by EAE. Furthermore, immunofluorescence and toluidine blue staining revealed increased numbers of mast cells in the EAE group, and EAE increased histamine release from the colonic tissues. These data indicate that EAE has significant prokinetic activity and acts by a mechanism that mainly involves mast cell degranulation. Our study provides a pharmacological basis for the use of an extract ofPrunus persica(L.) Batsch flowers in the treatment of gut motility disorders.


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