The Role of Noradrenergic Locus Coeruleus Neurons in the Dynamic Control of Posture during the Vestibulospinal Reflexes

2015 ◽  
pp. 91-110
Author(s):  
Ottavio Pompeiano
Keyword(s):  
Locus Coeruleus ◽  
Dynamic Control ◽  
Vestibulospinal Reflexes

Role of Vasopressin in the Cardiovascular Response to Stimulation of the Locus Coeruleus*

Endocrinology ◽  
1986 ◽  
Vol 118 (5) ◽  
pp. 1829-1834 ◽  
Author(s):  
KATHLEEN H. BERECEK ◽  
TERRI N. MITCHUM
Keyword(s):  
Locus Coeruleus ◽  
Cardiovascular Response ◽  
Stimulation Of

Role of nitric oxide in the stress-induced release of serotonin in the locus coeruleus

2001 ◽  
Vol 364 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Catrin Sinner ◽  
Stefan Kaehler ◽  
Nicolas Singewald ◽  
Athineos Philippu
Keyword(s):  
Nitric Oxide ◽  
Locus Coeruleus

scholarly journals Calnexin revealed as an ether-a-go-go chaperone by getting mutant worms up and going

2018 ◽  
Vol 150 (8) ◽  
pp. 1059-1061
Author(s):  
Jonathan T. Pierce
Keyword(s):  
Ion Channels ◽  
Dynamic Control ◽  
Cell Types ◽  
K Channel ◽  
Membrane Domains ◽  
Excitable Cells ◽  
Patch Clamp Recording ◽  
Cell Excitability ◽  
Distinct Membrane

The role of ion channels in cell excitability was first revealed in a series of voltage clamp experiments by Hodgkin and Huxley in the 1950s. However, it was not until the 1970s that patch-clamp recording ushered in a revolution that allowed physiologists to witness how ion channels flicker open and closed at angstrom scale and with microsecond resolution. The unexpectedly tight seal made by the patch pipette in the whole-cell configuration later allowed molecular biologists to suck up the insides of identified cells to unveil their unique molecular contents. By refining these techniques, researchers have scrutinized the surface and contents of excitable cells in detail over the past few decades. However, these powerful approaches do not discern which molecules are responsible for the dynamic control of the genesis, abundance, and subcellular localization of ion channels. In this dark territory, teams of unknown and poorly understood molecules guide specific ion channels through translation, folding, and modification, and then they shuttle them toward and away from distinct membrane domains via different subcellular routes. A central challenge in understanding these processes is the likelihood that these diverse regulatory molecules may be specific to ion channel subtypes, cell types, and circumstance. In work described in this issue, Bai et al. (2018. J. Gen. Physiol. https://doi.org/10.1085/jgp.201812025) begin to shed light on the biogenesis of UNC-103, a K+ channel found in Caenorhabditis elegans.

scholarly journals The specification of noradrenergic locus coeruleus (LC) neurones depends on bone morphogenetic proteins (BMPs)

Development ◽  
2002 ◽  
Vol 129 (4) ◽  
pp. 983-991 ◽  
Author(s):  
Astrid Vogel-Höpker ◽  
Hermann Rohrer
Keyword(s):  
Transcription Factors ◽  
Locus Coeruleus ◽  
Bone Morphogenetic Proteins ◽  
Chick Embryos ◽  
Dorsal Midline ◽  
Neural Crest Development ◽  
Roof Plate ◽  
Rhombic Lip ◽  
The Brain

The role of BMPs in the development of the major noradrenergic centre of the brain, the locus coeruleus (LC), was investigated. LC generation is reflected by initial expression of the transcription factors Phox2a and Phox2b in dorsal rhombomere1 (r1), followed by expression of dopamine-β-hydroxylase and tyrosine hydroxylase. Bmp5 is expressed in the dorsal neuroepithelium in proximity to Phox2-expressing cells. BMP inhibition in stage 10 chick embryos resulted in the lack of LC neurones or in their generation at the dorsal midline, and loss of roof plate and rhombic lip, but it did not affect neural crest development. These results reveal late essential BMP functions in the specification of dorsal neuronal phenotypes in r1, including LC neurones, and in the development of dorsal midline structures.

Cocaine‐induced inhibition of process outgrowth in locus coeruleus neurons: role of gestational exposure period and offspring sex

2004 ◽  
Vol 22 (5-6) ◽  
pp. 297-308 ◽  
Author(s):  
Diane M. Snow ◽  
Heidi M. Carman ◽  
Jeffrey D. Smith ◽  
Rosemarie M. Booze ◽  
Marian A. Welch ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Exposure Period ◽  
Gestational Exposure ◽  
Offspring Sex ◽  
Process Outgrowth

Anticonvulsant activity of the noradrenergic locus coeruleus system: Role of beta mediation

1994 ◽  
Vol 169 (1-2) ◽  
pp. 93-96 ◽  
Author(s):  
G. Ferraro ◽  
P. Sardo ◽  
M. Sabatino ◽  
G. Caravaglios ◽  
V. La Grutta
Keyword(s):  
Locus Coeruleus ◽  
Anticonvulsant Activity
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