Role of nitric oxide in the stress-induced release of serotonin in the locus coeruleus

2001 ◽  
Vol 364 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Catrin Sinner ◽  
Stefan Kaehler ◽  
Nicolas Singewald ◽  
Athineos Philippu
Keyword(s):  
Nitric Oxide ◽  
Locus Coeruleus

Role of nitric oxide in rat locus coeruleus in hypoxia-induced hyperventilation and hypothermia

Neuroreport ◽  
2000 ◽  
Vol 11 (13) ◽  
pp. 2991-2995 ◽  
Author(s):  
Gisele Fabris ◽  
Alexandre A. Steiner ◽  
Janete A. Anselmo-Franci ◽  
Luiz G. S. Branco
Keyword(s):  
Nitric Oxide ◽  
Locus Coeruleus

scholarly journals Role of brain angiotensin AT1 receptor in the carbachol-induced natriuresis and expression of nNOS in the locus coeruleus and proximal convoluted tubule.

2007 ◽  
pp. 383-392
Author(s):  
M Wang ◽  
C Jiang ◽  
C Wang ◽  
Q Yao
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Locus Coeruleus ◽  
Sodium Excretion ◽  
Neuronal Nitric Oxide Synthase ◽  
Urinary Sodium Excretion ◽  
Cholinergic Stimulation ◽  
Proximal Tubular ◽  
Oxide Synthase

Central administration of losartan effectively blocked the increase of blood pressure and drinking response induced by angiotensin II (Ang II) or carbachol. However, the relationship between angiotensin AT(1) receptors and the natriuresis induced by brain cholinergic stimuli is still not clear. The purpose of the study is to reveal the role of brain angiotensin AT(1) receptor in the carbachol-induced natriuresis and expression of neuronal nitric oxide synthase (nNOS) in the locus coeruleus (LC) and proximal convoluted tubule (PCT). Our results indicated that 40 min after intracerebroventricular (ICV) injection of carbachol (0.5 microg), urinary sodium excretion was significantly increased to 0.548+/-0.049 micromol x min(-1) x 100 g(-1). Immunohistochemistry showed that carbachol induced an increase of neuronal nitric oxide synthase immunoreactivity (nNOS-IR) in the LC and renal proximal tubular cells. After pretreatment with losartan (20 microg), carbachol-induced urinary sodium excretion was reduced to 0.249+/-0.067 micromol x min(-1) x 100 g(-1). The same was true for carbachol-induced increase of nNOS-IR in the LC and PCT. The present data suggest that ICV cholinergic stimulation could induce a natriuresis and upregulate the activity of nNOS in the LC and PCT. The blockade of AT(1) receptors might downregulate the effects induced by carbachol in the LC and PCT. Consequently, we provide a new evidence that brain angiotensinergic pathway and NO-dependent neural pathway contribute to the natriuresis following brain cholinergic stimulation and thus play an important role in the regulation of fluid homeostasis. Furthermore, the final effect of nitric oxide on proximal tubular sodium reabsorption participated in the natriuresis induced by brain cholinergic stimulation.

scholarly journals Propyretic role of the locus coeruleus nitric oxide pathway

2010 ◽  
Vol 95 (6) ◽  
pp. 669-677 ◽  
Author(s):  
Renato N. Soriano ◽  
Maria I. Ravanelli ◽  
Marcelo E. Batalhao ◽  
Evelin C. Carnio ◽  
Luiz G. S. Branco
Keyword(s):  
Nitric Oxide ◽  
Locus Coeruleus ◽  
Nitric Oxide Pathway

A critical role of iNOS-derived Nitric Oxide (NO) and progesterone in implantation

1998 ◽  
Vol 5 (1) ◽  
pp. 115A-115A
Author(s):  
K CHWALISZ ◽  
E WINTERHAGER ◽  
T THIENEL ◽  
R GARFIELD
Keyword(s):  
Nitric Oxide ◽  
Critical Role
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